HDAC5 - histone deacetylase 5 Gene

Homo sapiens

Also known as HD5; NY-CO-9

Gene ID: 10014 | Gene type: protein coding

About HDAC5

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:44,076,753-44,123,641 (from NCBI)

This gene has 13 transcripts (splice variants), 194 orthologues and 10 paralogues. Ubiquitous expression in skin (RPKM 14.0), ovary (RPKM 13.4) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon Cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HDAC5 Products(16)

mRNA	Protein	Name
XM_047435054.1	XP_047291010.1	histone deacetylase 5 isoform X7
NM_001382393.1	NP_001369322.1	histone deacetylase 5 isoform 1
XM_047435048.1	XP_047291004.1	histone deacetylase 5 isoform X2
NM_139205.1
XM_047435051.1	XP_047291007.1	histone deacetylase 5 isoform X3
NM_005474.5	NP_005465.2	histone deacetylase 5 isoform 1
XM_047435055.1	XP_047291011.1	histone deacetylase 5 isoform X8
XM_011524149.3	XP_011522451.1	histone deacetylase 5 isoform X4
XM_047435053.1	XP_047291009.1	histone deacetylase 5 isoform X6
NM_001015053.2	NP_001015053.1	histone deacetylase 5 isoform 3
XM_047435052.1	XP_047291008.1	histone deacetylase 5 isoform X5
XM_047435050.1	XP_047291006.1	histone deacetylase 5 isoform X3
XM_047435049.1	XP_047291005.1	histone deacetylase 5 isoform X2
XM_047435047.1	XP_047291003.1	histone deacetylase 5 isoform X1
XM_047435056.1	XP_047291012.1	histone deacetylase 5 isoform X8
XM_047435057.1	XP_047291013.1	histone deacetylase 5 isoform X9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	12242305	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24413532	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	19071119	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10869435	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	23867755	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables protein kinase C binding	IPI IPI: Inferred from physical interaction	20188095	GOA
enables protein lysine deacetylase activity	IMP IMP: Inferred from mutant phenotype	23867755	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	19351956	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	10898795	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell migration involved in sprouting angiogenesis	IMP IMP: Inferred from mutant phenotype	19351956	GOA
involved in negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	10983972	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16236793	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10869435	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10983972	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in regulation of protein binding	IMP IMP: Inferred from mutant phenotype	19071119	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10869435	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10869435	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC5 Protein Structure

HDAC4_Gln

Hist_deacetyl

0
200
400
600
800
1000
1122 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 5

antigen NY-CO-9

HDAC5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HDAC5	Q9UQL6	LMO2	Homo sapiens	P25791-3	Y2H Array	32296183
Intra	HDAC5	Q9UQL6	LMO2	Homo sapiens	P25791-3	Y2H Prey Pooling	32296183
Intra	HDAC5	Q9UQL6	MEF2C	Homo sapiens	Q06413	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	HDAC5	Q9UQL6	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	SFN	Homo sapiens	P31947	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	BRMS1	Homo sapiens	Q9HCU9	Anti Bait CoIP	16919237
Intra	HDAC5	Q9UQL6	YWHAE	Homo sapiens	P62258	CoIP	10737771
Intra	HDAC5	Q9UQL6	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	23752268
Intra	HDAC5	Q9UQL6	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	23752268
Cross	HDAC5	Q9UQL6	Grk5	Mus musculus	Q8VEB1	Protein Kinase Assay	18711143
Cross	HDAC5	Q9UQL6	Grk5	Mus musculus	Q8VEB1	Anti Tag CoIP	18711143
Cross	HDAC5	Q9UQL6	ICP0	Human herpesvirus 1	P08393	Pull Down	15194749
Cross	HDAC5	Q9UQL6	ICP0	Human herpesvirus 1	P08393	CoIP	15194749

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Alzheimer Disease 19

AD19	Alzheimer'S Disease 19
Alzheimer Disease 19, Late-Onset	Alzheimer Disease 19 Late Onset
Late-Onset Alzheimer Disease	Alzheimer Disease, Late Onset, Susceptibility To, Type 19
Alzheimer Disease, Late Onset

Anhidrosis, Isolated, With Normal Sweat Glands

Isolated Anhidrosis With Normal Sweat Glands	Dann-Epstein-Sohar Syndrome
ANHD	Isolated Generalized Anhidrosis With Normal Sweat Glands
Anhidrosis, Familial Generalized, With Normal Sweat Glands

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Rett Syndrome

Atypical Rett Syndrome	RTT
Rts	Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use
Rett Syndrome, Atypical	Rett Syndrome, Preserved Speech Variant
Rett'S Disorder	Rett Syndrome Variant
Rett Disorder	Cerebroatrophic Hyperammonemia
Rett Like Syndrome	Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome
Rett'S Syndrome	Atypical Rtt
Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use	Rett Syndrome Preserved Speech Variant
Rett Syndrome Zappella Variant	Rett Syndrome, Zappella Variant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.81%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.05%	Phase 1

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-115475	SW-100	Inhibitor	99.93%	Unkown
HY-112719	BRD 4354	Inhibitor	99.66%	Unkown
HY-143248	KR-39038	Inhibitor	99.48%	Unkown
HY-126330	SS-208	Inhibitor	99.00%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-112719B	BRD 4354 ditrifluoroacetate	Inhibitor	98.06%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-124946	C1A	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-146351	HDAC-IN-38	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-148624	CHDI-00484077	Inhibitor	/	Unkown
HY-135714	Bavarostat	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	HDAC5	VGNC	VGNC:49093
Macaca mulatta	HDAC5	VGNC	VGNC:73166
Felis catus	HDAC5	VGNC	VGNC:62768
Mus musculus	HDAC5	MGD	MGI:1333784
Rattus norvegicus	HDAC5	RGD	RGD:619980
Bos taurus	HDAC5	VGNC	VGNC:50612

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