2. Gene
  3. Dpp4 - dipeptidylpeptidase 4 Gene

Dpp4 - dipeptidylpeptidase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CD26; DPPIV

Gene ID: 25253 | Gene type: protein coding

About Dpp4

Primary_assembly 3: 46,962,243-47,043,901 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 209 orthologues, 6 paralogues and is associated with 36 phenotypes. Biased expression in Kidney (RPKM 1492.6), Liver (RPKM 372.) and 3 other tissues.

Summary

Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in several processes, including B-1a B cell differentiation; proteolysis; and regulation of lymphocyte mediated immunity. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (Dipeptidyl Peptidase 4). [provided by Alliance of Genome Resources, Apr 2022]

Dpp4 Products(1)

mRNA Protein Name
NM_012789.2 NP_036921.2 dipeptidyl peptidase 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables collagen binding IDA
IDA: Inferred from direct assay
8526932 RGD
enables dipeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
10931192 RGD
enables dipeptidyl-peptidase activity IMP
IMP: Inferred from mutant phenotype
9210490 RGD
enables identical protein binding IMP
IMP: Inferred from mutant phenotype
9210490 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
10931192 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
17415460 RGD
Biological Process GO Annotation Evidence Reference Source
involved in B-1a B cell differentiation IMP
IMP: Inferred from mutant phenotype
19327106 RGD
involved in positive regulation of natural killer cell mediated immunity IMP
IMP: Inferred from mutant phenotype
19327106 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
17415460 RGD
involved in regulation of T cell mediated immunity IMP
IMP: Inferred from mutant phenotype
15606609 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
10931192 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dpp4 Protein Structure

DPPIV_rep

DPPIV_rep: pfam18811 (35 - 55)

DPPIV_N

DPPIV_N: pfam00930 (105 - 478)

Peptidase_S9

Peptidase_S9: pfam00326 (559 - 763)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 4

DPP IV

GP110 glycoprotein

T-cell activation antigen CD26

bile canaliculus domain-specific membrane glycoprotein

dipeptidyl peptidase IV

Related Agents

Approval
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13749 Sitagliptin Inhibitor 99.75% Yes
HY-10284 Linagliptin 99.91% Unkown
HY-13749A Sitagliptin phosphate Inhibitor 99.85% Yes
HY-10285 Saxagliptin Inhibitor 99.96% Yes
HY-15981 Omarigliptin Inhibitor 99.88% Unkown
HY-13749B Sitagliptin phosphate monohydrate Inhibitor 99.49% Yes
HY-14806 Teneligliptin Inhibitor 99.85% Unkown
HY-A0023 Alogliptin Benzoate Inhibitor 99.99% Unkown
HY-A0023A Alogliptin Inhibitor 99.92% Unkown
HY-14806B Teneligliptin hydrobromide hydrate Inhibitor 99.87% Unkown
HY-15408 Trelagliptin Inhibitor 99.54% Unkown
HY-14877 Anagliptin Inhibitor 99.91% Unkown
HY-15408A Trelagliptin succinate Inhibitor 99.96% Unkown
HY-14806A Teneligliptin hydrobromide Inhibitor 99.99% Unkown
HY-16448 Saxagliptin hydrochloride Inhibitor 99.71% Yes
HY-14892 Gemigliptin Inhibitor / Unkown
HY-108795A Albiglutide fragment TFA Agonist 99.12% Unkown
HY-10285A Saxagliptin hydrate Inhibitor ≥99.0% Yes
HY-14877A Anagliptin hydrochloride Inhibitor / Unkown
HY-108795 Albiglutide fragment Agonist / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9805 Anti-MERS-3A1 mAb Inhibitor / Unkown
HY-P9806 Anti-MERS-D12 mAb Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-117985B Evogliptin tartrate 99.71% Phase 4
HY-14806S Teneligliptin-d8 Inhibitor / Phase 4
HY-117985 Evogliptin / Phase 4
HY-10286 Dutogliptin Inhibitor 99.32% Phase 3
HY-112668 Retagliptin phosphate Inhibitor 99.89% Phase 3
HY-147257 Cofrogliptin Inhibitor 99.07% Phase 3
HY-10286A Dutogliptin tartrate Inhibitor / Phase 3
HY-12528 DBPR108 Inhibitor 98.75% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99466 Begelomab Inhibitor ≥95.0% Phase 3
Pre-clinical Phase
Bioactive Molecules (55)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P1141 GLP-1(9-36)amide Antagonist 99.78% Unkown
HY-14892A Gemigliptin tartrate Inhibitor 98.17% Unkown
HY-P2543 Neuropeptide Y (3-36) (human, rat) Agonist 95.78% Unkown
HY-112668A Retagliptin Inhibitor 98.51% Unkown
HY-N6079 Timosaponin A1 Inhibitor 99.24% Unkown
HY-P1141A GLP-1(9-36)amide TFA Antagonist 98.00% Unkown
HY-147401 Sitagliptin fenilalanil Inhibitor 99.76% Unkown
HY-13749AS Sitagliptin-d4 phosphate Inhibitor 99.48% Unkown
HY-123377A Fotagliptin benzoate Inhibitor 99.19% Unkown
HY-A0023AS1 Alogliptin-d3 Inhibitor 99.61% Unkown
HY-10284S Linagliptin-d4 99.62% Unkown
HY-124958 NDMC101 Inhibitor 99.91% Unkown
HY-13749S1 Sitagliptin-d4 hydrochloride / Unkown
HY-A0023AS Alogliptin-13C,d3 Inhibitor / Unkown
HY-RS03963 DPP4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-112668B Retagliptin hydrochloride / Unkown
HY-117985A Evogliptin hydrochloride Inhibitor / Unkown
HY-123377 Fotagliptin Inhibitor / Unkown
HY-147401A Sitagliptin fenilalanil hydrochloride Inhibitor 98.94% Unkown
HY-10284S1 Linagliptin-13C,d3 / Unkown
HY-10284S3 Linagliptin-d3-1 / Unkown
HY-120828 Albenatide Agonist / Unkown
HY-121029 Bisegliptin / Unkown
HY-125330 Denagliptin tosylate / Unkown
HY-13749C (S)-Sitagliptin phosphate Inhibitor / Unkown
HY-146455 DPP-4-IN-3 Inhibitor / Unkown
HY-146468 DPP-4/GPR119 modulator 1 / Unkown
HY-146469 DPP-4/GPR119 modulator 2 / Unkown
HY-14806S1 Teneligliptin-d4 Inhibitor / Unkown
HY-151383 DPP-4-IN-1 Inhibitor / Unkown
HY-151384 DPP-4-IN-2 Inhibitor / Unkown
HY-15408S Trelagliptin-13C,d3 Inhibitor / Unkown
HY-155027 DPP-4-IN-8 Inhibitor / Unkown
HY-155961 Antidiabetic agent 2 Inhibitor / Unkown
HY-157390 DPP-4-IN-9 Inhibitor / Unkown
HY-158315 NZ-97 Inhibitor / Unkown
HY-159491 DPP-4-IN-11 Inhibitor / Unkown
HY-161428 ZINC000003015356 Inhibitor / Unkown
HY-162513 DPP-4-IN-10 Inhibitor / Unkown
HY-163332 MPO-IN-6 Inhibitor / Unkown
HY-168621 DPP-4-IN-13 Inhibitor / Unkown
HY-169110 DPP-4-IN-12 Inhibitor / Unkown
HY-N9725 16-Hydroxycleroda-3,13-dien-15,16-olide Inhibitor / Unkown
HY-P6177 SGP8 Inhibitor / Unkown
HY-RS03964 Dpp4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03965 Dpp4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-103432 DPP4-In / Unkown
HY-109060 Garvagliptin Inhibitor / Unkown
HY-110051 DPP4-In hydrochloride / Unkown
HY-119266 HTS13517 Inhibitor / Unkown
HY-13749D (Rac)-Sitagliptin Inhibitor / Unkown
HY-139792 Besigliptin tosylate / Unkown
HY-16656 BMS-767778 Inhibitor / Unkown
HY-167680 Denagliptin / Unkown
HY-N8134 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dpp4 NCBI NCBI:1803
Macaca fascicularis Dpp4 NCBI NCBI:102133935
Mus musculus Dpp4 NCBI NCBI:13482