PKM - pyruvate kinase M1/2 Gene

Homo sapiens

Also known as PK3; TCB; p58; OIP3; PKM2; CTHBP; THBP1; HEL-S-30

Gene ID: 5315 | Gene type: protein coding

About PKM

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:72,199,029-72,231,591 (from NCBI)

This gene has 25 transcripts (splice variants), 294 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 155.4), esophagus (RPKM 151.3) and 24 other tissues.

Summary

This gene encodes a protein involved in glycolysis. The encoded protein is a Pyruvate Kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid Hormones. This protein has been found to bind Opa protein, a Bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in Bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

PKM Products(18)

mRNA	Protein	Name
XM_047432666.1	XP_047288622.1	pyruvate kinase PKM isoform X8
XM_047432663.1	XP_047288619.1	pyruvate kinase PKM isoform X2
NM_001206797.3	NP_001193726.1	pyruvate kinase PKM isoform d
XM_006720570.2	XP_006720633.1	pyruvate kinase PKM isoform X3
XM_047432665.1	XP_047288621.1	pyruvate kinase PKM isoform X7
XM_047432664.1	XP_047288620.1	pyruvate kinase PKM isoform X6
NM_001206798.3	NP_001193727.1	pyruvate kinase PKM isoform e
NM_182470.4	NP_872270.1	pyruvate kinase PKM isoform b
XM_047432662.1	XP_047288618.1	pyruvate kinase PKM isoform X1
NM_001206799.2	NP_001193728.1	pyruvate kinase PKM isoform f
XM_005254443.2	XP_005254500.1	pyruvate kinase PKM isoform X4
XM_005254445.6	XP_005254502.1	pyruvate kinase PKM isoform X8
NM_182471.4	NP_872271.1	pyruvate kinase PKM isoform b
NM_001316318.2	NP_001303247.1	pyruvate kinase PKM isoform g
NM_001206796.3	NP_001193725.1	pyruvate kinase PKM isoform c
NM_002654.6	NP_002645.3	pyruvate kinase PKM isoform a
NM_001411081.1	NP_001398010.1	pyruvate kinase PKM
XM_011521670.2	XP_011519972.1	pyruvate kinase PKM isoform X5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables histone H3T11 kinase activity	IDA IDA: Inferred from direct assay	22901803	GOA
enables histone H3T11 kinase activity	IDA IDA: Inferred from direct assay	22901803	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12620389	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	22306293	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	22306293	GOA
enables pyruvate kinase activity	IDA IDA: Inferred from direct assay	20005212	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	22056988	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in glycolytic process	IDA IDA: Inferred from direct assay	20847263	GOA
involved in positive regulation of sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	27199445	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22056988	GOA
involved in programmed cell death	IDA IDA: Inferred from direct assay	17308100	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	18298799	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	22901803	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17308100	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKM Protein Structure

PK_C

0
100
200
300
400
500
531 a.a.

Protein Preferred Names

Protein Names

pyruvate kinase PKM

OPA-interacting protein 3	PK, muscle type
cytosolic thyroid hormone-binding protein	epididymis secretory protein Li 30
pyruvate kinase 2/3	pyruvate kinase isozymes M1/M2
pyruvate kinase muscle isozyme	pyruvate kinase, muscle
threonine-protein kinase PKM2	thyroid hormone-binding protein 1
thyroid hormone-binding protein, cytosolic	tumor M2-PK
tyrosine-protein kinase PKM2

Recombinant PKM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7803	PKM2 Protein, Human (420 a.a, His)	P14618-1 (L61-E480)	≥95%
HY-P70599	PKM2 Protein, Human (530a.a, His)	P14618-1 (S2-P531)	≥95%

Related Diseases

Diseases

Alias

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Liver Carcinoma In Situ

Carcinoma In Situ Of Liver And Biliary System

Carcinoma In Situ Of Liver, Gallbladder And Bile Ducts

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Pyruvate Kinase Deficiency Of Red Cells

Pyruvate Kinase Deficiency	Pk Deficiency
Pyruvate Kinase Deficiency Of Erythrocyte	Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
Pyruvate Kinase Deficiency Of Erythrocytes	Pkd
PKRD	Hereditary Non-Spherocytic Hemolytic Anemia Due To Pyruvate Kinase Deficiency
Hnsha	Pyruvate Kinase-Deficient Hemolytic Anemia
Red Cell Pyruvate Kinase Deficiency	Deficiency Of Pyruvate Kinase
Anemia, Hemolytic, Congenital Nonspherocytic

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Neonatal Jaundice

Neonatal Hyperbilirubinemia	Neonatal Icterus
Jaundice Neonatal	Jaundice, Neonatal
Hyperbilirubinemia, Neonatal

Blood Group Incompatibility

Anterior Dislocation Of Lens

Congenital Nonspherocytic Hemolytic Anemia

Hereditary Nonspherocytic Hemolytic Anemia	Hereditary Non-Spherocytic Hemolytic Anemia
Anemia, Hemolytic, Congenital Nonspherocytic	Congenital Nonspherocytic Hemolytic Anaemia
Hereditary Nonspherocytic Hemolytic Anaemia	Hnsha

Pigmentation Disease

Pigmentation Disorders

Skin Pigmentation Disorder

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Kernicterus

Bilirubin Encephalopathy	Hyperbilirubinemic Encephalopathy
Kernicterus Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1284	ZIP	Inhibitor	95.72%	Phase 4
HY-P1284A	ZIP TFA	Inhibitor	/	Phase 4

Pre-clinical Phase

Bioactive Molecules (34)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0822	Shikonin	Inhibitor	99.80%	Unkown
HY-18657	TEPP-46	Activator	99.93%	Unkown
HY-103617	PKM2-IN-1	Inhibitor	99.79%	Unkown
HY-19330	DASA-58	Activator	99.73%	Unkown
HY-126585	SAICAR		99.36%	Unkown
HY-147368	PKM2 activator 2	Activator	99.48%	Unkown
HY-157913	PKM2-IN-6		99.77%	Unkown
HY-D1456	TEPC466		99.43%	Unkown
HY-139667	PKM2-IN-3	Inhibitor	99.44%	Unkown
HY-148324	PKM2 activator 5	Activator	96.24%	Unkown
HY-P1399A	Pep2m, myristoylated TFA	Inhibitor	99.77%	Unkown
HY-155850	CIAC001	Inhibitor	99.70%	Unkown
HY-D1876	ZY-2		95.77%	Unkown
HY-156375	PKM2 activator 6		/	Unkown
HY-119874	Alkannin	Inhibitor	/	Unkown
HY-126585S	SAICAR-d1		/	Unkown
HY-147397	PKM2 activator 3	Activator	/	Unkown
HY-148313	PKM2 activator 4	Activator	/	Unkown
HY-148615	NPD10084	Inhibitor	/	Unkown
HY-149275	PKM2/PDK1-IN-1		/	Unkown
HY-155216	PKM2 activator 10		/	Unkown
HY-155668	HMG-CoA Reductase-IN-1	Inhibitor	/	Unkown
HY-155785	MTP		/	Unkown
HY-161519	PKM2 activator 7	Activator	/	Unkown
HY-167832	PT109	Inhibitor	/	Unkown
HY-B1814	Vitamin K5	Inhibitor	/	Unkown
HY-D1877	ZY-1		98.91%	Unkown
HY-P1399	Pep2m, myristoylated	Inhibitor	/	Unkown
HY-RS10602	PKM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10603	Pkm Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10604	Pkm Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121275	Benserazide	Inhibitor	/	Unkown
HY-155849	PKM2-IN-4	Inhibitor	/	Unkown
HY-162071	PKM2-IN-5	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	PKM	VGNC	VGNC:55132
Rattus norvegicus	PKM	RGD	RGD:3337
Mus musculus	PKM	MGD	MGI:97591
Others	PKM	NCBI

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