Pkm - pyruvate kinase M1/2 Gene

Rattus norvegicus

Also known as PK; Pk3; Pkm2; PKM12

Gene ID: 25630 | Gene type: protein coding

About Pkm

Primary_assembly 8: 60,057,402-60,079,599 forward strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 229 orthologues, 5 paralogues and is associated with 10 phenotypes. Biased expression in Muscle (RPKM 9449.2), Heart (RPKM 2392.1) and 6 other tissues.

Summary

Enables several functions, including ADP binding activity; Pyruvate Kinase activity; and thyroid hormone binding activity. Involved in several processes, including ATP biosynthetic process; animal organ regeneration; and pyruvate metabolic process. Part of Pyruvate Kinase complex. Orthologous to human PKM (Pyruvate Kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]

Pkm Products(1)

mRNA	Protein	Name
NM_053297.2	NP_445749.1	pyruvate kinase PKM

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	7040662	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	1883388	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17877381	RGD
enables protein dimerization activity	IDA IDA: Inferred from direct assay	11687968	RGD
enables pyruvate kinase activity	IDA IDA: Inferred from direct assay	1883388	RGD
enables thyroid hormone binding	IDA IDA: Inferred from direct assay	1883388	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IDA IDA: Inferred from direct assay	4005043	RGD
involved in glucose metabolic process	IDA IDA: Inferred from direct assay	7929251	RGD
involved in glycolytic process	IDA IDA: Inferred from direct assay	1883388	RGD
involved in liver development	IDA IDA: Inferred from direct assay	7327170	RGD
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	10734049	RGD
involved in protein tetramerization	IDA IDA: Inferred from direct assay	11687968	RGD
involved in pyruvate biosynthetic process	IDA IDA: Inferred from direct assay	4273555	RGD
involved in pyruvate metabolic process	IDA IDA: Inferred from direct assay	10734049	RGD
involved in response to gravity	IEP IEP: Inferred from expression pattern	12165359	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	3696161	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	7929251	RGD
involved in response to muscle inactivity	IEP IEP: Inferred from expression pattern	6331066	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	7929251	RGD
involved in skeletal muscle tissue regeneration	IDA IDA: Inferred from direct assay	145474	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of pyruvate kinase complex	IDA IDA: Inferred from direct assay	1883388	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pkm Protein Structure

Pyruvate_Kinase

0
100
200
300
400
500
591 a.a.

Protein Preferred Names

Protein Names

pyruvate kinase PKM

M2 pyruvate kinase	pyruvate kinase isozymes M1/M2
pyruvate kinase muscle isozyme	pyruvate kinase, muscle
threonine-protein kinase PKM2	tyrosine-protein kinase PKM2

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1284	ZIP	Inhibitor	98.05%	Phase 4
HY-155785	MTP		/	Phase 4
HY-P1284A	ZIP TFA	Inhibitor	/	Phase 4

Pre-clinical Phase

Bioactive Molecules (36)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0822	Shikonin	Inhibitor	99.80%	Unkown
HY-18657	TEPP-46	Activator	99.93%	Unkown
HY-103617	PKM2-IN-1	Inhibitor	99.79%	Unkown
HY-19330	DASA-58	Activator	99.73%	Unkown
HY-126585	SAICAR		99.36%	Unkown
HY-147368	PKM2 activator 2	Activator	99.48%	Unkown
HY-D1456	TEPC466		99.43%	Unkown
HY-139667	PKM2-IN-3	Inhibitor	99.44%	Unkown
HY-N2552	Vitamin K5 hydrochloride		98.00%	Unkown
HY-157913	PKM2-IN-6		99.77%	Unkown
HY-148324	PKM2 activator 5	Activator	96.24%	Unkown
HY-155850	CIAC001	Inhibitor	99.70%	Unkown
HY-P1399A	Pep2m, myristoylated TFA	Inhibitor	99.77%	Unkown
HY-D1876	ZY-2		95.77%	Unkown
HY-156375	PKM2 activator 6		/	Unkown
HY-119874	Alkannin	Inhibitor	/	Unkown
HY-126585S	SAICAR-d1		/	Unkown
HY-147397	PKM2 activator 3	Activator	/	Unkown
HY-148313	PKM2 activator 4	Activator	/	Unkown
HY-148615	NPD10084	Inhibitor	/	Unkown
HY-149275	PKM2/PDK1-IN-1		/	Unkown
HY-155216	PKM2 activator 10		/	Unkown
HY-155668	HMG-CoA Reductase-IN-1	Inhibitor	/	Unkown
HY-161519	PKM2 activator 7	Activator	/	Unkown
HY-167832	PT109	Inhibitor	/	Unkown
HY-170577	PKM2-IN-8		/	Unkown
HY-B1814	Vitamin K5		/	Unkown
HY-D1877	ZY-1		98.91%	Unkown
HY-P1399	Pep2m, myristoylated	Inhibitor	/	Unkown
HY-RS10602	PKM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10603	Pkm Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10604	Pkm Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121275	Benserazide	Inhibitor	/	Unkown
HY-155849	PKM2-IN-4	Inhibitor	/	Unkown
HY-162071	PKM2-IN-5	Inhibitor	/	Unkown
HY-W587878	Thujopsene		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pkm	NCBI	NCBI:5315
Mus musculus	Pkm	NCBI	NCBI:18746

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