BACE1 - beta-secretase 1 Gene

Homo sapiens

Also known as ASP2; BACE; HSPC104

Gene ID: 23621 | Gene type: protein coding

About BACE1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:117,285,698-117,316,256 (from NCBI)

This gene has 18 transcripts (splice variants), 219 orthologues and 9 paralogues. Ubiquitous expression in pancreas (RPKM 33.5), brain (RPKM 30.2) and 24 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature Protease. This transmembrane Protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta Peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]

BACE1 Products(8)

mRNA	Protein	Name
NM_138971.4	NP_620427.1	beta-secretase 1 isoform C precursor
NM_138973.4	NP_620429.1	beta-secretase 1 isoform D precursor
XM_047426686.1	XP_047282642.1	beta-secretase 1 isoform X1
NM_138972.4	NP_620428.1	beta-secretase 1 isoform B precursor
NM_012104.6	NP_036236.1	beta-secretase 1 isoform A preproprotein
NM_001207049.3	NP_001193978.1	beta-secretase 1 isoform F
NM_001411039.1	NP_001397968.1	beta-secretase 1 isoform G
NM_001207048.3	NP_001193977.1	beta-secretase 1 isoform E

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amyloid-beta binding	IPI IPI: Inferred from physical interaction	16407538	GOA
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	10531052	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	10677483	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	12586838	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	8562317	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10677483	GOA
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	24305806	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid-beta formation	IDA IDA: Inferred from direct assay	24352696	GOA
involved in amyloid-beta metabolic process	IDA IDA: Inferred from direct assay	10677483	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	18353773	GOA
involved in positive regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	29371969	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	10531052	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	10531052	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	10531052	GOA
located in cell surface	IDA IDA: Inferred from direct assay	15886016	GOA
located in early endosome	IDA IDA: Inferred from direct assay	15886016	GOA
located in endosome	IDA IDA: Inferred from direct assay	10531052	GOA
located in late endosome	IDA IDA: Inferred from direct assay	16033761	GOA
located in lysosome	IDA IDA: Inferred from direct assay	16033761	GOA
located in multivesicular body	IDA IDA: Inferred from direct assay	24612608	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12586838	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	15886016	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	11466313	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BACE1 Protein Structure

Asp

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

beta-secretase 1

APP beta-secretase	asp 2
aspartyl protease 2	beta-site APP cleaving enzyme 1
beta-site APP-cleaving enzyme	beta-site amyloid beta A4 precursor protein-cleaving enzyme
memapsin-2	membrane-associated aspartic protease 2
transmembrane aspartic proteinase Asp2

Recombinant BACE1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72840	BACE1 Protein, Human (HEK293)	P56817-1/NP_036236.1 (T22-T457)	≥95%
HY-P72842	BACE1 Protein, Human (HEK293, His)	NP_036236.1 (T22-T457)	≥95%
HY-P77569	BACE1 Protein, Human (HEK293, Fc)	P56817-1 (T22-T457)	≥95%

Related Diseases

Diseases

Alias

Down Syndrome

Trisomy 21	Complete Trisomy 21 Syndrome
Down'S Syndrome	Trisomy 21 Syndrome
Down'S Syndrome - Trisomy 21	Downs Syndrome
G Trisomy	47,Xx,+21
47,Xy,+21	Trisomy G
Down Syndrome, Susceptibility To	Chromosome 21 Trisomy
Trisomy 21 Nos	Abnormal Autosomes 21

Inclusion Body Myositis

Ibm	Sporadic Inclusion Body Myositis
Myositis, Inclusion Body	Inflammatory Myopathy
Inflammatory Myopathies	Sibm
Myositis Inclusion Body	Nonaka Myopathy
Inclusion Body Myopathy, Autosomal Recessive	Inclusion Body Myopathy, Autosomal Dominant
Myositis	Inclusion Body Myopathy, Sporadic

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Pick Disease Of Brain

Pick Disease	Pick Disease Of The Brain
Lobar Atrophy Of Brain	Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions
Pick'S Disease	Behavioral Variant Of Frontotemporal Dementia
Dementia In Pick'S Disease	Lobar Atrophy Of The Brain
Bvftd	Bv-Ftd
PIDB	Picks Disease

Neurosyphilis

Syphilis Of Central Nervous System	Late Syphilis Of Central Nervous System Nos
Late Syphilis Of The Central Nervous System	Gumma Of Central Nervous System
Neurosyphilis Gumma	Neurosyphilitic Gumma
Syphilis Of Central Nervous System Nos	Syphilitic Gumma Of Central Nervous System
Tertiary Central Nervous System Syphilis

Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease	CJD
Bovine Spongiform Encephalopathy	Vcjd
Inherited Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Familial
Creutzfeldt Jakob Disease	Creutzfeldt-Jacob Disease
Creutzfeldt Jacob Disease	Sporadic Creutzfeldt-Jakob Disease
Encephalopathy, Bovine Spongiform	Creutzfeldt-Jakob Disease, Variant, Resistance To
Creutzfeldt-Jakob Disease, Variant	Creutzfeldt Jacob Syndrome
Jakob-Creutzfeldt Disease	Subacute Spongiform Encephalopathy
Transmissible Virus Dementia	New Variant Of Cjd
Nv-Cjd	Variant Cjd
Variant Creutzfeldt-Jacob Disease	Sporadic Cjd
Inherited Cjd	Acquired Creutzfeldt-Jakob Disease
Variant Mcj	Encephalopathy Bovine Spongiform
Familial Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Syndrome
New Variant Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Sporadic
Acquired Cjd	Scjd - [Sporadic Creutzfeldt-Jakob Disease]
Idiopathic Creutzfeldt-Jakob Disease	Creutzfeld-Jakob Disease Nos
Vcjd - [Variant Creutzfeldt-Jakob Disease]

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Disease Of Mental Health

Mental Health

Mental Disorders

Polyradiculoneuropathy

Alzheimer Disease 4

AD4	Alzheimer Disease-4
Alzheimer'S Disease 4	Alzheimer Disease, Familial, 4
Alzheimer Disease, Familial4	Alzheimer'S Disease 4, Early Onset
Alzheimer Disease, Type 4

Subjective Cognitive Decline

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Cerebral Amyloid Angiopathy, App-Related

Hchwad	Amyloidosis, Cerebroarterial, App-Related
Amyloidosis, Hereditary, With Cerebral Hemorrhage, Dutch Variant	Cerebral Amyloid Angiopathy, App-Related, Dutch Variant
Cerebral Amyloid Angiopathy, App-Related, Iowa Variant	Cerebral Amyloid Angiopathy, App-Related, Italian Variant
Cerebral Amyloid Angiopathy, App-Related, Flemish Variant	Cerebral Amyloid Angiopathy, App-Related, Arctic Variant
Cerebral Amyloid Angiopathy, Dutch, Italian, Iowa, Flemish, Arctic Variants	App-Related Cerebral Amyloid Angiopathy
Abetaa21g Amyloidosis	Abeta Amyloidosis, Italian Type
Abeta Amyloidosis, Arctic Type	Abeta Amyloidosis, Iowa Type
Abeta Amyloidosis, Dutch Type	Hchwa-D
Abeta Amyloidosis, Flemish Type	Abetaa21g-Related Amyloidosis
Hchwa, Flemish Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Flemish Type
Abetae22k Amyloidosis	Hchwa, Italian Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Italian Type	Abetae22g Amyloidosis
Hchwa, Arctic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Arctic Type
Abetad23n Amyloidosis	Hchwa, Iowa Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Iowa Type	Abetal34v Amyloidosis
Abeta Amyloidosis, Piedmont Type	Abetal34v-Related Amyloidosis
Hchwa, Piedmont Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Piedmont Type
Abetae22q Amyloidosis	Hchwa, Dutch Type
Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type	CAA-APP
Amyloidosis Cerebroarterial App-Related	Amyloidosis Hereditary With Cerebral Hemorrhage Dutch Variant
Cerebral Amyloid Angiopathy App-Related Arctic Variant	Cerebral Amyloid Angiopathy App-Related Dutch Variant
Cerebral Amyloid Angiopathy App-Related Flemish Variant	Cerebral Amyloid Angiopathy App-Related Iowa Variant
Cerebral Amyloid Angiopathy App-Related Italian Variant	Familial Occipital Calcifications With Hemorrhagic Strokes Leukoencephalopathy Arterial Dysplasia Dementia
Fochs-Ladd	Hereditary Cerebral Amyloid Angiopathy Dutch Type
Hereditary Cerebral Hemorrhage With Amyloidosis Dutch Type	Hereditary Cerebral Hemorrhage With Amyloidosis Italian Type
Cerebral Hemorrhage With Amyloidosis, Hereditary, Dutch Type

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Toxic Encephalopathy

Neurotoxicity	Neurotoxicity Syndromes
Neurotoxicity Syndrome	Encephalopathy, Toxic

Mild Cognitive Impairment

Myositis

Idiopathic Inflammatory Myopathy	Idiopathic Inflammatory Myositis
Iim	Imm
Idiopathic Inflammatory Myopathies	Myopathy, Familial Idiopathic Inflammatory
Inflammatory Disorder Of Muscle	Idiopathic Inflammatory Myopathy, Familial
Inflammatory Myopathy, Idiopathic	Myopathies Idiopathic Inflammatory
Familial Idiopathic Inflammatory Myopathy

Chromosomal Duplication Syndrome

Necatoriasis

Miner'S Anaemia	Negro Cachexia
Dochmiasis	Ground Itch Disease
Brickmaker'S Chlorosis	Coolie Itch Anaemia
Cachexia Aquosa	Dew Itch Anaemia
Brickmaker'S Anaemia	Tunnel Worker'S Anaemia
Egyptian Anaemia	Tunnel Worker'S Disease
Miner'S Cachexia	Greisinger Disease
Tropical Chlorosis	Egyptian Chlorosis
Tunnel Anaemia	Dochmiosis
Necatorosis	African Cachexia
Water Itch Anaemia	Infection Due To Necator Americanus
St Gotthard Disease	Gotthard Tunnel Disease

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

Dementia

Dementias	Presenile Dementia
Alzheimer Type Dementia	Alzheimer Sclerosis
Alzheimer Disease Dementia	Alzheimer Dementia
Primary Degenerative Alzheimer Type Dementia	End Stage Alzheimer'S Dementia
Alzheimer'S Type Atypical Dementia	Alzheimer Type Presenile Dementia
Early Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 2
Dementia In Alzheimer Disease With Early Onset	Early Onset Alzheimer Type Dementia, Uncomplicated
Primary Degenerative Alzheimer Type Dementia, Early Onset	Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated
Alzheimer Disease Dementia With Early Onset	Presenile Sclerosis
Presenile Brain Sclerosis	Presenile Alzheimer Brain Sclerosis
Late Onset Alzheimer Dementia	Dementia In Alzheimer Disease Type 1
Dementia In Alzheimer Disease With Late Onset	Primary Degenerative Alzheimer Type Dementia, Late Onset
Sdat - [Senile Dementia, Alzheimer Type]	Alzheimer Disease Dementia With Late Onset
Late Onset Alzheimer Brain Sclerosis	Senile Alzheimer Brain Disease
Senile Alzheimer Brain Sclerosis	Senile Primary Degenerative Alzheimer Type Dementia
Senile Dementia Of The Alzheimer Type	Arteriosclerotic Dementia
Strategic-Infarct Dementia	Post Stroke Dementia
Vascular Cognitive Impairment	Vascular Dementia
Dementia Of The Lewy Body Type	Dementia With Lewy Bodies
Sdlt - [Senile Dementia Of The Lewy Body Type]	Senile Dementia Of The Lewy Body Type
Alcohol-Related Dementia	Alcoholic Dementia Nos
Alcohol-Induced Dementia	Alcoholic Brain Syndrome
Chronic Alcoholic Brain Syndrome	Alcohol Dementia
Late Onset Alcoholic Psychosis	Residual And Late-Onset Alcohol-Induced Psychotic Disorder
Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder	Late-Onset Psychoactive Substance-Induced Psychotic Disorder
Inhalant Dementia	Volatile Solvents Dementia
Dementia In Paralysis Agitans	Pdd - [Parkinson Disease Dementia]
Dementia Syndrome Of Parkinson Disease	Dementia In Parkinson Disease
Parkinson Related Dementia	Dementia In Huntington Chorea
Hiv - [Human Immunodeficiency Virus] Dementia	Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex
Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex	Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex
Aids Related Dementia	Dementia Due To Niacin Deficiency

Vascular Dementia

Dementia, Vascular	Multi Infarct Dementia
Multifocal Dementia	Dementia Vascular
Vascular Dementia, Susceptibility To	Dementia, Multi-Infarct
Multi-Infarct Dementia

Chromosomal Disease

Chromosomal Disorders

Congenital Chromosomal Disease

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Alzheimer Disease 10

Ad10	Alzheimer Disease-10
Alzheimer'S Disease 10	Alzheimer Disease, Familial, 10
Alzheimer Disease Familial 10	Alzheimer'S Disease 10, Early Onset

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy	Hereditary Cerebral Hemorrhage With Amyloidosis
Hchwa	Cerebral Amyloid Angiopathy, Familial
Hereditary Cystatin C Amyloid Angiopathy	Amyloidosis, Cerebroarterial, Icelandic Type
Amyloidosis Vi	Cerebral Hemorrhage, Hereditary, With Amyloidosis
Cst3-Related Cerebral Amyloid Angiopathy	Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant
Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant	Caa, Familial
Cerebral Amyloid Angiopathy, Genetic	Acys Amyloidosis
Cst3-Related Amyloidosis	Cystatin Amyloidosis
Hchwa, Icelandic Type	Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type
Amyloidosis 6	AMYL6
Acys	Caa
Cerebral Amyloid Angiopathy Cst3-Related	Cerebroarterial Amyloidosis Icelandic Type
Cystatin C Amyloidosis	Hccaa
Hchwai	Hchwa-I
Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type	Cerebral Amyloid Angiopathy Familial
Angiopathy, Amyloid, Cerebral, Cst3-Related	Hereditary Cerebral Amyloid Angiopathy, Icelandic Type
Familial Cerebral Amyloid Angiopathy	Cerebral Amyloid Angiopathy, Hereditary

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Alzheimer Disease 3

AD3	Alzheimer Disease, Type 3
Alzheimer Disease, Type 3, With Spastic Paraparesis And Unusual Plaques	Alzheimer Disease, Type 3, With Spastic Paraparesis And Apraxia
Alzheimer'S Disease 3	Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Apraxia
Alzheimer Disease 3, Early-Onset	Alzheimer Disease, Familial, 3
Alzheimer Disease, Protection Against, Due To Apoe3-Christchurch	Alzheimer Disease 3, Early Onset
Alzheimer Disease Familial 3	Early-Onset Familial Alzheimer Disease 3
Familial Alzheimer Disease 3	Familial Alzheimer Disease 3 With Spastic Paraparesis And Apraxia
Familial Alzheimer Disease 3 With Spastic Paraparesis And Unusual Plaques	Alzheimer Disease, Familial, 3, With Spastic Paraparesis And Unusual Plaques
Alzheimer Disease, Familial, Type 3

Amnestic Disorder

Amnesia	Amnestic Syndrome
Korsakoff'S Psychosis Or Syndrome	Amnesic Syndrome
Amnestic Disorder In Conditions Classified Elsewhere	Korsakoff Psychosis Or Syndrome, Nonalcoholic
Nonalcoholic Organic Amnesic Syndrome	Organic Amnesic Syndrome

Cerebrovascular Disease

Cerebrovascular Accident	Cerebrovascular Disorder
Cerebrovascular Disorders	Cva
Stroke

Supranuclear Palsy, Progressive, 1

Progressive Supranuclear Palsy	Steele-Richardson-Olszewski Syndrome
Supranuclear Palsy, Progressive	Psp
Progressive Supranuclear Ophthalmoplegia	PSNP1
Familial Progressive Supranuclear Palsy	Richardson'S Syndrome
Psp Syndrome	Progressive Supranuclear Palsy 1
Supranuclear Palsy Progressive	Ophthalmoplegia, Supranuclear, Progressive
Steele-Richardson-Olszewksi Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16759	Verubecestat	Inhibitor	99.56%	Phase 3
HY-100740	Lanabecestat	Inhibitor	99.67%	Phase 3
HY-13240	LY2886721	Inhibitor	99.74%	Phase 2
HY-114245	Se-Methylselenocysteine	Inhibitor	≥98.0%	Phase 1
HY-10472	LY2811376	Inhibitor	99.89%	Phase 1
HY-109052	Atabecestat	Inhibitor	99.77%	Phase 1
HY-13438	AZD3839 free base	Inhibitor	99.91%	Phase 1
HY-100182	BACE1-IN-1	Inhibitor	99.02%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0226A	Epiberberine chloride	Inhibitor	99.02%	Unkown
HY-15908	BCA	Inhibitor	99.76%	Unkown
HY-136742	BACE2-IN-1	Inhibitor	99.4%	Unkown
HY-N1255	Scoulerine	Inhibitor	99.27%	Unkown
HY-100740C	(1α,1'S,4β)-Lanabecestat	Inhibitor	96.01%	Unkown
HY-111383	LX2343	Inhibitor	99.80%	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.15%	Unkown
HY-N0226	Epiberberine	Inhibitor	98.46%	Unkown
HY-128594	BACE1-IN-4	Inhibitor	/	Unkown
HY-112444	BACE1-IN-2	Inhibitor	/	Unkown
HY-128774	AM-6494	Inhibitor	/	Unkown
HY-130244	BACE1-IN-5	Inhibitor	/	Unkown
HY-12938	AMG-8718	Inhibitor	/	Unkown
HY-N2215	Aloeresin D	Inhibitor	99.69%	Unkown
HY-P2713	OM99-2	Inhibitor	/	Unkown
HY-149211	AChE/BChE-IN-12	Inhibitor	/	Unkown
HY-139720	β-Secretase Inhibitor III	Inhibitor	/	Unkown
HY-P3426	BACE1-IN-10	Inhibitor	/	Unkown
HY-151260	AChE/BACE1/GSK3β-IN-1	Inhibitor	/	Unkown
HY-161359	BACE1-IN-14	Inhibitor	/	Unkown
HY-122080	Memoquin	Inhibitor	/	Unkown
HY-144741	BACE1-IN-9	Inhibitor	/	Unkown
HY-151348	BACE1-IN-11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BACE1	RGD	RGD:2191
Felis catus	BACE1	VGNC	VGNC:69027
Macaca mulatta	BACE1	VGNC	VGNC:70215
Mus musculus	BACE1	MGD	MGI:1346542
Bos taurus	BACE1	VGNC	VGNC:26400
Canis familiaris	BACE1	VGNC	VGNC:38358
Others	BACE1	NCBI