ALDH1A1 - aldehyde dehydrogenase 1 family, member A1 Gene

Rattus norvegicus

Also known as Ahd2; Aldh1; Aldh2

Gene ID: 24188 | Gene type: protein coding

About ALDH1A1

Primary_assembly 1: 218,042,127-218,152,961 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 200 orthologues, 20 paralogues and is associated with 53 phenotypes. Biased expression in Kidney (RPKM 2289.1), Testes (RPKM 1535.4) and 6 other tissues.

Summary

Enables benzaldehyde dehydrogenase (NAD+) activity; identical protein binding activity; and retinal dehydrogenase activity. Involved in several processes, including estrous cycle; maintenance of lens transparency; and retinoic acid metabolic process. Located in cytoplasm and nucleus. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

ALDH1A1 Products(1)

mRNA	Protein	Name
NM_022407.3	NP_071852.2	aldehyde dehydrogenase 1A1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	10998257	RGD
enables aldehyde dehydrogenase (NAD+) activity	IMP IMP: Inferred from mutant phenotype	15623782	RGD
enables benzaldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	10998257	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10998257	RGD
enables retinal dehydrogenase activity	IDA IDA: Inferred from direct assay	7832787	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in 9-cis-retinoic acid metabolic process	IDA IDA: Inferred from direct assay	17167544	RGD
involved in cellular detoxification of aldehyde	IMP IMP: Inferred from mutant phenotype	15623782	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	18202528	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	15567713	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	14729401	RGD
involved in maintenance of lens transparency	IMP IMP: Inferred from mutant phenotype	15623782	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	15964596	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18202528	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	17673211	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18807137	RGD
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	15623782	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	11169459	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10323328	RGD
involved in retinoic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	21138835	RGD
involved in retinoid metabolic process	IDA IDA: Inferred from direct assay	7832787	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH1A1 Protein Structure

ALDH_F1AB_F2_RALDH1

0
100
200
300
400
520 a.a.

Protein Preferred Names

Protein Names

aldehyde dehydrogenase 1A1

retinal dehydrogenase 1

3-deoxyglucosone dehydrogenase	ALDH-E1
ALHDII	RALDH 1
aldehyde dehydrogenase 1, subfamily A1	aldehyde dehydrogenase 2
aldehyde dehydrogenase family 1 member A1	aldehyde dehydrogenase family 1, subfamily A1
aldehyde dehydrogenase, cytosolic	ralDH1

Related Agents

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138097	α-NETA		≥98.0%	Unkown
HY-18768	NCT-501	Inhibitor	99.84%	Unkown
HY-148466	IGUANA-1	Inhibitor	98.88%	Unkown
HY-112278	NCT-506	Inhibitor	99.95%	Unkown
HY-123621	GNE-375	Inhibitor	99.81%	Unkown
HY-135841	CM010	Inhibitor	98.07%	Unkown
HY-112277	NCT-505	Inhibitor	99.37%	Unkown
HY-146683	KS106		99.31%	Unkown
HY-110294	CM037	Inhibitor	99.06%	Unkown
HY-146682	KS100		99.61%	Unkown
HY-122912	ALDH1A inhibitor 673A		99.15%	Unkown
HY-126003	ALDH1A1-IN-2	Inhibitor	99.31%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.30%	Unkown
HY-148243	IGUANA-1 free base	Inhibitor	99.69%	Unkown
HY-157567	FSI-TN42	Inhibitor	98.05%	Unkown
HY-146240	ALDH1A1-IN-3	Inhibitor	/	Unkown
HY-155816	PROTAC NSD3 degrader-1		/	Unkown
HY-157872	ALDH1A1-IN-4	Inhibitor	/	Unkown
HY-158026	ALDH1A1-IN-5	Inhibitor	/	Unkown
HY-159111	KS124		/	Unkown
HY-18768A	NCT-501 hydrochloride	Inhibitor	/	Unkown
HY-RS00560	ALDH1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00561	Aldh1a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00562	ALDH1A1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00565	ALDH1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00566	ALDH1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ALDH1A1	NCBI	NCBI:216

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