2. Metabolic Enzyme/Protease
  3. Dipeptidyl Peptidase
  4. Fotagliptin benzoate

Fotagliptin benzoate  (Synonyms: SAL067)

Cat. No.: HY-123377A Purity: 99.19%
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Fotagliptin benzoate is a Dipeptidyl Peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). Fotagliptin benzoate displays great security in rat and dog. Fotagliptin benzoate can be used for Type 2 diabetes mellitus research.

For research use only. We do not sell to patients.

Fotagliptin benzoate Chemical Structure

Fotagliptin benzoate Chemical Structure

CAS No. : 1403496-40-1

Size Price Stock Quantity
5 mg USD 616 In-stock
10 mg USD 985 In-stock
25 mg USD 2070 In-stock
50 mg USD 3312 In-stock
100 mg USD 5300 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Fotagliptin benzoate:

Fotagliptin benzoate Related Antibodies

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Fotagliptin benzoate is a Dipeptidyl Peptidase IV (DPP-4) inhibitor (IC50=2.27 nM). Fotagliptin benzoate displays great security in rat and dog. Fotagliptin benzoate can be used for Type 2 diabetes mellitus research[1].

IC50 & Target[1]

DPP-4

22.7 nM (IC50)

In Vivo

Fotagliptin benzoate (33 mg/kg or 110 mg/kg) is safe for rat and dog at different doses respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

464.49

Formula

C24H25FN6O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(C1=CC=CC=C1)=O.CC(C2=O)=NN=C(N3C[C@@H](CCC3)N)N2CC4=C(C=CC(F)=C4)C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (215.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1529 mL 10.7645 mL 21.5290 mL
5 mM 0.4306 mL 2.1529 mL 4.3058 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (5.38 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1529 mL 10.7645 mL 21.5290 mL 53.8225 mL
5 mM 0.4306 mL 2.1529 mL 4.3058 mL 10.7645 mL
10 mM 0.2153 mL 1.0764 mL 2.1529 mL 5.3822 mL
15 mM 0.1435 mL 0.7176 mL 1.4353 mL 3.5882 mL
20 mM 0.1076 mL 0.5382 mL 1.0764 mL 2.6911 mL
25 mM 0.0861 mL 0.4306 mL 0.8612 mL 2.1529 mL
30 mM 0.0718 mL 0.3588 mL 0.7176 mL 1.7941 mL
40 mM 0.0538 mL 0.2691 mL 0.5382 mL 1.3456 mL
50 mM 0.0431 mL 0.2153 mL 0.4306 mL 1.0764 mL
60 mM 0.0359 mL 0.1794 mL 0.3588 mL 0.8970 mL
80 mM 0.0269 mL 0.1346 mL 0.2691 mL 0.6728 mL
100 mM 0.0215 mL 0.1076 mL 0.2153 mL 0.5382 mL
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Fotagliptin benzoate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fotagliptin1403496-40-1SAL067SAL 067SAL-067Dipeptidyl PeptidaseDPPDPP-4 inhibitorUPLC–MS/MSfotagliptinhuman plasmahuman urineInhibitorinhibitorinhibit

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