2. Gene
  3. ARRB1 - arrestin beta 1 Gene

ARRB1 - arrestin beta 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARB1; ARR1

Gene ID: 408 | Gene type: protein coding

About ARRB1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:75,260,122-75,351,661 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 3 paralogues. Broad expression in brain (RPKM 24.0), lung (RPKM 19.9) and 24 other tissues.

Summary

Members of Arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as Hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of Arrestin beta 1 have been described. [provided by RefSeq, Jan 2011]

ARRB1 Products(2)

mRNA Protein Name
NM_004041.5 NP_004032.2 beta-arrestin-1 isoform A
NM_020251.4 NP_064647.1 beta-arrestin-1 isoform B
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
15611106 GOA
enables angiotensin receptor binding IPI
IPI: Inferred from physical interaction
15611106 GOA
enables arrestin family protein binding IPI
IPI: Inferred from physical interaction
23886940 GOA
NOT enables histone acetyltransferase activity IDA
IDA: Inferred from direct assay
16325578 GOA
enables insulin-like growth factor receptor binding IPI
IPI: Inferred from physical interaction
15878855 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables transcription coactivator activity IMP
IMP: Inferred from mutant phenotype
16325578 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
15878855 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor internalization IMP
IMP: Inferred from mutant phenotype
10521508 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
16378096 GOA
involved in negative regulation of Notch signaling pathway IMP
IMP: Inferred from mutant phenotype
23886940 GOA
involved in negative regulation of interleukin-6 production IDA
IDA: Inferred from direct assay
16378096 GOA
involved in negative regulation of interleukin-8 production IDA
IDA: Inferred from direct assay
16378096 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: Inferred from direct assay
16378096 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
10644702 GOA
involved in positive regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
15611106 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
23633677 GOA
involved in positive regulation of receptor internalization IMP
IMP: Inferred from mutant phenotype
22457824 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16325578 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
15878855 GOA
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
15878855 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16325578 GOA
involved in stress fiber assembly IMP
IMP: Inferred from mutant phenotype
15611106 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
23886940 GOA
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
16325578 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
10823817 GOA
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
15611106 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16325578 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRB1 Protein Structure

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (19 - 174)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (194 - 356)

  • 0
  • 100
  • 200
  • 300
  • 418 a.a.
Protein Preferred Names Protein Names

beta-arrestin-1

arrestin 2

ARRB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ARRB1 P49407 PPM1B Homo sapiens O75688
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 ZRANB2 Homo sapiens O95218
Anti Bait CoIP
17353931
Intra
ARRB1 P49407 ZRANB2 Homo sapiens O95218
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 S100A9 Homo sapiens P06702
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 AP2B1 Homo sapiens P63010-2
Y2H Prey Pooling
32296183
Intra
ARRB1 P49407 AP2B1 Homo sapiens P63010-2
Y2H Array
32296183
Intra
ARRB1 P49407 AP2B1 Homo sapiens P63010-2
Validated Y2H
32296183
Intra
ARRB1 P49407 CD247 Homo sapiens P20963
Anti Tag CoIP
24502978
Intra
ARRB1 P49407 CD247 Homo sapiens P20963
IF
24502978
Intra
ARRB1 P49407 CD247 Homo sapiens P20963
Pull Down
24502978
Intra
ARRB1 P49407 NCL Homo sapiens P19338
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 GSN Homo sapiens P06396
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 HSPA8 Homo sapiens P11142
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 PKM Homo sapiens P14618
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 YWHAQ Homo sapiens P27348
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 TP53 Homo sapiens P04637
Anti Bait CoIP
21857681
Intra
ARRB1 P49407 MDM2 Homo sapiens Q00987
Anti Bait CoIP
21857681
Intra
ARRB1 P49407 GNAQ Homo sapiens P50148
Anti Tag CoIP
23353685
Intra
ARRB1 P49407 PRP4K Homo sapiens Q13523
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 TCOF1 Homo sapiens Q13428
Anti Bait CoIP
17353931
Intra
ARRB1 P49407 TCOF1 Homo sapiens Q13428
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 NOLC1 Homo sapiens Q14978
Anti Tag CoIP
33961781
Intra
ARRB1 P49407 NOLC1 Homo sapiens Q14978
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 NOLC1 Homo sapiens Q14978
Anti Bait CoIP
17353931
Intra
ARRB1 P49407 GNAS Homo sapiens Q5JWF2
Anti Bait CoIP
23353685
Intra
ARRB1 P49407 GNAS Homo sapiens Q5JWF2
Anti Tag CoIP
23353685
Intra
ARRB1 P49407 STK38 Homo sapiens Q15208
Anti Tag CoIP
17620599
Intra
ARRB1 P49407 MAP3K5 Homo sapiens Q99683
Peptide Array
19782076
Intra
ARRB1 P49407 SRC Homo sapiens P12931
Anti Bait CoIP
19202075
Intra
ARRB1 P49407 SRC Homo sapiens P12931
Anti Bait CoIP
16432186
Intra
ARRB1 P49407 EDNRA Homo sapiens P25101
Anti Bait CoIP
19202075
Intra
ARRB1 P49407 AXIN1 Homo sapiens O15169
Anti Bait CoIP
19202075
Intra
ARRB1 P49407 MAPK9 Homo sapiens P45984
Y2H Array
21988832
Intra
ARRB1 P49407 MAPK9 Homo sapiens P45984
Y2H
21988832
Intra
ARRB1 P49407 MAPK9 Homo sapiens P45984
Y2H Array
31515488
Intra
ARRB1 P49407 MAPK9 Homo sapiens P45984
Y2H Array
25416956
Intra
ARRB1 P49407 ZBTB43 Homo sapiens O43298
Y2H Pooling
16189514
Intra
ARRB1 P49407 ZBTB43 Homo sapiens O43298
Y2H Array
31515488
Intra
ARRB1 P49407 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
32296183
Intra
ARRB1 P49407 ZBTB43 Homo sapiens O43298
Y2H Array
32296183
Intra
ARRB1 P49407 GNMT Homo sapiens Q14749
Validated Y2H
32296183
Intra
ARRB1 P49407 GNMT Homo sapiens Q14749
Confocal
21988832
Intra
ARRB1 P49407 GNMT Homo sapiens Q14749
Y2H Array
32296183
Intra
ARRB1 P49407 GNMT Homo sapiens Q14749
Y2H Pooling
16189514
Intra
ARRB1 P49407 GNMT Homo sapiens Q14749
Y2H Array
31515488
Intra
ARRB1 P49407 GNMT Homo sapiens Q14749
Y2H Prey Pooling
32296183
Intra
ARRB1 P49407 YY1 Homo sapiens P25490
Y2H
19879840
Intra
ARRB1 P49407 YY1 Homo sapiens P25490
Anti Bait CoIP
19879840
Intra
ARRB1 P49407 YY1 Homo sapiens P25490
Anti Tag CoIP
19879840
Intra
ARRB1 P49407 PPM1A Homo sapiens P35813
Anti Tag CoIP
17620599
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARRB1 Proteins

Cat. No. Product Name Accession Purity
HY-P7606 ARRB1/Beta-Arrestin 1 Protein, Human (His) P49407 (M1-R418) ≥95%

Related Diseases

Diseases Alias
Placenta Praevia

Placenta Previa

Haemorrhage From Placenta Previa

Placenta Previa Haemorrhage

Lateral Placenta

Low Implantation Of Placenta Nos Or With Haemorrhage

Total Placenta Previa

Total Placenta Praevia Nos Or With Haemorrhage

Placental Previa Haemorrhage

Pp - [Placenta Previa]

Placenta Previa Marginalis

Placenta Previa Partialis

Partial Placenta Previa

Placenta Previa Centralis

Low Implantation Of Placenta

Low Implantation Or Insertion Of Placenta

Low Insertion Of Placenta

Low Lying Placenta

Marginal Placenta

Marginal Placenta Praevia Nos Or With Haemorrhage

Marginal Placenta Previa

Marginal Placental Haemorrhage

Partial Placenta Praevia Nos Or With Haemorrhage
Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD
Precocious Puberty, Central, 1

CPPB1

Central Precocious Puberty 1

Precocious Puberty, Central 1

Puberty, Precocious, Central, Type 1
Whim Syndrome 1

Whim Syndrome

Whims

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis

WHIMS1

Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome

Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1

Myelokathexis, Isolated

Wilm

Warts-Infections-Leukopenia-Myelokatexis Syndrome

Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Placental Abruption

Abruptio Placentae

Abruptio Placenta

Abortion, Threatened

Threatened Miscarriage

Haemorrhage Specified As Due To Threatened Abortion

Spontaneous Threatened Abortion
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Malignant Secondary Hypertension
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01028 ARRB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ARRB1 MGD MGI:99473
Bos taurus ARRB1 VGNC VGNC:26169
Macaca mulatta ARRB1 VGNC VGNC:70021
Felis catus ARRB1 VGNC VGNC:68263
Rattus norvegicus ARRB1 RGD RGD:2156
Canis familiaris ARRB1 VGNC VGNC:38136
Others ARRB1 NCBI