Arrb2 - arrestin, beta 2 Gene

Rattus norvegicus

Also known as BARRES

Gene ID: 25388 | Gene type: protein coding

About Arrb2

Summary

Enables several functions, including 14-3-3 protein binding activity; G protein-coupled receptor binding activity; and Arrestin family protein binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; regulation of apoptotic process; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; dendritic spine; and postsynaptic density. Biomarker of hypertension; portal hypertension; and type 2 diabetes mellitus. Orthologous to human ARRB2 (Arrestin beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Arrb2 Products(1)

mRNA	Protein	Name
NM_012911.2	NP_037043.1	beta-arrestin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 14-3-3 protein binding	IDA IDA: Inferred from direct assay	19008961	RGD
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	19200235	RGD
enables alpha-1A adrenergic receptor binding	IPI IPI: Inferred from physical interaction	18523139	RGD
enables alpha-1B adrenergic receptor binding	IDA IDA: Inferred from direct assay	18523139	RGD
enables arrestin family protein binding	IPI IPI: Inferred from physical interaction	23886940	RGD
enables follicle-stimulating hormone receptor binding	IPI IPI: Inferred from physical interaction	16899567	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	17984062	RGD
enables mitogen-activated protein kinase binding	IPI IPI: Inferred from physical interaction	19200235	RGD
enables platelet activating factor receptor binding	IPI IPI: Inferred from physical interaction	23911909	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15361545	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12890920	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15498833	RGD
enables type 1 angiotensin receptor binding	IPI IPI: Inferred from physical interaction	19522833	RGD
NOT enables type 2A serotonin receptor binding	IPI IPI: Inferred from physical interaction	19919577	RGD
enables type 2A serotonin receptor binding	IPI IPI: Inferred from physical interaction	19919577	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	157224	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	34919270	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	21926413	RGD
involved in endocytosis	IDA IDA: Inferred from direct assay	12600992	RGD
involved in follicle-stimulating hormone signaling pathway	IDA IDA: Inferred from direct assay	16899567	RGD
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	1517224	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	19171933	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	26621121	RGD
involved in negative regulation of opioid receptor signaling pathway	IDA IDA: Inferred from direct assay	34919270	RGD
involved in negative regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	20650893	RGD
involved in negative regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	19171933	RGD
involved in negative regulation of smooth muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19171933	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	19254952	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	19014370	RGD
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	21078978	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	28274926	RGD
involved in positive regulation of epithelial cell apoptotic process	IMP IMP: Inferred from mutant phenotype	24719556	RGD
involved in positive regulation of glial cell proliferation	IMP IMP: Inferred from mutant phenotype	19014370	RGD
involved in positive regulation of opioid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19014370	RGD
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	19171933	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IMP IMP: Inferred from mutant phenotype	19254952	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	19171933	RGD
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	19254952	RGD
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	16120787	RGD
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	1517224	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	12614678	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16899567	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	14757828	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	1517224	RGD
located in endosome	IDA IDA: Inferred from direct assay	14757828	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	1517224	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	1517224	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	157224	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-arrestin-2

Arrb2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Arrb2	P29067	MAP2K4	Homo sapiens	P45985	CoIP	11090355
Cross	Arrb2	P29067	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	17984062
Intra	Arrb2	P29067	MAPK1	Homo sapiens	P28482	Anti Tag CoIP	18191226
Intra	Arrb2	P29067	Mapk10	Rattus norvegicus	P49187	CoIP	11090355
Intra	Arrb2	P29067	FLNA	Homo sapiens	P21333	Anti Tag CoIP	17984062
Intra	Arrb2	P29067	Arrb2	Rattus norvegicus	P29067	FRET	17984062
Intra	Arrb2	P29067	Map3k5	Mus musculus	O35099	CoIP	11090355
Cross	Arrb2	P29067	AKT1	Homo sapiens	P31749	Anti Bait CoIP	18191226
Cross	Arrb2	P29067	LIMK1	Homo sapiens	P53667	Pull Down	17500066
Intra	Arrb2	P29067	Arrb2	Rattus norvegicus	P29067	BRET	17984062
Intra	Arrb2	P29067	Oprm1	Mus musculus	P42866	Anti Tag CoIP	17725581
Intra	Arrb2	P29067	Agtr1	Rattus norvegicus	P25095	BRET	16359671
Intra	Arrb2	P29067	GPR3	Homo sapiens	P46089	Anti Tag CoIP	24069330
Cross	Arrb2	P29067	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	18191226
Cross	Arrb2	P29067	AKT1	Homo sapiens	P31749	Pull Down	18191226
Intra	Arrb2	P29067	Rgs9	Mus musculus	O54828-1	Anti Bait CoIP	17725581
Intra	Arrb2	P29067	Arrb2	Rattus norvegicus	P29067	Anti Tag CoIP	17984062

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01029	ARRB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arrb2	NCBI	NCBI:409

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