Bace1 - beta-site APP cleaving enzyme 1 Gene

Mus musculus

Also known as ASP2; Bace

Gene ID: 23821 | Gene type: protein coding

About Bace1

Chromosome 9: 45,749,878-45,775,697 forward strand.GRCm39:CM001002.3

This gene has 6 transcripts (splice variants), 219 orthologues, 8 paralogues and is associated with 36 phenotypes. Ubiquitous expression in cerebellum adult (RPKM 19.1), ovary adult (RPKM 19.) and 28 other tissues.

Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta Peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]

Bace1 Products(5)

mRNA	Protein	Name
NM_001410456.1	NP_001397385.1	beta-secretase 1 isoform 4
NM_001410455.1	NP_001397384.1	beta-secretase 1 isoform 3 precursor
NM_001410457.1	NP_001397386.1	beta-secretase 1 isoform 5
NM_001145947.3	NP_001139419.1	beta-secretase 1 isoform 2 precursor
NM_011792.7	NP_035922.4	beta-secretase 1 isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aspartic-type endopeptidase activity	IDA IDA: Inferred from direct assay	25592972	MGI
enables aspartic-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	29325091	MGI
enables endopeptidase activity	IDA IDA: Inferred from direct assay	15123597	MGI
enables endopeptidase activity	IMP IMP: Inferred from mutant phenotype	17099708	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15606899	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in amyloid precursor protein catabolic process	IGI IGI: Inferred from genetic interaction	20704561	MGI
acts upstream of or within amyloid-beta metabolic process	IDA IDA: Inferred from direct assay	25592972	MGI
involved in membrane protein ectodomain proteolysis	IMP IMP: Inferred from mutant phenotype	29325091	MGI
involved in modulation of chemical synaptic transmission	IGI IGI: Inferred from genetic interaction	20943921	MGI
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	18753368	MGI
involved in presynaptic modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	18753368	MGI
acts upstream of or within proteolysis	IDA IDA: Inferred from direct assay	15123597	MGI
involved in signaling receptor ligand precursor processing	IMP IMP: Inferred from mutant phenotype	17099708	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	11740561	MGI
located in cell surface	IDA IDA: Inferred from direct assay	26467158	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	11740561	MGI
located in early endosome	IDA IDA: Inferred from direct assay	25592972	MGI
located in endosome	IDA IDA: Inferred from direct assay	19074428	MGI
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	18753368	MGI
is active in hippocampal mossy fiber to CA3 synapse	IMP IMP: Inferred from mutant phenotype	18753368	MGI
located in membrane	IDA IDA: Inferred from direct assay	15886206	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	29325091	MGI
is active in plasma membrane	IMP IMP: Inferred from mutant phenotype	17099708	MGI
is active in presynapse	IDA IDA: Inferred from direct assay	23820808	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	23931995	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	19074428	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Bace1 Protein Structure

beta_secretase_like

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

beta-secretase 1

APP beta-secretase	asp 2
aspartyl protease 2	beta-site amyloid precursor protein cleaving enzyme 1
memapsin-2	membrane-associated aspartic protease 2

Recombinant Bace1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72843	BACE1 Protein, Mouse (HEK293, His)	NP_035922.4 (T22-T457)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16759	Verubecestat	Inhibitor	99.56%	Phase 3
HY-100740	Lanabecestat	Inhibitor	99.67%	Phase 3
HY-13240	LY2886721	Inhibitor	99.74%	Phase 2
HY-114245	Se-Methylselenocysteine	Inhibitor	≥98.0%	Phase 1
HY-10472	LY2811376	Inhibitor	99.89%	Phase 1
HY-109052	Atabecestat	Inhibitor	99.77%	Phase 1
HY-100182	BACE1-IN-1	Inhibitor	99.02%	Phase 1
HY-13438	AZD3839 free base	Inhibitor	99.91%	Phase 1

Pre-clinical Phase

Bioactive Molecules (24)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0226A	Epiberberine chloride	Inhibitor	99.02%	Unkown
HY-15908	BCA	Inhibitor	99.76%	Unkown
HY-136742	BACE2-IN-1	Inhibitor	99.4%	Unkown
HY-N1255	Scoulerine	Inhibitor	99.27%	Unkown
HY-111383	LX2343	Inhibitor	99.80%	Unkown
HY-100740C	(1α,1'S,4β)-Lanabecestat	Inhibitor	96.01%	Unkown
HY-N2284	Sophoflavescenol	Inhibitor	98.15%	Unkown
HY-N0226	Epiberberine	Inhibitor	98.46%	Unkown
HY-130244	BACE1-IN-5	Inhibitor	/	Unkown
HY-128594	BACE1-IN-4	Inhibitor	/	Unkown
HY-112444	BACE1-IN-2	Inhibitor	/	Unkown
HY-128774	AM-6494	Inhibitor	/	Unkown
HY-12938	AMG-8718	Inhibitor	/	Unkown
HY-122080	Memoquin	Inhibitor	/	Unkown
HY-144741	BACE1-IN-9	Inhibitor	/	Unkown
HY-149211	AChE/BChE-IN-12	Inhibitor	/	Unkown
HY-151348	BACE1-IN-11	Inhibitor	/	Unkown
HY-P3426	BACE1-IN-10	Inhibitor	/	Unkown
HY-151260	AChE/BACE1/GSK3β-IN-1	Inhibitor	/	Unkown
HY-N2215	Aloeresin D	Inhibitor	99.69%	Unkown
HY-P2713	OM99-2	Inhibitor	/	Unkown
HY-139720	β-Secretase Inhibitor III	Inhibitor	/	Unkown
HY-161359	BACE1-IN-14	Inhibitor	/	Unkown
HY-164958	TB-11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bace1	NCBI	NCBI:23621

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