HDAC4 - histone deacetylase 4 Gene

Homo sapiens

Also known as HD4; AHO3; BDMR; HDACA; HA6116; HDAC-4; HDAC-A; NEDCHF; NEDCHID

Gene ID: 9759 | Gene type: protein coding

About HDAC4

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:239,048,168-239,401,649 (from NCBI)

This gene has 18 transcripts (splice variants), 263 orthologues, 10 paralogues and is associated with 5 phenotypes. Ubiquitous expression in brain (RPKM 2.4), testis (RPKM 1.6) and 24 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

HDAC4 Products(42)

mRNA	Protein	Name
XM_006712877.4	XP_006712940.1	histone deacetylase 4 isoform X2
XM_047446498.1	XP_047302454.1	histone deacetylase 4 isoform X29
XM_047446487.1	XP_047302443.1	histone deacetylase 4 isoform X18
XM_047446493.1	XP_047302449.1	histone deacetylase 4 isoform X24
XM_047446497.1	XP_047302453.1	histone deacetylase 4 isoform X28
XM_011512224.3	XP_011510526.1	histone deacetylase 4 isoform X11
XM_011512225.3	XP_011510527.1	histone deacetylase 4 isoform X13
XM_047446495.1	XP_047302451.1	histone deacetylase 4 isoform X26
XM_047446486.1	XP_047302442.1	histone deacetylase 4 isoform X17
XM_047446489.1	XP_047302445.1	histone deacetylase 4 isoform X20
XM_047446478.1	XP_047302434.1	histone deacetylase 4 isoform X8
XM_047446484.1	XP_047302440.1	histone deacetylase 4 isoform X14
XM_011512218.3	XP_011510520.1	histone deacetylase 4 isoform X3
XM_024453257.2	XP_024309025.1	histone deacetylase 4 isoform X19
XM_011512219.3	XP_011510521.1	histone deacetylase 4 isoform X4
XM_006712880.4	XP_006712943.1	histone deacetylase 4 isoform X19
XM_011512227.3	XP_011510529.1	histone deacetylase 4 isoform X23
XM_011512222.4	XP_011510524.1	histone deacetylase 4 isoform X6
XM_047446488.1	XP_047302444.1	histone deacetylase 4 isoform X19
XM_047446496.1	XP_047302452.1	histone deacetylase 4 isoform X27
XM_011512223.3	XP_011510525.1	histone deacetylase 4 isoform X6
XM_047446482.1	XP_047302438.1	histone deacetylase 4 isoform X14
NM_001378417.1	NP_001365346.1	histone deacetylase 4 isoform 2
XM_047446483.1	XP_047302439.1	histone deacetylase 4 isoform X14
NM_001378416.1	NP_001365345.1	histone deacetylase 4 isoform 2
XM_047446485.1	XP_047302441.1	histone deacetylase 4 isoform X15
XM_047446491.1	XP_047302447.1	histone deacetylase 4 isoform X21
NM_006037.4	NP_006028.2	histone deacetylase 4 isoform 2
XM_011512226.3	XP_011510528.1	histone deacetylase 4 isoform X17
XM_011512217.3	XP_011510519.1	histone deacetylase 4 isoform X1
XM_047446477.1	XP_047302433.1	histone deacetylase 4 isoform X7
XM_011512220.3	XP_011510522.1	histone deacetylase 4 isoform X5
XM_047446490.1	XP_047302446.1	histone deacetylase 4 isoform X20
XM_047446479.1	XP_047302435.1	histone deacetylase 4 isoform X9
XM_047446492.1	XP_047302448.1	histone deacetylase 4 isoform X22
XM_047446480.1	XP_047302436.1	histone deacetylase 4 isoform X10
XM_047446494.1	XP_047302450.1	histone deacetylase 4 isoform X25
XM_017005394.2	XP_016860883.1	histone deacetylase 4 isoform X16
NM_001378414.1	NP_001365343.1	histone deacetylase 4 isoform 1
NM_001378415.1	NP_001365344.1	histone deacetylase 4 isoform 1
XM_047446476.1	XP_047302432.1	histone deacetylase 4 isoform X6
XM_047446481.1	XP_047302437.1	histone deacetylase 4 isoform X12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	10983972	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24413532	GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	18850004	GOA
enables SUMO transferase activity	EXP EXP: Inferred from Experiment	17218271	GOA
contributes to histone binding	IDA IDA: Inferred from direct assay	19276356	GOA
enables histone deacetylase activity	IDA IDA: Inferred from direct assay	10220385	GOA
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17360518	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	31127039	GOA
enables potassium ion binding	IDA IDA: Inferred from direct assay	18614528	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10869435	GOA
enables protein lysine deacetylase activity	IDA IDA: Inferred from direct assay	18614528	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	18850004	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	18614528	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	18850004	GOA
involved in negative regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in negative regulation of gene expression, epigenetic	IDA IDA: Inferred from direct assay	10869435	GOA
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in negative regulation of myotube differentiation	IMP IMP: Inferred from mutant phenotype	10983972	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16236793	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10869435	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	15743821	GOA
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	19276356	GOA
involved in peptidyl-lysine deacetylation	IDA IDA: Inferred from direct assay	18614528	GOA
involved in positive regulation of DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	18850004	GOA
involved in positive regulation of protein sumoylation	IDA IDA: Inferred from direct assay	17696781	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in protein deacetylation	IDA IDA: Inferred from direct assay	27708256	GOA
involved in regulation of protein binding	IMP IMP: Inferred from mutant phenotype	19071119	GOA
involved in response to interleukin-1	IMP IMP: Inferred from mutant phenotype	19281832	GOA
involved in type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	31127039	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	31127039	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10869435	GOA
part of histone deacetylase complex	IDA IDA: Inferred from direct assay	11804585	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10869435	GOA
part of transcription repressor complex	IDA IDA: Inferred from direct assay	11804585	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC4 Protein Structure

HDAC4_Gln

Hist_deacetyl

Arb2

0
200
400
600
800
1000
1084 a.a.

Protein Preferred Names

Protein Names

histone deacetylase 4

histone deacetylase A

HDAC4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HDAC4	P56524	KRT38	Homo sapiens	O76015	Validated Y2H	25416956
Intra	HDAC4	P56524	KRT38	Homo sapiens	O76015	Y2H Array	25416956
Intra	HDAC4	P56524	ATF2	Homo sapiens	P15336	Anti Bait CoIP	20116378
Intra	HDAC4	P56524	CDR2	Homo sapiens	Q01850	Y2H Array	25416956
Intra	HDAC4	P56524	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	HDAC4	P56524	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	HDAC4	P56524	YWHAH	Homo sapiens	Q04917	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	CoIP	15324660
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Pull Down	11504882
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Validated Y2H	25416956
Intra	HDAC4	P56524	YWHAG	Homo sapiens	P61981	Anti Tag CoIP	17159145
Intra	HDAC4	P56524	YWHAZ	Homo sapiens	P63104	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	Y2H Pooling	20936779
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	CoIP	18045992
Intra	HDAC4	P56524	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAB	Homo sapiens	P31946	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	YWHAB	Homo sapiens	P31946	CoIP	10958686
Intra	HDAC4	P56524	YWHAQ	Homo sapiens	P27348	CoIP	18045992
Intra	HDAC4	P56524	YWHAQ	Homo sapiens	P27348	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	MIF4GD	Homo sapiens	A9UHW6	Pull Down	21988832
Intra	HDAC4	P56524	MIF4GD	Homo sapiens	A9UHW6	Confocal	21988832
Intra	HDAC4	P56524	SFN	Homo sapiens	P31947	Y2H	16767219
Intra	HDAC4	P56524	SFN	Homo sapiens	P31947	TAP	15778465
Intra	HDAC4	P56524	SFN	Homo sapiens	P31947	Anti Tag CoIP	23752268
Intra	HDAC4	P56524	AR	Homo sapiens	P10275	Anti Bait CoIP	21242980
Intra	HDAC4	P56524	AR	Homo sapiens	P10275	Pull Down	21242980
Intra	HDAC4	P56524	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	HDAC4	P56524	BRMS1	Homo sapiens	Q9HCU9	Anti Tag CoIP	16919237
Intra	HDAC4	P56524	RINT1	Homo sapiens	Q6NUQ1	Validated Y2H	25416956
Intra	HDAC4	P56524	EFEMP2	Homo sapiens	O95967	Y2H Prey Pooling	25416956
Intra	HDAC4	P56524	EFEMP2	Homo sapiens	O95967	Validated Y2H	25416956
Intra	HDAC4	P56524	EFEMP2	Homo sapiens	O95967	Y2H Array	25416956
Cross	HDAC4	P56524	EBNA-LP	Epstein-Barr virus	Q8AZK7	Pull Down	17159145
Cross	HDAC4	P56524	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Tag CoIP	17159145
Cross	HDAC4	P56524	EBNA-LP	Epstein-Barr virus	Q8AZK7	Anti Bait CoIP	17159145
Cross	HDAC4	P56524	ICP0	Human herpesvirus 1	P08393	Pull Down	15194749
Cross	HDAC4	P56524	ICP0	Human herpesvirus 1	P08393	CoIP	15194749

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Muscle Hypertrophy

MSLHP	Hypertrophy, Muscle
Hypertrophy

Mature T-Cell And Nk-Cell Lymphoma

Mature T-Cell And Natural Killer Cell Lymphoma

Nk-T Cell Lymphoma

Neurodevelopmental Disorder With Central Hypotonia And Dysmorphic Facies

NEDCHF

Acrodysostosis

Acrodysplasia	Arkless-Graham Syndrome
Maroteaux-Malamut Syndrome	Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome
Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Desmoplastic/Nodular Medulloblastoma	Medulloblastoma With Extensive Nodularity
Desmoplastic Medulloblastoma	Medulloblastoma, Somatic
Medulloblastoma, Desmoplastic	Brain Medulloblastoma
Cns Pnet	Infratentorial Primitive Neuroectodermal Tumor
Mben	Medulloblastoma Desmoplastic
Neuroectodermal Tumors, Primitive	Medulloblastomas
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Myeloma, Multiple

Multiple Myeloma	Kahler Disease
Myelomatosis	Plasma Cell Myeloma
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Multiple Myeloma, Susceptibility To	Myeloma - Multiple
Kahler'S Disease	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Brachydactyly

Chromosome 2q37 Deletion Syndrome

Albright Hereditary Osteodystrophy-Like Syndrome	2q37 Microdeletion Syndrome
Brachydactyly-Intellectual Disability Syndrome	Deletion 2q37
2q37 Deletion Syndrome	Brachydactyly-Mental Retardation Syndrome
Bdmr	Albright Hereditary Osteodystrophy Type 3
Del(2)(Q37)	Monosomy 2q37qter
Albright'S Hereditary Osteodystrophy-Like Syndrome	Monosomy 2q37
Chromosome Deletion Syndrome 2q37

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Plasma Cell Neoplasm

Plasma Cell Dyscrasia	Paraproteinemias
Plasma Cell Tumour	Plasmacytic Tumor
Multiple Myeloma	Plasmacytoma
Plasma Cell Tumours	Plasma Cells Dyscrasia

Pseudohypoparathyroidism, Type Ia

Albright'S Hereditary Osteodystrophy	Albright Hereditary Osteodystrophy
Pseudohypoparathyroidism Type 1a	PHP1A
Albright Hereditary Osteodystrophy With Multiple Hormone Resistance	Pseudohypoparathyroidism Ia
AHO	Pseudohypoparathyroidism With Albright Hereditary Osteodystrophy
Pseudo-Pseudohypoparathyroidism	Pseudohypoparathyroidism Type I A
Php Ia	Pseudopseudohypoparathyroidism
Albright Hereditary Osteodystrophy Without Multiple Hormone Resistance	Pphp
Pseudopseudo-Hypoparathyroidism	Aho-Php Syndrome Ia
Albright Hereditary Osteodystrophy-Php Syndrome Ia	Pseudohypoparathyroidism 1a
Pseudohypoparathyroidism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15149	Romidepsin	Inhibitor	99.98%	Unkown
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-14842	Givinostat	Inhibitor	98.16%	Yes

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10528	Tasquinimod	Modulator	99.94%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	98.06%	Phase 3
HY-16026	Ricolinostat	Inhibitor	99.83%	Phase 2
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.28%	Phase 2
HY-10223	CUDC-101	Inhibitor	98.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-18361	TMP195	Inhibitor	99.57%	Unkown
HY-18998	LMK-235	Inhibitor	99.61%	Unkown
HY-13428	Tubacin	Inhibitor	99.54%	Unkown
HY-18360	TMP269	Inhibitor	98.05%	Unkown
HY-16699	Nexturastat A	Inhibitor	98.28%	Unkown
HY-119939	CHDI-390576	Inhibitor	98.07%	Unkown
HY-115475	SW-100	Inhibitor	99.59%	Unkown
HY-19350	BML-210	Inhibitor	98.06%	Unkown
HY-123295	HDAC3-IN-T247	Inhibitor	98.94%	Unkown
HY-12954	PTACH	Inhibitor	99.65%	Unkown
HY-149285	NT160	Inhibitor	99.58%	Unkown
HY-146153	HDAC-IN-40	Inhibitor	98.71%	Unkown
HY-117554	BRD9757	Inhibitor	99.75%	Unkown
HY-146678	HDAC6-IN-5	Inhibitor	/	Unkown
HY-146679	HDAC6-IN-6	Inhibitor	/	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-149208	HDAC-IN-53	Inhibitor	/	Unkown
HY-149372	HDAC6-IN-17	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-163803	CM-444	Inhibitor	/	Unkown
HY-150503	KH-259	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-146159	PI3K/HDAC-IN-2	Inhibitor	/	Unkown
HY-151897	HDAC-IN-49	Inhibitor	/	Unkown
HY-143233	PIM-1/HDAC-IN-1	Inhibitor	/	Unkown
HY-149721	HDAC4-IN-1	Inhibitor	/	Unkown
HY-163143	HDAC8-IN-6	Inhibitor	/	Unkown
HY-162630	HDAC6-IN-44	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-151263	G4/HDAC-IN-1	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown
HY-147934	HDAC8-IN-3	Inhibitor	/	Unkown
HY-161778	ZG-126	Inhibitor	/	Unkown
HY-151896	HDAC6-IN-14	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HDAC4	RGD	RGD:619979
Macaca mulatta	HDAC4	VGNC	VGNC:82155
Felis catus	HDAC4	VGNC	VGNC:62767
Mus musculus	HDAC4	MGD	MGI:3036234
Canis familiaris	HDAC4	VGNC	VGNC:50629
Bos taurus	HDAC4	VGNC	VGNC:50611

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