2. Gene
  3. GCA - grancalcin Gene

GCA - grancalcin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GCL

Gene ID: 25801 | Gene type: protein coding

About GCA

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:162,318,763-162,375,396 (from NCBI)

This gene has 10 transcripts (splice variants), 205 orthologues and 20 paralogues. Broad expression in bone marrow (RPKM 47.3), appendix (RPKM 18.4) and 18 other tissues.

Summary

This gene encodes a calcium-binding protein that is abundant in neutrophils and macrophages. In the absence of divalent cation, this protein localizes to the cytosolic fraction; with magnesium alone, it partitions with the granule fraction; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions. Alternative splicing and use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Aug 2016]

GCA Products(7)

mRNA Protein Name
NM_001330265.1 NP_001317194.1 grancalcin isoform a
NM_001330266.1 NP_001317195.1 grancalcin isoform a
NM_001330267.1 NP_001317196.1 grancalcin isoform a
NM_001330268.1 NP_001317197.1 grancalcin isoform c
NM_001330270.2 NP_001317199.1 grancalcin isoform d
NM_001330271.2 NP_001317200.1 grancalcin isoform d
NM_012198.5 NP_036330.1 grancalcin isoform b
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
11717497 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
12804766 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
11717497 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCA Protein Structure

EF-hand_8

EF-hand_8: EF-hand domain pair (64 - 119)

EF-hand_6

EF-hand_6: EF-hand domain (125 - 150)

  • 0
  • 100
  • 200
  • 217 a.a.
Protein Preferred Names Protein Names

grancalcin

grancalcin, EF-hand calcium-binding protein

GCA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GCA P28676 MAGEA8 Homo sapiens P43361
Validated Y2H
32296183
Intra
GCA P28676 MAGEA8 Homo sapiens P43361
Y2H Array
31515488
Intra
GCA P28676 MAGEA8 Homo sapiens P43361
Y2H Prey Pooling
32296183
Intra
GCA P28676 MAGEA8 Homo sapiens P43361
Y2H Array
32296183
Intra
GCA P28676 MAGEA8 Homo sapiens P43361
Y2H Array
25416956
Intra
GCA P28676 MAGEA8 Homo sapiens P43361
Y2H Array
29892012
Intra
GCA P28676 MAGEA8 Homo sapiens P43361
Validated Y2H
25416956
Intra
GCA P28676 GSTO2 Homo sapiens Q9H4Y5
Y2H Array
32296183
Intra
GCA P28676 GSTO2 Homo sapiens Q9H4Y5
Validated Y2H
32296183
Intra
GCA P28676 GSTO2 Homo sapiens Q9H4Y5
Y2H Prey Pooling
32296183
Intra
GCA P28676 ABHD11 Homo sapiens Q8NFV4-4
Validated Y2H
32296183
Intra
GCA P28676 ABHD11 Homo sapiens Q8NFV4-4
Y2H Array
32296183
Intra
GCA P28676 ABHD11 Homo sapiens Q8NFV4-4
Y2H Prey Pooling
32296183
Intra
GCA P28676 C10orf55 Homo sapiens Q5SWW7
Y2H Prey Pooling
32296183
Intra
GCA P28676 C10orf55 Homo sapiens Q5SWW7
Validated Y2H
32296183
Intra
GCA P28676 C10orf55 Homo sapiens Q5SWW7
Y2H Array
32296183
Intra
GCA P28676 CSTPP1 Homo sapiens Q9H6J7-2
Validated Y2H
32296183
Intra
GCA P28676 CSTPP1 Homo sapiens Q9H6J7-2
Y2H Array
32296183
Intra
GCA P28676 CSTPP1 Homo sapiens Q9H6J7-2
Y2H Prey Pooling
32296183
Intra
GCA P28676 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
GCA P28676 TRAF2 Homo sapiens Q12933
Validated Y2H
32296183
Intra
GCA P28676 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
GCA P28676 TRAF1 Homo sapiens Q13077
Y2H Prey Pooling
32296183
Intra
GCA P28676 TRAF1 Homo sapiens Q13077
Validated Y2H
32296183
Intra
GCA P28676 TRAF1 Homo sapiens Q13077
Y2H Array
32296183
Intra
GCA P28676 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
GCA P28676 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
GCA P28676 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
GCA P28676 PSMB4 Homo sapiens P28070
Y2H Array
32296183
Intra
GCA P28676 CALCOCO2 Homo sapiens Q13137
Validated Y2H
32296183
Intra
GCA P28676 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
GCA P28676 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
GCA P28676 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
GCA P28676 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Intra
GCA P28676 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
GCA P28676 ATXN1 Homo sapiens P54253
Y2H
16713569
Intra
GCA P28676 BPIFA1 Homo sapiens Q9NP55
Validated Y2H
32296183
Intra
GCA P28676 BPIFA1 Homo sapiens Q9NP55
Y2H Array
32296183
Intra
GCA P28676 BPIFA1 Homo sapiens Q9NP55
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GCA Proteins

Cat. No. Product Name Accession Purity
HY-P70334 Grancalcin/GCA Protein, Human (His) P28676 (M1-I217) ≥95%
HY-P72635 Grancalcin/GCA Protein, Human (GST) P28676 (M1-I217) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-143230 Custirsen / Phase 3
HY-142118 Trabedersen Inhibitor 90.45% Phase 3
HY-145721 Mongersen Inhibitor / Phase 3
HY-132596 Tivanisiran Inhibitor / Phase 3
HY-145728 Alicaforsen Inhibitor / Phase 3
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100540 Golgicide A Inhibitor 99.85% Unkown
HY-100540B Golgicide A-2 Inhibitor 99.53% Unkown
HY-100540C Golgicide A-1 Control 99.94% Unkown
HY-149453 MCUF-651 Modulator 99.85% Unkown
HY-100540A (Rac)-Golgicide A Inhibitor / Unkown
HY-116528 GCA-186 Inhibitor / Unkown
HY-150213 ODN BW001 Inhibitor / Unkown
HY-RS05317 GCA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GCA MGD MGI:1918521
Macaca mulatta GCA VGNC VGNC:72726
Canis familiaris GCA VGNC VGNC:41137
Rattus norvegicus GCA RGD RGD:1306589
Felis catus GCA VGNC VGNC:80217
Bos taurus GCA VGNC VGNC:29278
Others GCA NCBI