DPP4 - dipeptidyl peptidase 4 Gene

Homo sapiens

Also known as CD26; ADABP; ADCP2; DPPIV; TP103

Gene ID: 1803 | Gene type: protein coding

About DPP4

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:161,992,245-162,074,215 (from NCBI)

This gene has 23 transcripts (splice variants), 286 orthologues and 6 paralogues. Biased expression in small intestine (RPKM 70.7), placenta (RPKM 57.1) and 13 other tissues.

Summary

The DPP4 gene encodes Dipeptidyl Peptidase 4, which is identical to Adenosine Deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II Transmembrane Glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl Peptidase 4 is highly involved in glucose and Insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]

DPP4 Products(8)

mRNA	Protein	Name
NM_001935.4	NP_001926.2	dipeptidyl peptidase 4 isoform 1
NR_166823.1
NM_001379605.1	NP_001366534.1	dipeptidyl peptidase 4 isoform 3
NM_001379604.1	NP_001366533.1	dipeptidyl peptidase 4 isoform 2
NR_166825.1
NM_001379606.1	NP_001366535.1	dipeptidyl peptidase 4 isoform 4
NR_166824.1
NR_166822.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chemorepellent activity	IDA IDA: Inferred from direct assay	23677473	GOA
enables chemorepellent activity	IMP IMP: Inferred from mutant phenotype	23677473	GOA
enables dipeptidyl-peptidase activity	IDA IDA: Inferred from direct assay	10593948	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22001206	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	16651416	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7594462	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	14684150	GOA
enables serine-type endopeptidase activity	EXP EXP: Inferred from Experiment	8100523	GOA
enables serine-type peptidase activity	IDA IDA: Inferred from direct assay	14684150	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	10900005	GOA
enables virus receptor activity	IDA IDA: Inferred from direct assay	23486063	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in T cell activation	IDA IDA: Inferred from direct assay	7594462	GOA
involved in T cell costimulation	IDA IDA: Inferred from direct assay	10900005	GOA
involved in endothelial cell migration	IDA IDA: Inferred from direct assay	16651416	GOA
involved in negative regulation of extracellular matrix disassembly	IDA IDA: Inferred from direct assay	16651416	GOA
involved in negative regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	23677473	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17549790	GOA
involved in proteolysis	IDA IDA: Inferred from direct assay	27198182	GOA
involved in regulation of cell-cell adhesion mediated by integrin	IDA IDA: Inferred from direct assay	11772392	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	16670267	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	15052268	GOA
located in cell surface	IDA IDA: Inferred from direct assay	7594462	GOA
located in endocytic vesicle	IDA IDA: Inferred from direct assay	10900005	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	16651416	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16670267	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP4 Protein Structure

DPPIV_N

Peptidase_S9

0
200
400
600
766 a.a.

Protein Preferred Names

Protein Names

dipeptidyl peptidase 4

ADCP-2	DPP IV
Gly-Pro naphthylamidase	Post-proline dipeptidyl aminopeptidase IV
T-cell activation antigen CD26	Xaa-Pro-dipeptidylaminopeptidase
adenosine deaminase complexing protein 2	dipeptidyl peptidase IV
dipeptidylpeptidase 4	dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)

DPP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DPP4	P27487	CXCL2	Homo sapiens	P19875	Protease Assay	21314817
Intra	DPP4	P27487	CXCL2	Homo sapiens	P19875	Enzymatic Study	18275857
Cross	DPP4	P27487	S	Human MERS coronavirus	A0A2R4KP93	Filter Binding	29669833
Cross	DPP4	P27487	S	Human MERS coronavirus	A0A2R4KP93	Alpha-Screen	29669833
Cross	DPP4	P27487	S	Human MERS coronavirus	R9UQ53	Comigration in SDS	23835475
Cross	DPP4	P27487	S	Human MERS coronavirus	R9UQ53	GMS	23835475
Cross	DPP4	P27487	S	Human MERS coronavirus	R9UQ53	X-Ray Diffraction	23835475
Intra	DPP4	P27487	CXCL10	Homo sapiens	P02778	Enzymatic Study	18275857
Intra	DPP4	P27487	CXCL11	Homo sapiens	O14625	Protease Assay	21314817
Intra	DPP4	P27487	CCL11	Homo sapiens	P51671	Enzymatic Study	18275857
Intra	DPP4	P27487	CXCL10	Homo sapiens	P02778	Protease Assay	21314817
Intra	DPP4	P27487	DPP4	Homo sapiens	P27487	CD	22001206
Intra	DPP4	P27487	VIP	Homo sapiens	P01282	Protease Assay	21314817
Intra	DPP4	P27487	GCG	Homo sapiens	P01275	Protease Assay	21314817
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	SPR	32275855
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	Filter Binding	29669833
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	Alpha-Screen	29669833
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	FACS	32275855
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	Confocal	32275855
Intra	DPP4	P27487	S	Middle East respiratory syndrome-related coronavirus	K9N5Q8	FACS	32203189
Cross	DPP4	P27487	ADA	Bos taurus	P56658	SPR	22001206

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DPP4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70017	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, His)	P27487 (N29-P766)	≥95%
HY-P72975	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293)	P27487 (N29-P766)	≥95%
HY-P72976	CD26/Dipeptidyl Peptidase 4 Protein, Human (HEK293, Fc)	P27487 (N29-P766)	≥95%

Related Diseases

Diseases

Alias

Covid-19

2019 Novel Coronavirus	2019-Ncov Infection
Covid19	Sars-Cov-2 Infection
Wuhan Coronavirus Infection	Wuhan Seafood Market Pneumonia Virus Infection

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Pancreatic Colloid Cystadenoma

Mucinous Cystadenoma Of Pancreas

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Sezary'S Disease

Sezary Syndrome	Sézary Syndrome
Sezary'S Lymphoma	Sezary Disease
Sezary Erythroderma	Sezary Lymphoma

Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis	KPD
Diabetes Mellitus, Ketosis-Prone, Susceptibility To	Ketosis-Prone Diabetes Mellitus
Diabetes Mellitus, Insulin-Dependent	Diabetic Ketoacidosis Nos
Dka - [Diabetic Ketoacidosis] Nos	Dka - [Diabetic Ketoacidosis] Without Coma
Dka - [Diabetic Ketoacidosis] With Coma

Residual Stage Of Open Angle Glaucoma

Open-Angle Glaucoma Residual Stage

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Primary Cutaneous T-Cell Non-Hodgkin Lymphoma

Cutaneous T-Cell Lymphoma	Cutaneous T Cell Lymphoma
Lymphoma, T-Cell, Cutaneous	Ctcl
Lymphoma T-Cell Cutaneous

Middle East Respiratory Syndrome

Mers	Mers - [Middle East Respiratory Syndrome]

Eating Disorder

Eating Disorders

Feeding And Eating Disorders

Colon Adenocarcinoma

Adenocarcinoma Of Colon	Adenocarcinoma Of The Colon
Colonic Adenocarcinoma

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Fatty Liver Disease

Alcoholic Fatty Liver	Fatty Liver
Fatty Liver, Alcoholic	Fatty Change Of Liver
Hepatic Lipidosis	Steatosis Of Liver
Fatty Liver Alcoholic	Steatohepatitis
Etoh Fatty Liver	Etoh Fatty Liver Metamorphosis
Fatty Etoh Liver Necrosis

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Squamous Cell Bile Duct Carcinoma

Bile Duct Squamous Cell Carcinoma

Coronavirus Infectious Disease

Vulvovaginitis

Vulvo-Vaginitis

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Hyperinsulinism

Hyperinsulinemia

Autoimmune Disease Of Endocrine System

Acquired Metabolic Disease

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
BMIQ11	Obesity Bmiq11
Obesity, Early-Onset	Obesity , Susceptibility To
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

Anorexia Nervosa

Anorexia Nervosa, Susceptibility To	ANON
Anorexia Nervosa, Susceptibility To, 1	An
Anorexia Nervosa 1	An - [Anorexia Nervosa]

Bacterial Infectious Disease

Bacterial Infections	Bacterial Infection Nos
Disease Caused By Bacteria	Bacterial Disease Or Disorder

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Follicular Adenoma

Follicular Adenoma Of The Thyroid Gland	Thyroid Follicular Adenoma
Adenoma Follicular	Follicular Thyroid Adenoma
Thyroid Gland Follicular Adenoma

Bullous Pemphigoid

Benign Pemphigus	Senile Dermatitis Herpetiformis
Old Age Pemphigus	Parapemphigus
Pemphigoid	Pemphigoid Bullous
Pemphigoid, Bullous

Balanitis

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

Intermediate Coronary Syndrome

Unstable Angina	Angina At Rest
Anginal Chest Pain At Rest	Impending Infarction
Preinfarction Angina	Worsening Angina
Angina, Unstable	Myocardial Preinfarction Syndrome
Angina Unstable	Crescendo Angina
Angina Decubitus	Acute Coronary Insufficiency
Unstable Angina Pectoris	Preinfarctional Angina Pectoris
Worsening Effort Angina	Preinfarction Syndrome
Unstable Angina Pectoris Syndrome	Unstable Anginal Attack
Unstable Cardiac Angina	Unstable Chest Angina
Unstable Heart Angina	De Novo Effort Angina Pectoris
Crescendo Angina Pectoris	Ua - [Unstable Angina]

Psoriasis

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic	Lymphoma Lymphoblastic
Precursor Cell Lymphoblastic Lymphoma	Precursor Cell Lymphoblastic Leukemia Lymphoma

Leptin Deficiency Or Dysfunction

Morbid Obesity	Obesity Due To Congenital Leptin Deficiency
LEPD	Congenital Leptin Deficiency
Obesity, Morbid	Obesity, Morbid, Due To Leptin Deficiency
Severe Obesity	Obesity, Morbid, Nonsyndromic 1
Leptin Deficiency	Obesity, Severe, Due To Leptin Deficiency
Morbid Obesity Due To Leptin Deficiency	Obesity Morbid
Leptin Dysfunction	Leptin

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Carbohydrate Metabolic Disorder

Inborn Errors Of Carbohydrate Metabolism	Disorder Of Carbohydrate Metabolism
Carbohydrate Metabolism, Inborn Errors	Disorder Of Carbohydrate Transport And Metabolism
Inborn Carbohydrate Metabolism Disorder	Inborn Carbohydrate Metabolic Disorder
Carbohydrate Metabolism Disorder	Carbohydrate Metabolism Disorders
Disorders Of Carbohydrate Metabolism	Congenital Disorders Of Carbohydrate Metabolism
Inherited Disorders Of Carbohydrate Metabolism

Autonomic Neuropathy

Diabetic Autonomic Neuropathy

Diabetic Neuropathies

Hypoglycemic Coma

Glucose Metabolism Disease

Glucose Metabolism Disorders

Disorder Of Glucose Metabolism

Diabetes Mellitus

Diabetes

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Diabetes Mellitus, Non-Insulin-Dependent	Type 2 Diabetes
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Urinary Tract Infection

Urinary Tract Infections	Uti
Urinary Tract Infection Nos	Uti - [Urinary Tract Infection]
Uti Nos - [Urinary Tract Infection Nos]	Urosepsis Nos
E Coli Uti	E Coli Urinary Tract Infection
Escherichia Coli Uti

Inherited Metabolic Disorder

Inborn Errors Of Metabolism	Inborn Metabolism Disorder
Metabolic Hereditary Disorder	Inborn Error Of Metabolism
Inborn Metabolic Disorder	Metabolism, Inborn Errors

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Mycosis Fungoides

Mycosis Fungoides Lymphoma	Alibert-Bazin Syndrome
Granuloma Fungoides	Classic Mycosis Fungoides
Mycosis Fungoides, Alibert-Bazin Type

Adenosquamous Bile Duct Carcinoma

Bile Duct Adenosquamous Carcinoma

Non-Alcoholic Fatty Liver Disease

Fatty Liver	Non-Alcoholic Fatty Liver
Nafld	Nonalcoholic Fatty Liver Disease
Nonalcoholic Steatohepatitis	Steatosis
Nafl	Nash
Non-Alcoholic Steatohepatitis	Susceptibility To Nonalcoholic Fatty Liver Disease
Steatohepatitis	Fatty Degeneration
Non-Alcoholic Fatty Liver Disease Without Mention Of Non-Alcoholic Steatohepatitis	Nafld Without Nash
Nafld Without Mention Of Nash

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Human Immunodeficiency Virus Infectious Disease

Hiv Infections

Balanoposthitis

Balanitis Due To Infection

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Prediabetes Syndrome

Impaired Glucose Tolerance	Prediabetes
Prediabetic State	IGT
Igt - [Impaired Glucose Tolerance]	Impaired Glucose Tolerance With Unspecified Complication
Impaired Glucose Tolerance Without Complication	Abnormal Glucose Tolerance

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Hyperglycemia

Related Agents

Approval

Bioactive Molecules (20)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13749	Sitagliptin	Inhibitor	99.75%	Yes
HY-10284	Linagliptin		99.91%	Unkown
HY-13749A	Sitagliptin phosphate	Inhibitor	99.85%	Yes
HY-10285	Saxagliptin	Inhibitor	99.96%	Yes
HY-15981	Omarigliptin	Inhibitor	99.88%	Unkown
HY-13749B	Sitagliptin phosphate monohydrate	Inhibitor	99.49%	Yes
HY-14806	Teneligliptin	Inhibitor	99.85%	Unkown
HY-A0023	Alogliptin Benzoate	Inhibitor	99.99%	Unkown
HY-A0023A	Alogliptin	Inhibitor	99.92%	Unkown
HY-14806B	Teneligliptin hydrobromide hydrate	Inhibitor	99.87%	Unkown
HY-15408	Trelagliptin	Inhibitor	99.54%	Unkown
HY-14877	Anagliptin	Inhibitor	99.91%	Unkown
HY-15408A	Trelagliptin succinate	Inhibitor	99.96%	Unkown
HY-14806A	Teneligliptin hydrobromide	Inhibitor	99.99%	Unkown
HY-16448	Saxagliptin hydrochloride	Inhibitor	99.71%	Yes
HY-14892	Gemigliptin	Inhibitor	/	Unkown
HY-108795A	Albiglutide fragment TFA	Agonist	99.12%	Unkown
HY-10285A	Saxagliptin hydrate	Inhibitor	≥99.0%	Yes
HY-14877A	Anagliptin hydrochloride	Inhibitor	/	Unkown
HY-108795	Albiglutide fragment	Agonist	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P9805	Anti-MERS-3A1 mAb	Inhibitor	/	Unkown
HY-P9806	Anti-MERS-D12 mAb	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-117985B	Evogliptin tartrate		99.71%	Phase 4
HY-14806S	Teneligliptin-d8	Inhibitor	/	Phase 4
HY-117985	Evogliptin		/	Phase 4
HY-10286	Dutogliptin	Inhibitor	99.32%	Phase 3
HY-112668	Retagliptin phosphate	Inhibitor	99.89%	Phase 3
HY-147257	Cofrogliptin	Inhibitor	99.07%	Phase 3
HY-10286A	Dutogliptin tartrate	Inhibitor	/	Phase 3
HY-12528	DBPR108	Inhibitor	98.75%	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99466	Begelomab	Inhibitor	≥95.0%	Phase 3

Pre-clinical Phase

Bioactive Molecules (55)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1141	GLP-1(9-36)amide	Antagonist	99.78%	Unkown
HY-14892A	Gemigliptin tartrate	Inhibitor	98.17%	Unkown
HY-P2543	Neuropeptide Y (3-36) (human, rat)	Agonist	95.78%	Unkown
HY-112668A	Retagliptin	Inhibitor	98.51%	Unkown
HY-N6079	Timosaponin A1	Inhibitor	99.24%	Unkown
HY-P1141A	GLP-1(9-36)amide TFA	Antagonist	98.00%	Unkown
HY-147401	Sitagliptin fenilalanil	Inhibitor	99.76%	Unkown
HY-13749AS	Sitagliptin-d4 phosphate	Inhibitor	99.48%	Unkown
HY-123377A	Fotagliptin benzoate	Inhibitor	99.19%	Unkown
HY-A0023AS1	Alogliptin-d3	Inhibitor	99.61%	Unkown
HY-10284S	Linagliptin-d4		99.62%	Unkown
HY-124958	NDMC101	Inhibitor	99.91%	Unkown
HY-13749S1	Sitagliptin-d4 hydrochloride		/	Unkown
HY-A0023AS	Alogliptin-13C,d3	Inhibitor	/	Unkown
HY-RS03963	DPP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-112668B	Retagliptin hydrochloride		/	Unkown
HY-117985A	Evogliptin hydrochloride	Inhibitor	/	Unkown
HY-123377	Fotagliptin	Inhibitor	/	Unkown
HY-147401A	Sitagliptin fenilalanil hydrochloride	Inhibitor	98.94%	Unkown
HY-10284S1	Linagliptin-13C,d3		/	Unkown
HY-10284S3	Linagliptin-d3-1		/	Unkown
HY-120828	Albenatide	Agonist	/	Unkown
HY-121029	Bisegliptin		/	Unkown
HY-125330	Denagliptin tosylate		/	Unkown
HY-13749C	(S)-Sitagliptin phosphate	Inhibitor	/	Unkown
HY-146455	DPP-4-IN-3	Inhibitor	/	Unkown
HY-146468	DPP-4/GPR119 modulator 1		/	Unkown
HY-146469	DPP-4/GPR119 modulator 2		/	Unkown
HY-14806S1	Teneligliptin-d4	Inhibitor	/	Unkown
HY-151383	DPP-4-IN-1	Inhibitor	/	Unkown
HY-151384	DPP-4-IN-2	Inhibitor	/	Unkown
HY-15408S	Trelagliptin-13C,d3	Inhibitor	/	Unkown
HY-155027	DPP-4-IN-8	Inhibitor	/	Unkown
HY-155961	Antidiabetic agent 2	Inhibitor	/	Unkown
HY-157390	DPP-4-IN-9	Inhibitor	/	Unkown
HY-158315	NZ-97	Inhibitor	/	Unkown
HY-159491	DPP-4-IN-11	Inhibitor	/	Unkown
HY-161428	ZINC000003015356	Inhibitor	/	Unkown
HY-162513	DPP-4-IN-10	Inhibitor	/	Unkown
HY-163332	MPO-IN-6	Inhibitor	/	Unkown
HY-168621	DPP-4-IN-13	Inhibitor	/	Unkown
HY-169110	DPP-4-IN-12	Inhibitor	/	Unkown
HY-N9725	16-Hydroxycleroda-3,13-dien-15,16-olide	Inhibitor	/	Unkown
HY-P6177	SGP8	Inhibitor	/	Unkown
HY-RS03964	Dpp4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03965	Dpp4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-103432	DPP4-In		/	Unkown
HY-109060	Garvagliptin	Inhibitor	/	Unkown
HY-110051	DPP4-In hydrochloride		/	Unkown
HY-119266	HTS13517	Inhibitor	/	Unkown
HY-13749D	(Rac)-Sitagliptin	Inhibitor	/	Unkown
HY-139792	Besigliptin tosylate		/	Unkown
HY-16656	BMS-767778	Inhibitor	/	Unkown
HY-167680	Denagliptin		/	Unkown
HY-N8134	2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DPP4	RGD	RGD:2515
Bos taurus	DPP4	VGNC	VGNC:106715
Canis familiaris	DPP4	VGNC	VGNC:40074
Felis catus	DPP4	VGNC	VGNC:61604
Mus musculus	DPP4	MGD	MGI:94919
Macaca mulatta	DPP4	VGNC	VGNC:71979
Macaca fascicularis	DPP4	NCBI	NCBI:102133935
Others	DPP4	NCBI