ALDH1A1 - aldehyde dehydrogenase 1 family member A1 Gene

Homo sapiens

Also known as ALDC; ALDH1; HEL-9; HEL12; PUMB1; ALDH11; RALDH1; ALDH-E1; HEL-S-53e

Gene ID: 216 | Gene type: protein coding

About ALDH1A1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:72,900,671-72,953,053 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 17 paralogues. Broad expression in liver (RPKM 321.0), duodenum (RPKM 249.1) and 18 other tissues.

Summary

The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next Enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

ALDH1A1 Products(1)

mRNA	Protein	Name
NM_000689.5	NP_000680.2	aldehyde dehydrogenase 1A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3-deoxyglucosone dehydrogenase activity	IDA IDA: Inferred from direct assay	17175089	GOA
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	4015840	GOA
enables aldehyde dehydrogenase (NAD+) activity	IMP IMP: Inferred from mutant phenotype	15623782	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular detoxification of aldehyde	IMP IMP: Inferred from mutant phenotype	15623782	GOA
involved in fructosamine catabolic process	IDA IDA: Inferred from direct assay	17175089	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	12941160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALDH1A1 Protein Structure

Aldedh

0
100
200
300
400
501 a.a.

Protein Preferred Names

Protein Names

aldehyde dehydrogenase 1A1

3-deoxyglucosone dehydrogenase	ALDH class 1
ALHDII	RALDH 1
acetaldehyde dehydrogenase 1	aldehyde dehydrogenase 1, soluble
aldehyde dehydrogenase, liver cytosolic	epididymis luminal protein 12
epididymis luminal protein 9	epididymis secretory sperm binding protein Li 53e
retinal dehydrogenase 1	retinaldehyde dehydrogenase 1

ALDH1A1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ALDH1A1	P00352	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	ALDH1A1	P00352	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	ALDH1A1	P00352	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	ALDH1A1	P00352	GFAP	Homo sapiens	P14136	Y2H Pooling	32814053
Intra	ALDH1A1	P00352	GFAP	Homo sapiens	P14136	Validated Y2H	32814053
Intra	ALDH1A1	P00352	GFAP	Homo sapiens	P14136	Y2H Array	32814053
Intra	ALDH1A1	P00352	DBH	Homo sapiens	P09172	Y2H Pooling	32814053
Intra	ALDH1A1	P00352	DBH	Homo sapiens	P09172	Validated Y2H	32814053
Intra	ALDH1A1	P00352	DBH	Homo sapiens	P09172	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALDH1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7474	ALDH1A1 Protein, Human (His)	P00352 (M1-S501)	≥95%

Related Diseases

Diseases

Alias

Succinic Semialdehyde Dehydrogenase Deficiency

4-Hydroxybutyric Aciduria	Ssadh Deficiency
Gamma-Hydroxybutyric Aciduria	Gaba Metabolic Defect
SSADHD	Ssadh
Succinate-Semialdehyde Dehydrogenase Deficiency	Gamma-Hydroxybutyricaciduria
4-Hydroxybutyricaciduria	Gamma-Hydroxybutyric Acidemia
Succinate Semialdehyde Dehydrogenase Deficiency

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Leukemia, Myeloid, Acute	Acute Myeloid Leukemia, Somatic
Leukemia, Acute Myeloid, Somatic	Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic
Acute Myeloblastic Leukaemia	Acute Myelogenous Leukaemia
Aml - Acute Myeloid Leukemia	Acute Myeloid Leukemia With Cebpa Somatic Mutations
Aml With Cebpa Somatic Mutations	Inherited Acute Myeloid Leukemia
Familial Aml	Inherited Aml
Pure Familial Aml	Pure Familial Acute Myeloid Leukemia
Secondary Acute Myeloid Leukemia	Therapy-Related Aml And Myelodysplastic Syndrome
Acute Myeloid Leukemia, Secondary	Acute Non-Lymphoblastic Leukemia
Acute Non-Lymphocytic Leukemia	Acute Biphenotypic Leukemia
Acute Undifferentiated Leukemia	Acute Myeloblastic Leukaemia With Multilineage Dysplasia
Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission	Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Anaerobic Meningitis

Androgen Insensitivity Syndrome

Androgen Resistance Syndrome	AIS
Testicular Feminization Syndrome	Androgen Receptor Deficiency
Dihydrotestosterone Receptor Deficiency	Dhtr Deficiency
Ar Deficiency	Testicular Feminization
Tfm	Androgen Insensitivity
Androgen-Insensitivity Syndrome	Goldberg-Maxwell Syndrome
Complete Androgen Insensitivity Syndrome	Cais
Feminisation - Testicular	Goldberg - Maxwell Syndrome
Androgen Insensitivity Syndrome, Complete	Morris Syndrome
Ary	AR
Insensitivity Syndrome, Androgen	Androgen Insensitivity Nos

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against	Alcohol Dependence, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138097	α-NETA		≥98.0%	Unkown
HY-18768	NCT-501	Inhibitor	99.84%	Unkown
HY-148466	IGUANA-1	Inhibitor	98.88%	Unkown
HY-112278	NCT-506	Inhibitor	99.95%	Unkown
HY-123621	GNE-375	Inhibitor	99.81%	Unkown
HY-135841	CM010	Inhibitor	98.07%	Unkown
HY-112277	NCT-505	Inhibitor	99.37%	Unkown
HY-146683	KS106		99.31%	Unkown
HY-110294	CM037	Inhibitor	99.06%	Unkown
HY-146682	KS100		99.61%	Unkown
HY-122912	ALDH1A inhibitor 673A		99.15%	Unkown
HY-126003	ALDH1A1-IN-2	Inhibitor	99.31%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.30%	Unkown
HY-148243	IGUANA-1 free base	Inhibitor	99.69%	Unkown
HY-157567	FSI-TN42	Inhibitor	98.05%	Unkown
HY-146240	ALDH1A1-IN-3	Inhibitor	/	Unkown
HY-155816	PROTAC NSD3 degrader-1		/	Unkown
HY-157872	ALDH1A1-IN-4	Inhibitor	/	Unkown
HY-158026	ALDH1A1-IN-5	Inhibitor	/	Unkown
HY-159111	KS124		/	Unkown
HY-18768A	NCT-501 hydrochloride	Inhibitor	/	Unkown
HY-RS00560	ALDH1A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00561	Aldh1a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00562	ALDH1A1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00565	ALDH1B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00566	ALDH1L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALDH1A1	RGD	RGD:2087
Canis familiaris	ALDH1A1	VGNC	VGNC:37782
Felis catus	ALDH1A1	VGNC	VGNC:97345
Bos taurus	ALDH1A1	VGNC	VGNC:25808
Macaca mulatta	ALDH1A1	VGNC	VGNC:81351
Others	ALDH1A1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.