BRMS1 - BRMS1 transcriptional repressor and anoikis regulator Gene

Homo sapiens

Gene ID: 25855 | Gene type: protein coding

About BRMS1

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,337,339-66,345,104 (from NCBI)

This gene has 9 transcripts (splice variants), 178 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues.

Summary

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast Cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

BRMS1 Products(2)

mRNA	Protein	Name
NM_001024957.2	NP_001020128.1	breast cancer metastasis-suppressor 1 isoform 2
NM_015399.4	NP_056214.1	breast cancer metastasis-suppressor 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IDA IDA: Inferred from direct assay	17000776	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16919237	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20830743	GOA
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	17000776	GOA
involved in positive regulation of anoikis	IMP IMP: Inferred from mutant phenotype	17000776	GOA
involved in positive regulation of protein deacetylation	IDA IDA: Inferred from direct assay	17000776	GOA
involved in regulation of apoptotic process	IDA IDA: Inferred from direct assay	17000776	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20830743	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17000776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRMS1 Protein Structure

Sds3

0
100
200
246 a.a.

Protein Preferred Names

Protein Names

breast cancer metastasis-suppressor 1

breast cancer metastasis suppressor 1

BRMS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BRMS1	Q9HCU9	DNAJB6	Homo sapiens	O75190	Anti Bait CoIP	16919237
Intra	BRMS1	Q9HCU9	DNAJB6	Homo sapiens	O75190	Y2H	16919237
Intra	BRMS1	Q9HCU9	HDAC6	Homo sapiens	Q9UBN7	Anti Bait CoIP	16919237
Intra	BRMS1	Q9HCU9	HDAC6	Homo sapiens	Q9UBN7	Anti Tag CoIP	16919237
Intra	BRMS1	Q9HCU9	HDAC2	Homo sapiens	Q92769	Anti Bait CoIP	16919237
Intra	BRMS1	Q9HCU9	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	33961781
Intra	BRMS1	Q9HCU9	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	28514442
Intra	BRMS1	Q9HCU9	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	16919237
Intra	BRMS1	Q9HCU9	HDAC4	Homo sapiens	P56524	Anti Bait CoIP	16919237
Intra	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Validated Y2H	25416956
Intra	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Anti Bait CoIP	16919237
Intra	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Y2H	16919237
Intra	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	Y2H Prey Pooling	25416956
Intra	BRMS1	Q9HCU9	NMI	Homo sapiens	Q13287	MAPPIT	25416956
Intra	BRMS1	Q9HCU9	SMARCE1	Homo sapiens	Q969G3	Anti Bait CoIP	16919237
Intra	BRMS1	Q9HCU9	SMARCE1	Homo sapiens	Q969G3	Anti Tag CoIP	25416956
Intra	BRMS1	Q9HCU9	SUDS3	Homo sapiens	Q9H7L9	Y2H	16919237
Intra	BRMS1	Q9HCU9	SUDS3	Homo sapiens	Q9H7L9	Anti Bait CoIP	16919237
Intra	BRMS1	Q9HCU9	HDAC5	Homo sapiens	Q9UQL6	Anti Tag CoIP	16919237
Intra	BRMS1	Q9HCU9	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145946	BRM/BRG1 ATP Inhibitor-2	Inhibitor	99.67%	Unkown
HY-148373	BRM/BRG1 ATP Inhibitor-3	Inhibitor	/	Unkown
HY-148374	BRM/BRG1 ATP Inhibitor-4	Inhibitor	/	Unkown
HY-RS01626	BRMS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	BRMS1	VGNC	VGNC:60178
Canis familiaris	BRMS1	VGNC	VGNC:54777
Bos taurus	BRMS1	VGNC	VGNC:54781
Rattus norvegicus	BRMS1	RGD	RGD:1311057
Mus musculus	BRMS1	MGD	MGI:2388804
Macaca mulatta	BRMS1	VGNC	VGNC:70334

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