BRD1 - bromodomain containing 1 Gene

Homo sapiens

Also known as BRL; BRPF1; BRPF2

Gene ID: 23774 | Gene type: protein coding

About BRD1

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:49,773,278-49,827,873 (from NCBI)

This gene has 8 transcripts (splice variants), 277 orthologues and 8 paralogues. Broad expression in testis (RPKM 11.6), bone marrow (RPKM 4.4) and 25 other tissues.

Summary

This gene encodes a bromodomain-containing protein that localizes to the nucleus and can interact with DNA and histone tails. The encoded protein is a component of the MOZ/MORF acetyltransferase complex and can stimulate acetylation of histones H3 and H4, thereby potentially playing a role in gene activation. Variation in this gene is associated with schizophrenia and bipolar disorder in some study populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

BRD1 Products(10)

mRNA	Protein	Name
NM_001304808.3	NP_001291737.1	bromodomain-containing protein 1 isoform 1
NM_001304809.1	NP_001291738.1	bromodomain-containing protein 1 isoform 2
NM_001349940.2	NP_001336869.1	bromodomain-containing protein 1 isoform 3
NM_001349941.2	NP_001336870.1	bromodomain-containing protein 1 isoform 4
NM_001349942.2	NP_001336871.1	bromodomain-containing protein 1 isoform 5
NM_001394548.1	NP_001381477.1	bromodomain-containing protein 1 isoform 6
NM_001394549.1	NP_001381478.1	bromodomain-containing protein 1 isoform 7
NM_001394550.1	NP_001381479.1	bromodomain-containing protein 1 isoform 8
NM_001394551.1	NP_001381480.1	bromodomain-containing protein 1 isoform 2
NM_001394552.1	NP_001381481.1	bromodomain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to histone H3K14 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K12 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K5 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
contributes to histone H4K8 acetyltransferase activity	IDA IDA: Inferred from direct assay	16387653	GOA
enables histone binding	IDA IDA: Inferred from direct assay	21880731	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	27142060	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of MOZ/MORF histone acetyltransferase complex	IDA IDA: Inferred from direct assay	16387653	GOA
part of histone H3-K14 acetyltransferase complex	IDA IDA: Inferred from direct assay	21753189	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10602503	GOA
located in nucleus	IMP IMP: Inferred from mutant phenotype	21753189	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD1 Protein Structure

EPL1

PHD_2

zf-HC5HC2H_2

Bromodomain

PWWP

0
200
400
600
800
1000
1058 a.a.

Protein Preferred Names

Protein Names

bromodomain-containing protein 1

BR140-like protein

BRD1 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BRD1	O95696	TFIP11	Homo sapiens	Q9UBB9	Validated Y2H	32296183
Intra	BRD1	O95696	TFIP11	Homo sapiens	Q9UBB9	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	TFIP11	Homo sapiens	Q9UBB9	Y2H Array	32296183
Intra	BRD1	O95696	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	BRD1	O95696	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	BRD1	O95696	CASP8	Homo sapiens	Q6NVI2	Validated Y2H	32296183
Intra	BRD1	O95696	CASP8	Homo sapiens	Q6NVI2	Y2H Array	32296183
Intra	BRD1	O95696	CASP8	Homo sapiens	Q6NVI2	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	32296183
Intra	BRD1	O95696	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	32296183
Intra	BRD1	O95696	HMBOX1	Homo sapiens	Q6NT76	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	RUBCN	Homo sapiens	Q92622	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	RUBCN	Homo sapiens	Q92622	Validated Y2H	32296183
Intra	BRD1	O95696	RUBCN	Homo sapiens	Q92622	Y2H Array	32296183
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Validated Y2H	32296183
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Anti Tag CoIP	33961781
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	BRD1	O95696	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	BRD1	O95696	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	BRD1	O95696	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
Intra	BRD1	O95696	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	BRD1	O95696	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	BRD1	O95696	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	BRD1	O95696	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	BRD1	O95696	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	BRD1	O95696	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Herpes Zoster Oticus

Nervus Intermedius Neuralgia	Ramsay Hunt Syndrome Type 2
Geniculate Herpes Zoster	Geniculate Neuralgia
Herpes Zoster Auricularis	Herpetic Geniculate Ganglionitis
Ramsay Hunt Syndrome Type Ii	Ramsey Hunt Syndrome
Facial Nerve Palsy Due To Vzv	Facial Nerve Palsy Due To Herpes Zoster Infection
Facial Nerve Paralysis Due To Vzv	Hunt Syndrome
Hunt'S Syndrome	Ramsay Hunt Syndrome
Myoclonus And Ataxia

Nodular Prostate

Spinocerebellar Ataxia, X-Linked 5

SCAX5	X-Linked Spinocerebellar Ataxia 5
X-Linked Non Progressive Cerebellar Ataxia

Ohdo Syndrome, Sbbys Variant

Say-Barber-Biesecker-Young-Simpson Syndrome	SBBYSS
Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Sbbys Type
Yss	Sbbys Variant Of Ohdo Syndrome
Blepharophimosis - Intellectual Disability Syndrome, Sbbys Type	Young Simpson Syndrome
Sbbyss Syndrome	Ohdo Syndrome, Say-Barber-Biesecker-Young-Simpson Variant
Blepharophimosis And Mental Retardation Syndrome, Say-Barber/Biesecker/Young-Simpson Type	Blepharophimosis-Intellectual Deficit Syndrome, Say-Barber/Biesecker/Young-Simpson Type
Bmrs Sbbys	Ohdo Syndrome, Say-Barber-Biesecker Variant
Say-Barber-Biesecker-Young-Simpson Variant Of Ohdo Syndrome	Hypothyroidism-Dysmorphism-Postaxial Polydactyly-Intellectual Disability Syndrome
Say-Barber-Biesecker Variant Of Ohdo Syndrome

Adult Brain Stem Glioma

Adult Brainstem Neuroglial Tumor

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect Inhibitor Pre-designed Sets	Purity	Rare Diseases Unkown
HY-19537	NI-57	Inhibitor	99.96%	Unkown
HY-18665	GSK-5959	Inhibitor	98.74%	Unkown
HY-13959	MS436	Inhibitor	99.94%	Unkown
HY-111875	SNIPER(BRD)-1	Inhibitor	99.43%	Unkown
HY-RS01596	BRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-100670	Olinone	Inhibitor	/	Unkown
HY-122626	BRPF1B/TRIM24-IN-1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	BRD1	VGNC	VGNC:26556
Canis familiaris	BRD1	VGNC	VGNC:38518
Macaca mulatta	BRD1	VGNC	VGNC:70280
Mus musculus	BRD1	MGD	MGI:1924161
Rattus norvegicus	BRD1	RGD	RGD:1311855

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