2. Gene
  3. Dyrk1a - dual specificity tyrosine phosphorylation regulated kinase 1A Gene

Dyrk1a - dual specificity tyrosine phosphorylation regulated kinase 1A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Dyrk; PSK47

Gene ID: 25255 | Gene type: protein coding

About Dyrk1a

Primary_assembly 11: 33,890,490-34,009,420 forward strand.mRatBN7.2:CM026984.1

This gene has 4 transcripts (splice variants), 236 orthologues, 11 paralogues and is associated with 20 phenotypes. Biased expression in Thymus (RPKM 179.), Muscle (RPKM 155.4) and 9 other tissues.

Summary

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in protein phosphorylation and regulation of RNA splicing. Located in nuclear speck. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk1a Products(1)

mRNA Protein Name
NM_012791.3 NP_036923.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28755400 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
11877424 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
8631952 RGD
enables protein serine/threonine kinase activity IGI
IGI: Inferred from genetic interaction
25556849 RGD
enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
8631952 RGD
Biological Process GO Annotation Evidence Reference Source
involved in calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
21273244 RGD
involved in cardiac muscle hypertrophy IEP
IEP: Inferred from expression pattern
19906449 RGD
involved in negative regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
27056896 RGD
involved in peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
21215488 RGD
involved in peptidyl-serine phosphorylation IGI
IGI: Inferred from genetic interaction
25556849 RGD
involved in peptidyl-threonine phosphorylation IGI
IGI: Inferred from genetic interaction
25556849 RGD
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
8631952 RGD
involved in positive regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
28377597 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
8631952 RGD
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
21273244 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
8631952 RGD
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: Inferred from direct assay
22767602 RGD
involved in regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
27056896 RGD
involved in regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
21273244 RGD
Cellular Component GO Annotation Evidence Reference Source
located in nuclear speck IDA
IDA: Inferred from direct assay
9748265 RGD
NOT located in nucleolus IDA
IDA: Inferred from direct assay
9748265 RGD
located in nucleus IDA
IDA: Inferred from direct assay
9748265 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dyrk1a Protein Structure

PKc_DYRK1

PKc_DYRK1: cd14226 (147 - 483)

  • 0
  • 200
  • 400
  • 600
  • 763 a.a.
Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 1A

Dual Specificity Yak1-related kinase

MNBH

RP86

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

protein kinase minibrain homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (63)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115470 CLK-IN-T3 Inhibitor 98.63% Unkown
HY-105309 GSK-626616 Inhibitor 99.77% Unkown
HY-132308 DYRK1-IN-1 Inhibitor 99.71% Unkown
HY-112296 T025 99.64% Unkown
HY-111380 EHT 1610 Inhibitor 98.16% Unkown
HY-101298 Paprotrain Inhibitor 99.87% Unkown
HY-142295 GNF2133 Inhibitor 98.49% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.56% Unkown
HY-108476 INDY Inhibitor 99.51% Unkown
HY-12838 RO5454948 Inhibitor 99.53% Unkown
HY-15951 ML167 Inhibitor 98.62% Unkown
HY-129492 GNF4877 Inhibitor 99.41% Unkown
HY-15569 NU6102 Inhibitor 99.23% Unkown
HY-135906 CK2/ERK8-IN-1 ≥99.0% Unkown
HY-101029 MBM-55 99.94% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-117049 Leucettine L41 Inhibitor 98.70% Unkown
HY-144290 ARN25068 Inhibitor 99.66% Unkown
HY-147066 Dyrk1A-IN-4 Inhibitor 99.90% Unkown
HY-110052 TBCA Inhibitor 99.45% Unkown
HY-147060 Dyrk1A-IN-3 Inhibitor 99.96% Unkown
HY-149262 CLK1-IN-3 98.03% Unkown
HY-156816 ON 108600 Inhibitor 99.73% Unkown
HY-128758A DYRKs-IN-1 hydrochloride Inhibitor 99.71% Unkown
HY-34222 7-Deazaguanine Inhibitor ≥99.0% Unkown
HY-P5430 DYRKtide 98.55% Unkown
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% Unkown
HY-12828A KH-CB20 Inhibitor 99.80% Unkown
HY-RS04095 Dyrk1a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-128758 DYRKs-IN-1 Inhibitor / Unkown
HY-155723 Leucettinib-92 Inhibitor / Unkown
HY-101029A MBM-55S / Unkown
HY-128759 DYRKs-IN-2 Inhibitor / Unkown
HY-129449 AnnH31 Inhibitor 99.91% Unkown
HY-139830 Dyrk1A-IN-1 Inhibitor / Unkown
HY-142295A GNF2133 hydrochloride Inhibitor / Unkown
HY-144614 JH-XVII-10 / Unkown
HY-144617 JH-XIV-68-3 Inhibitor / Unkown
HY-144695 Dyrk1A/α-synuclein-IN-1 Inhibitor / Unkown
HY-144696 Dyrk1A/α-synuclein-IN-2 Inhibitor / Unkown
HY-144826 ZDWX-25 Inhibitor / Unkown
HY-146337 Dyrk1A/B-IN-1 Inhibitor / Unkown
HY-146586 Haspin-IN-1 Inhibitor / Unkown
HY-146587 Haspin-IN-2 Inhibitor / Unkown
HY-147760 Dyrk1A-IN-2 Inhibitor / Unkown
HY-150537 AChE/GSK-3β-IN-1 Inhibitor / Unkown
HY-152183 FINDY Inhibitor / Unkown
HY-157995 Dyrk1A-IN-7 Inhibitor / Unkown
HY-158212 Dyrk1A-IN-8 Inhibitor / Unkown
HY-159496 Dyrk1A-IN-10 Inhibitor / Unkown
HY-163514 hAChE-IN-8 Inhibitor / Unkown
HY-168195 DYR530 / Unkown
HY-77324S 4-(Trifluoromethyl)aniline-d4 Inhibitor 99.23% Unkown
HY-N2892 Aristolactam A IIIa Inhibitor / Unkown
HY-P3992 5-FAM-Dyrktide / Unkown
HY-RS04094 DYRK1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04096 Dyrk1a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-108475 ProINDY Inhibitor / Unkown
HY-122989 Aristolactam BIII Inhibitor / Unkown
HY-162107 Dyrk1A-IN-6 Inhibitor / Unkown
HY-162597 Dyrk1A-IN-9 Inhibitor / Unkown
HY-168265 Dyrk1A-IN-11 Inhibitor / Unkown
HY-W067583 Norharmine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dyrk1a NCBI NCBI:1859