2. Gene
  3. Pkm - pyruvate kinase M1/2 Gene

Pkm - pyruvate kinase M1/2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PK; Pk3; Pkm2; PKM12

Gene ID: 25630 | Gene type: protein coding

About Pkm

Primary_assembly 8: 60,057,402-60,079,599 forward strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 229 orthologues, 5 paralogues and is associated with 10 phenotypes. Biased expression in Muscle (RPKM 9449.2), Heart (RPKM 2392.1) and 6 other tissues.

Summary

Enables several functions, including ADP binding activity; Pyruvate Kinase activity; and thyroid hormone binding activity. Involved in several processes, including ATP biosynthetic process; animal organ regeneration; and pyruvate metabolic process. Part of Pyruvate Kinase complex. Orthologous to human PKM (Pyruvate Kinase M1/2). [provided by Alliance of Genome Resources, Apr 2022]

Pkm Products(1)

mRNA Protein Name
NM_053297.2 NP_445749.1 pyruvate kinase PKM

Pkm Protein Structure

Pyruvate_Kinase

Pyruvate_Kinase: cd00288 (101 - 589)

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  • 591 a.a.
Protein Preferred Names Protein Names

pyruvate kinase PKM

M2 pyruvate kinase

pyruvate kinase isozymes M1/M2

pyruvate kinase muscle isozyme

pyruvate kinase, muscle

threonine-protein kinase PKM2

tyrosine-protein kinase PKM2

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P1284 ZIP Inhibitor 95.72% Phase 4
HY-P1284A ZIP TFA Inhibitor / Phase 4
Pre-clinical Phase
Bioactive Molecules (32)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0822 Shikonin Inhibitor 99.80% Unkown
HY-18657 TEPP-46 Activator 99.93% Unkown
HY-103617 PKM2-IN-1 Inhibitor 99.79% Unkown
HY-19330 DASA-58 Activator 99.73% Unkown
HY-126585 SAICAR 99.36% Unkown
HY-147368 PKM2 activator 2 Activator 99.48% Unkown
HY-157913 PKM2-IN-6 99.77% Unkown
HY-D1456 TEPC466 99.43% Unkown
HY-139667 PKM2-IN-3 Inhibitor 99.44% Unkown
HY-148324 PKM2 activator 5 Activator 96.24% Unkown
HY-P1399A Pep2m, myristoylated TFA Inhibitor 99.77% Unkown
HY-155850 CIAC001 Inhibitor 99.70% Unkown
HY-D1876 ZY-2 95.77% Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-119874 Alkannin Inhibitor / Unkown
HY-126585S SAICAR-d1 / Unkown
HY-147397 PKM2 activator 3 Activator / Unkown
HY-148313 PKM2 activator 4 Activator / Unkown
HY-148615 NPD10084 Inhibitor / Unkown
HY-149275 PKM2/PDK1-IN-1 / Unkown
HY-155668 HMG-CoA Reductase-IN-1 Inhibitor / Unkown
HY-155785 MTP / Unkown
HY-161519 PKM2 activator 7 Activator / Unkown
HY-B1814 Vitamin K5 Inhibitor / Unkown
HY-D1877 ZY-1 98.91% Unkown
HY-P1399 Pep2m, myristoylated Inhibitor / Unkown
HY-RS10602 PKM Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10603 Pkm Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10604 Pkm Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-121275 Benserazide Inhibitor / Unkown
HY-155849 PKM2-IN-4 Inhibitor / Unkown
HY-162071 PKM2-IN-5 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkm NCBI NCBI:5315
Mus musculus Pkm NCBI NCBI:18746