CNOT10 - CCR4-NOT transcription complex subunit 10 Gene

Homo sapiens

Gene ID: 25904 | Gene type: protein coding

About CNOT10

This gene has 18 transcripts (splice variants) and 209 orthologues. Broad expression in testis (RPKM 18.8), thyroid (RPKM 7.6) and 24 other tissues.

Summary

Predicted to be involved in mRNA catabolic process and negative regulation of translation. Located in membrane. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

CNOT10 Products(7)

mRNA	Protein	Name
NM_001256741.2	NP_001243670.1	CCR4-NOT transcription complex subunit 10 isoform 2
NM_001256742.2	NP_001243671.1	CCR4-NOT transcription complex subunit 10 isoform 3
NM_001393366.1	NP_001380295.1	CCR4-NOT transcription complex subunit 10 isoform 4
NM_001393367.1	NP_001380296.1	CCR4-NOT transcription complex subunit 10 isoform 5
NM_001393368.1	NP_001380297.1	CCR4-NOT transcription complex subunit 10 isoform 6
NM_001393369.1	NP_001380298.1	CCR4-NOT transcription complex subunit 10 isoform 7
NM_015442.3	NP_056257.1	CCR4-NOT transcription complex subunit 10 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17452450	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	19558367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CNOT10 Protein Structure

TPR_1

0
200
400
600
744 a.a.

Protein Preferred Names

Protein Names

CCR4-NOT transcription complex subunit 10

CNOT10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CNOT10	Q9H9A5	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	33961781
Intra	CNOT10	Q9H9A5	CNOT6L	Homo sapiens	Q96LI5	Anti Tag CoIP	17452450
Intra	CNOT10	Q9H9A5	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	33961781
Intra	CNOT10	Q9H9A5	CNOT11	Homo sapiens	Q9UKZ1	Y2H	23232451
Intra	CNOT10	Q9H9A5	CNOT11	Homo sapiens	Q9UKZ1	Anti Tag CoIP	33961781
Intra	CNOT10	Q9H9A5	CNOT11	Homo sapiens	Q9UKZ1	Pull Down	23232451
Intra	CNOT10	Q9H9A5	TOB1	Homo sapiens	P50616	TAP	18377426

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Mayer-Rokitansky-Kuster-Hauser Syndrome Type 1

Rokitansky Sequence	Congenital Absence Of Uterus And Vagina
Mrkh Syndrome Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02900	CNOT10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CNOT10	VGNC	VGNC:27515
Canis familiaris	CNOT10	VGNC	VGNC:39411
Rattus norvegicus	CNOT10	RGD	RGD:1359219
Mus musculus	CNOT10	MGD	MGI:1926143
Felis catus	CNOT10	VGNC	VGNC:61026
Macaca mulatta	CNOT10	VGNC	VGNC:71327

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