Smad3 - SMAD family member 3 Gene

Rattus norvegicus

Also known as mad3; Madh3; Smad 3

Gene ID: 25631 | Gene type: protein coding

About Smad3

Summary

Enables several functions, including DNA-binding transcription factor activity; SMAD binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of hydrolase activity; regulation of gene expression; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytoplasm and nucleus. Part of transcription regulator complex. Used to study pre-malignant neoplasm. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 3; Lynch syndrome; and pancreatic Cancer. Orthologous to human SMAD3 (Smad Family member 3). [provided by Alliance of Genome Resources, Apr 2022]

Smad3 Products(1)

mRNA	Protein	Name
NM_013095.3	NP_037227.1	mothers against decapentaplegic homolog 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12702545	RGD
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	22073128	RGD
enables beta-catenin binding	IDA IDA: Inferred from direct assay	20097766	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	22073128	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16362038	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12702545	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in SMAD protein signal transduction	IMP IMP: Inferred from mutant phenotype	22073128	RGD
involved in activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	11839804	RGD
involved in adrenal gland development	IDA IDA: Inferred from direct assay	12844345	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	32065356	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	33409963	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	14517210	RGD
involved in negative regulation of cardiac muscle hypertrophy in response to stress	IGI IGI: Inferred from genetic interaction	27038547	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15987742	RGD
involved in negative regulation of lung blood pressure	IGI IGI: Inferred from genetic interaction	27038547	RGD
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	16690606	RGD
involved in negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	20097766	RGD
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16205635	RGD
involved in positive regulation of alkaline phosphatase activity	IDA IDA: Inferred from direct assay	12096832	RGD
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	12096832	RGD
involved in positive regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20097766	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17545585	RGD
involved in positive regulation of focal adhesion assembly	IDA IDA: Inferred from direct assay	15987742	RGD
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16371439	RGD
involved in positive regulation of nitric oxide biosynthetic process	IGI IGI: Inferred from genetic interaction	27038547	RGD
involved in positive regulation of positive chemotaxis	IDA IDA: Inferred from direct assay	15987742	RGD
involved in positive regulation of stress fiber assembly	IDA IDA: Inferred from direct assay	15987742	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12702545	RGD
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16891311	RGD
involved in positive regulation of transforming growth factor beta3 production	IMP IMP: Inferred from mutant phenotype	16891311	RGD
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	20097766	RGD
involved in signal transduction involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22073128	RGD
involved in transdifferentiation	IDA IDA: Inferred from direct assay	15987742	RGD
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16371439	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	16690606	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16891311	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mothers against decapentaplegic homolog 3

MAD (mothers against decapentaplegic, Drosophila) homolog 3	MAD homolog 3
mothers against DPP homolog 3

Smad3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Smad3	P84025	Akt1	Rattus norvegicus	P47196	Anti Tag CoIP	16362038
Intra	Smad3	P84025	Akt1	Rattus norvegicus	P47196	Anti Bait CoIP	16362038
Cross	Smad3	P84025	N	Human SARS coronavirus	P59595	Pull Down	18055455

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13013	SIS3	Inhibitor	98.71%	Unkown
HY-12953	R-268712	Inhibitor	99.88%	Unkown
HY-W012977	3,3-Dimethyl-1-butanol	Inhibitor	99.56%	Unkown
HY-47888	PLN-1474	Inhibitor	99.30%	Unkown
HY-18758	IN-1130	Inhibitor	99.93%	Unkown
HY-N2033	Chebulinic acid	Inhibitor	99.68%	Unkown
HY-100444	SIS3 free base	Inhibitor	98.11%	Unkown
HY-144043	ALK5-IN-8	Inhibitor	98.06%	Unkown
HY-147025	(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine		99.06%	Unkown
HY-114495	Caerulomycin A	Inhibitor	≥98.0%	Unkown
HY-128439	BT173	Inhibitor	98.71%	Unkown
HY-114683	KS370G		99.71%	Unkown
HY-146434	TGFβ-IN-2	Inhibitor	99.37%	Unkown
HY-163536	TGF-β1/Smad3-IN-1	Inhibitor	98.05%	Unkown
HY-W803134	(E/Z)-SIS3 free base	Inhibitor	99.48%	Unkown
HY-P10363	Tiger17	Activator	/	Unkown
HY-RS13394	SMAD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W108953	Myristoyl tetrapeptide-12	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Smad3	NCBI	NCBI:4088
Mus musculus	Smad3	NCBI	NCBI:17127

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