PSMB4 - proteasome 20S subunit beta 4 Gene

Homo sapiens

Also known as HN3; HsN3; PRAAS3; PROS26; PROS-26

Gene ID: 5692 | Gene type: protein coding

About PSMB4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,399,573-151,401,937 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in placenta (RPKM 102.8), lymph node (RPKM 94.8) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the Proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. [provided by RefSeq, Jul 2008]

PSMB4 Products(1)

mRNA	Protein	Name
NM_002796.3	NP_002787.2	proteasome subunit beta type-4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15231748	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	29257953	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMB4 Protein Structure

Proteasome

0
100
200
264 a.a.

Protein Preferred Names

Protein Names

proteasome subunit beta type-4

26 kDa prosomal protein

PSMB4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PSMB4	P28070	P4HA3	Homo sapiens	Q7Z4N8	Validated Y2H	32296183
Intra	PSMB4	P28070	TEKT5	Homo sapiens	Q96M29	Validated Y2H	32296183
Intra	PSMB4	P28070	HEMK1	Homo sapiens	Q9Y5R4	Validated Y2H	32296183
Intra	PSMB4	P28070	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Prey Pooling	32296183
Intra	PSMB4	P28070	KRTAP19-5	Homo sapiens	Q3LI72	Validated Y2H	32296183
Intra	PSMB4	P28070	KRTAP19-5	Homo sapiens	Q3LI72	Y2H Array	32296183
Intra	PSMB4	P28070	CCDC57	Homo sapiens	Q2TAC2-2	Validated Y2H	32296183
Intra	PSMB4	P28070	TLE5	Homo sapiens	Q08117-2	Validated Y2H	32296183
Intra	PSMB4	P28070	TFAP2D	Homo sapiens	Q7Z6R9	Validated Y2H	32296183
Intra	PSMB4	P28070	SYNPO2L	Homo sapiens	Q9H987-2	Validated Y2H	32296183
Intra	PSMB4	P28070	PITX2	Homo sapiens	Q99697-2	Validated Y2H	32296183
Intra	PSMB4	P28070	SOHLH1	Homo sapiens	Q5JUK2	Validated Y2H	32296183
Intra	PSMB4	P28070	SMAD1	Homo sapiens	Q15797	Validated Y2H	32296183
Intra	PSMB4	P28070	KANK2	Homo sapiens	Q63ZY3	Validated Y2H	32296183
Intra	PSMB4	P28070	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	PSMB4	P28070	PSMA3	Homo sapiens	P25788	Anti Tag CoIP	33961781
Intra	PSMB4	P28070	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	25416956
Intra	PSMB4	P28070	PFDN5	Homo sapiens	Q99471	Validated Y2H	32296183
Intra	PSMB4	P28070	PFDN5	Homo sapiens	Q99471	Y2H Prey Pooling	32296183
Intra	PSMB4	P28070	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	33961781
Intra	PSMB4	P28070	PSMB5	Homo sapiens	P28074	Anti Tag CoIP	28514442
Intra	PSMB4	P28070	PSMB5	Homo sapiens	P28074	Y2H	17948026
Intra	PSMB4	P28070	PSMB1	Homo sapiens	P20618	Anti Tag CoIP	35271311
Intra	PSMB4	P28070	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	PSMB4	P28070	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	PSMB4	P28070	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	PSMB4	P28070	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	PSMB4	P28070	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	PSMB4	P28070	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	PSMB4	P28070	MYOZ3	Homo sapiens	Q8TDC0	Validated Y2H	32296183
Intra	PSMB4	P28070	PKN1	Homo sapiens	Q16512	Validated Y2H	32296183
Intra	PSMB4	P28070	PSMB7	Homo sapiens	Q99436	Anti Tag CoIP	33961781
Intra	PSMB4	P28070	PSMB7	Homo sapiens	Q99436	Anti Tag CoIP	28514442
Intra	PSMB4	P28070	PSMB7	Homo sapiens	Q99436	Y2H	17948026
Intra	PSMB4	P28070	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	33961781
Intra	PSMB4	P28070	POMP	Homo sapiens	Q9Y244	Anti Tag CoIP	28514442
Intra	PSMB4	P28070	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	PSMB4	P28070	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	PSMB4	P28070	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
Intra	PSMB4	P28070	GABARAPL1	Homo sapiens	Q9H0R8	Validated Y2H	32296183
Intra	PSMB4	P28070	BCL6	Homo sapiens	P41182	Validated Y2H	32296183
Intra	PSMB4	P28070	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183
Intra	PSMB4	P28070	ATXN1	Homo sapiens	P54253	Validated Y2H	32814053
Intra	PSMB4	P28070	ATXN1	Homo sapiens	P54253	Y2H Pooling	32814053
Intra	PSMB4	P28070	ATXN1	Homo sapiens	P54253	Y2H Array	32814053
Intra	PSMB4	P28070	GCA	Homo sapiens	P28676	Y2H Prey Pooling	32296183
Intra	PSMB4	P28070	GCA	Homo sapiens	P28676	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Proteasome-Associated Autoinflammatory Syndrome 3

Proteasome-Associated Autoinflammatory Syndrome 3, Digenic	PRAAS3
Proteasome-Associated Autoinflammatory Syndrome 3 And Digenic Forms

Proteasome-Associated Autoinflammatory Syndrome 1

Jmp Syndrome	Nakajo-Nishimura Syndrome
Nkjo	Autoinflammation, Lipodystrophy, And Dermatosis Syndrome
Proteasome-Associated Autoinflammatory Syndrome 1 And Digenic Forms	Nakajo Syndrome
PRAAS1	Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy And Elevated Temperature Syndrome
Candle	Joint Contractures, Muscular Atrophy, Microcytic Anemia, And Panniculitis-Induced Lipodystrophy
Aldd	Inflammation
Joint Contractures - Muscle Atrophy - Microcytic Anemia - Panniculitis-Induced Lipodystrophy	Nakajo Nishimura Syndrome
Amyotrophy Fat Tissue Anomaly	Japanese Autoinflammatory Syndrome With Lipodystrophy
Jasl	Joint Contractures Muscular Atrophy Microcytic Anemia And Panniculitis-Induced Lipodystrophy
Nns	Nodular Erythema With Digital Changes
Secondary Hypertrophic Osteoperiostosis With Pernio

Nakajo Syndrome

Nodular Erythema Digital Changes

Panniculitis

Nodular Panniculitis

Proteasome-Associated Autoinflammatory Syndrome

Aldd Syndrome	Autoinflammation-Lipodystrophy-Dermatosis Syndrome
Praas	Proteasome Disability Syndrome

Atrophoderma Vermiculata

Atrophoderma Vermiculatum	Folliculitis Ulerythematosa Reticulata
Atrophodermia Vermiculata	Honeycomb Atrophy
Atrophodermia Reticulata Symmetrica Faciei	AVA
Atrophodermia Reticulata	Folliculitis Ulerythematosa
Folliculitis Ulerythematosa Reticulate	Burnett Schwartz Berberian Syndrome

Nodular Episcleritis

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Basal Ganglia Calcification

Fahr'S Syndrome	Fahr'S Disease
Fahr Disease

Basal Ganglia Disease

Basal Ganglia Diseases	Basal Ganglia Disorders
Abnormality Of The Basal Ganglia

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11304	PSMB4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PSMB4	VGNC	VGNC:76444
Rattus norvegicus	PSMB4	RGD	RGD:61877
Canis familiaris	PSMB4	VGNC	VGNC:45096
Bos taurus	PSMB4	VGNC	VGNC:33448
Felis catus	PSMB4	VGNC	VGNC:69110
Mus musculus	PSMB4	MGD	MGI:1098257

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