Akt1 - AKT serine/threonine kinase 1 Gene

Rattus norvegicus

Also known as Akt

Gene ID: 24185 | Gene type: protein coding

About Akt1

Primary_assembly 6: 131,713,720-131,733,921 reverse strand.mRatBN7.2:CM026979.1

This gene has 5 transcripts (splice variants), 219 orthologues, 5 paralogues and is associated with 108 phenotypes. Biased expression in Heart (RPKM 317.3), Adrenal (RPKM 243.5) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; GTPase activating protein binding activity; and Enzyme binding activity. Involved in several processes, including cellular macromolecule biosynthetic process; cellular response to mechanical stimulus; and regulation of cellular protein metabolic process. Acts upstream of or within several processes, including cellular response to Insulin stimulus; negative regulation of cell size; and positive regulation of sodium ion transport. Located in cytosol; mitochondrion; and nucleus. Used to study autosomal recessive polycystic kidney disease; hypertension; impotence; myocardial infarction; and type 2 diabetes mellitus. Biomarker of several diseases, including brain ischemia; colon cancer; diabetic retinopathy; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast Cancer (multiple); lung disease (multiple); pancreatic Cancer (multiple); and reproductive organ Cancer (multiple). Orthologous to human Akt1 (Akt serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Akt1 Products(2)

mRNA	Protein	Name
NM_033230.3	NP_150233.1	RAC-alpha serine/threonine-protein kinase
NM_033230.3	NP_150233.1	RAC-alpha serine/threonine-protein kinase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9887206	RGD
enables GTPase activating protein binding	IPI IPI: Inferred from physical interaction	14707121	RGD
enables enzyme binding	IPI IPI: Inferred from physical interaction	10454575	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12194869	RGD
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	7488143	RGD
enables protein kinase activity	IDA IDA: Inferred from direct assay	12084817	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	24583056	RGD
enables protein phosphatase 2A binding	IPI IPI: Inferred from physical interaction	11884620	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8524413	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	8524413	RGD
enables protein serine/threonine kinase inhibitor activity	IPI IPI: Inferred from physical interaction	8524413	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	20605787	RGD
acts upstream of or within cell projection organization	IDA IDA: Inferred from direct assay	16286931	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	20515660	RGD
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	9065430	RGD
acts upstream of or within cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	17715136	RGD
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	10454575	RGD
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	20042609	RGD
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	20605787	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	9492284	RGD
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	11812651	RGD
involved in glycogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	10400692	RGD
involved in insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	8524413	RGD
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9632753	RGD
involved in negative regulation of JNK cascade	IDA IDA: Inferred from direct assay	17064355	RGD
involved in negative regulation of calcium import into the mitochondrion	IMP IMP: Inferred from mutant phenotype	24601882	RGD
acts upstream of or within negative regulation of cell size	IDA IDA: Inferred from direct assay	16286931	RGD
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	8524413	RGD
involved in negative regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	24601882	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	8524413	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	20403980	RGD
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	12084817	RGD
involved in positive regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	24601882	RGD
involved in positive regulation of protein metabolic process	IMP IMP: Inferred from mutant phenotype	9632753	RGD
acts upstream of or within positive regulation of sodium ion transport	IMP IMP: Inferred from mutant phenotype	17715136	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	21532183	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9887206	RGD
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	24601882	RGD
involved in regulation of cell migration	IMP IMP: Inferred from mutant phenotype	17109063	RGD
acts upstream of or within regulation of protein localization	IMP IMP: Inferred from mutant phenotype	17715136	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	24601882	RGD
involved in spinal cord development	IDA IDA: Inferred from direct assay	23681769	RGD
involved in translation	IMP IMP: Inferred from mutant phenotype	9632753	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	31071414	RGD
located in nucleus	IDA IDA: Inferred from direct assay	20605787	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Akt1 Protein Structure

PH_PKB

STKc_PKB_alpha

0
100
200
300
400
480 a.a.

Protein Preferred Names

Protein Names

RAC-alpha serine/threonine-protein kinase

AKT1 kinase	PKB alpha
RAC protein kinase alpha RAC-PK alpha	RAC-PK-alpha
murine thymoma viral (v-akt) oncogene homolog 1	protein kinase B alpha
thymoma viral proto-oncogene 1	v-akt murine thymoma viral oncogene homolog 1

Akt1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Akt1	P47196	Gapdh	Rattus norvegicus	P04797	Anti Bait CoIP	20488185
Intra	Akt1	P47196	Smad3	Rattus norvegicus	P84025	Anti Tag CoIP	16362038
Intra	Akt1	P47196	Smad2	Rattus norvegicus	O70436	Anti Tag CoIP	16362038
Intra	Akt1	P47196	Smad2	Rattus norvegicus	O70436	Anti Bait CoIP	16362038
Intra	Akt1	P47196	Nfkb1	Rattus norvegicus	Q63369	Anti Bait CoIP	16642037
Intra	Akt1	P47196	Nfkb1	Rattus norvegicus	Q63369	Anti Tag CoIP	16642037
Intra	Akt1	P47196	Nfkb1	Rattus norvegicus	Q63369	Pull Down	16642037

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Clinical Phase

Bioactive Molecules (21)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15186	Ipatasertib		99.88%	Phase 4
HY-N0004	Oridonin	Inhibitor	99.89%	Phase 4
HY-15431	Capivasertib	Inhibitor	99.95%	Phase 3
HY-15186A	Ipatasertib dihydrochloride	Inhibitor	99.27%	Phase 3
HY-10358	MK-2206 dihydrochloride		99.99%	Phase 2
HY-19719	Miransertib	Inhibitor	99.32%	Phase 2
HY-15727	Afuresertib	Inhibitor	99.53%	Phase 2
HY-15965	Uprosertib	Inhibitor	99.74%	Phase 2
HY-19934A	Pifusertib hydrochloride		96.71%	Phase 2
HY-15727A	Afuresertib hydrochloride	Inhibitor	99.95%	Phase 2
HY-19719A	Miransertib hydrochloride	Inhibitor	99.74%	Phase 2
HY-108232	MK-2206		/	Phase 2
HY-19934	Pifusertib		/	Phase 2
HY-10357	MK-2206 free base		/	Phase 2
HY-15965A	Uprosertib hydrochloride	Inhibitor	/	Phase 2
HY-10249	GSK-690693		99.03%	Phase 1
HY-100018	BAY1125976	Inhibitor	99.52%	Phase 1
HY-16071	AT13148	Inhibitor	99.21%	Phase 1
HY-100501	M2698	Inhibitor	99.87%	Phase 1
HY-137458	Vevorisertib	Inhibitor	/	Phase 1
HY-15186C	Ipatasertib tosylate		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (68)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18749	SC79	Activator	≥98.0%	Unkown
HY-10355	AKT inhibitor VIII		98.97%	Unkown
HY-107738	Guggulsterone		99.95%	Unkown
HY-10425	A-443654	Inhibitor	99.71%	Unkown
HY-11005	BX-912		99.13%	Unkown
HY-N1435	Oroxin B		99.71%	Unkown
HY-13254	A-674563	Inhibitor	99.87%	Unkown
HY-124379	TPCK		98.55%	Unkown
HY-12059	AT7867	Inhibitor	99.88%	Unkown
HY-133120	INY-03-041	Inhibitor	99.74%	Unkown
HY-137458A	Vevorisertib trihydrochloride	Inhibitor	99.13%	Unkown
HY-151504	ALM301	Inhibitor	99.65%	Unkown
HY-18271	CaMKII-IN-1	Inhibitor	98.02%	Unkown
HY-160093	SQLE-IN-1		98.82%	Unkown
HY-145282	MS170	Inhibitor	99.72%	Unkown
HY-12059A	AT7867 dihydrochloride	Inhibitor	99.75%	Unkown
HY-13254A	A-674563 hydrochloride	Inhibitor	99.86%	Unkown
HY-151613A	MS15 TFA	Degrader	99.86%	Unkown
HY-16666	3CAI	Inhibitor	98.32%	Unkown
HY-50862	Akt1/Akt2-IN-1	Inhibitor	99.30%	Unkown
HY-19982	AKT-IN-6	Inhibitor	99.08%	Unkown
HY-119016	SK1-I	Inhibitor	98.47%	Unkown
HY-126257	AKT-IN-3	Inhibitor	99.29%	Unkown
HY-133120A	INY-03-041 trihydrochloride	Inhibitor	99.27%	Unkown
HY-107586	Demethylasterriquinone B1	Activator	98.10%	Unkown
HY-134903	(32-Carbonyl)-RMC-5552	Inhibitor	95.41%	Unkown
HY-119016A	SK1-I hydrochloride	Inhibitor	99.49%	Unkown
HY-N8122	24-Methylenecycloartanyl ferulate	Inhibitor	98.05%	Unkown
HY-130985	9-Decyn-1-ol		/	Unkown
HY-151613	MS15	Inhibitor	/	Unkown
HY-132302	Hu7691	Inhibitor	/	Unkown
HY-123390	DB07107	Inhibitor	/	Unkown
HY-129119	Akt1/Akt2-IN-2		98.57%	Unkown
HY-146459	Akt1-IN-1	Inhibitor	99.74%	Unkown
HY-148868	Akt1&PKA-IN-1	Inhibitor	/	Unkown
HY-148868A	Akt1&PKA-IN-2	Inhibitor	/	Unkown
HY-161321	PTP1B-IN-24		95.01%	Unkown
HY-P5910	Azurin p28 peptide	Inducer	/	Unkown
HY-W013816	Dipentyl phthalate		99.42%	Unkown
HY-W998345	SMART1	Inhibitor	99.31%	Unkown
HY-145281	MS98	Inhibitor	/	Unkown
HY-112148	AKT-IN-2	Inhibitor	/	Unkown
HY-132302A	Hu7691 free base	Inhibitor	/	Unkown
HY-123035	Gamendazole	Inhibitor	/	Unkown
HY-138767	AKT-IN-5	Inhibitor	/	Unkown
HY-143611	AKT-IN-8	Inhibitor	/	Unkown
HY-145244	APN/AKT-IN-1	Inhibitor	/	Unkown
HY-147937	AKT-IN-13	Inhibitor	/	Unkown
HY-153640	AKT-IN-14	Inhibitor	/	Unkown
HY-153640A	AKT-IN-14 free base	Inhibitor	/	Unkown
HY-154960	Tubulin/AKT1-IN-1		/	Unkown
HY-161438	Akt1-IN-3	Inhibitor	/	Unkown
HY-161439	Akt1-IN-4	Inhibitor	/	Unkown
HY-162285	Anticancer agent 189	Inhibitor	/	Unkown
HY-163577	Akt1-IN-5	Inhibitor	/	Unkown
HY-163578	Akt1-IN-6	Inhibitor	/	Unkown
HY-163579	Akt1-IN-7	Inhibitor	/	Unkown
HY-168049	ZLY06	Agonist	/	Unkown
HY-168205	HSP90-IN-33		/	Unkown
HY-P5910A	Azurin p28 peptide TFA	Inducer	/	Unkown
HY-RS00542	AKT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00543	Akt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00544	Akt1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00545	AKT1S1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W750451	Reptoside		/	Unkown
HY-16032	Akt1-IN-2	Inhibitor	/	Unkown
HY-162102	DDR1-IN-8	Inhibitor	/	Unkown
HY-169960	2DII	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Akt1	NCBI	NCBI:207

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