Syk - spleen associated tyrosine kinase Gene

Rattus norvegicus

Also known as p72syk

Gene ID: 25155 | Gene type: protein coding

About Syk

Primary_assembly 17: 12,604,619-12,661,410 reverse strand.mRatBN7.2:CM026990.1

This gene has 2 transcripts (splice variants), 202 orthologues, 32 paralogues and is associated with 9 phenotypes. Biased expression in Spleen (RPKM 486.2), Thymus (RPKM 76.4) and 4 other tissues.

Summary

Enables protein domain specific binding activity; protein tyrosine kinase activity; and ubiquitin protein Ligase binding activity. Involved in positive regulation of mast cell degranulation and protein autophosphorylation. Predicted to be located in early phagosome and nucleus. Predicted to be part of B cell receptor complex and T cell receptor complex. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Used to study anti-basement membrane glomerulonephritis. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human Syk (spleen associated tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Syk Products(1)

mRNA	Protein	Name
NM_012758.2	NP_036890.2	tyrosine-protein kinase SYK

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18579528	RGD
enables protein domain specific binding	IDA IDA: Inferred from direct assay	16861349	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	16861349	RGD
enables protein tyrosine kinase activity	EXP EXP: Inferred from Experiment	10931839	RGD
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	8920860	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	16861349	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	16861349	RGD
involved in regulation of immune response	IDA IDA: Inferred from direct assay	12417718	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Syk Protein Structure

SH2_N-SH2_Zap70_Syk_like

SH2_C-SH2_Syk_like

PTKc_Syk

0
100
200
300
400
500
629 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase SYK

spleen tyrosine kinase

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13038A	Fostamatinib	Inhibitor	99.50%	Yes
HY-13038	Fostamatinib Disodium	Inhibitor	99.88%	Yes
HY-13038B	Fostamatinib disodium hexahydrate	Inhibitor	99.73%	Yes

Clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15968	Entospletinib	Inhibitor	99.88%	Phase 3
HY-15999	Cerdulatinib	Inhibitor	99.06%	Phase 3
HY-15999A	Cerdulatinib hydrochloride	Inhibitor	99.89%	Phase 3
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Phase 2
HY-109091	Lanraplenib	Inhibitor	99.12%	Phase 2
HY-100867A	Mivavotinib monohydrochloride	Inhibitor	99.91%	Phase 2
HY-103018	Gusacitinib	Inhibitor	99.41%	Phase 2
HY-15322	PRT062607	Inhibitor	97.13%	Phase 2
HY-109082	Cevidoplenib	Inhibitor	99.58%	Phase 2
HY-109091B	Lanraplenib succinate	Inhibitor	98.58%	Phase 2
HY-100867	Mivavotinib	Inhibitor	/	Phase 2
HY-109091A	Lanraplenib monosuccinate	Inhibitor	/	Phase 2
HY-103018A	Gusacitinib hydrochloride	Inhibitor	/	Phase 2
HY-13518	Piceatannol	Inhibitor	98.90%	Phase 1
HY-112809	GSK2646264	Inhibitor	98.39%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12067	R406	Inhibitor	96.70%	Unkown
HY-11108	R406 free base	Inhibitor	99.80%	Unkown
HY-14985	BAY 61-3606 dihydrochloride	Inhibitor	99.91%	Unkown
HY-78263	MNS	Inhibitor	99.55%	Unkown
HY-12974	PRT-060318	Inhibitor	99.04%	Unkown
HY-112390A	Syk Inhibitor II	Inhibitor	98.15%	Unkown
HY-145598	Sovleplenib	Inhibitor	99.94%	Unkown
HY-16420	R112	Inhibitor	99.71%	Unkown
HY-76474A	BAY 61-3606 hydrochloride	Inhibitor	98.98%	Unkown
HY-16902	RO9021	Inhibitor	98.88%	Unkown
HY-18623	VI 16832	Ligand	98.82%	Unkown
HY-12736A	GSK143 dihydrochloride	Inhibitor	99.37%	Unkown
HY-136198	SRX3207	Inhibitor	98.50%	Unkown
HY-131341	Syk-IN-4	Inhibitor	≥98.0%	Unkown
HY-109082A	Cevidoplenib dimesylate	Inhibitor	98.96%	Unkown
HY-138961	ER-27319	Inhibitor	98.66%	Unkown
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-151634	Syk-IN-6	Inhibitor	/	Unkown
HY-108489	ER-27319 maleate	Inhibitor	≥99.4%	Unkown
HY-112386	OXSI-2	Inhibitor	95.00%	Unkown
HY-12657	Syk-IN-1	Inhibitor	99.18%	Unkown
HY-10230S	Midostaurin-d5	Inhibitor	≥98.0%	Unkown
HY-76474	BAY 61-3606	Inhibitor	98.21%	Unkown
HY-130680	Syk-IN-3	Inhibitor	/	Unkown
HY-12736	GSK143	Inhibitor	/	Unkown
HY-112390B	Syk Inhibitor II dihydrochloride dihydrate	Inhibitor	/	Unkown
HY-149895	Syk-IN-7	Inhibitor	/	Unkown
HY-155513	Syk-IN-8	Inhibitor	/	Unkown
HY-N3702	Dehydroabietinol	Inhibitor	/	Unkown
HY-P2504	Syk Kinase Peptide Substrate, Biotin labeled		/	Unkown
HY-162427	NMS-0963	Inhibitor	/	Unkown
HY-P2505	Syk Kinase Peptide Substrate		/	Unkown
HY-145029	SYK/JAK-IN-1	Inhibitor	/	Unkown
HY-112390C	Syk Inhibitor II hydrochloride	Inhibitor	/	Unkown
HY-120214	TAS05567	Inhibitor	/	Unkown
HY-112390	Syk Inhibitor II dihydrochloride	Inhibitor	/	Unkown
HY-112319	MK-8457	Inhibitor	/	Unkown
HY-169630	DBMB	Inhibitor	/	Unkown
HY-160930	TOP1288	Inhibitor	/	Unkown
HY-123625	R-348 choline	Inhibitor	/	Unkown
HY-N7314	Asebogenin	Inhibitor	/	Unkown
HY-124146	BI1002494	Inhibitor	/	Unkown
HY-120533	Syk-IN-11	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syk	NCBI	NCBI:6850

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