1. Gene
  2. Axl - AXL receptor tyrosine kinase Gene

Axl - AXL receptor tyrosine kinase Gene

Mus musculus

Also known as Ark; Ufo; Tyro7

Gene ID: 26362 | Gene type: protein coding

About Axl

Summary

Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; myeloid cell homeostasis; and negative regulation of tumor necrosis factor production. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human Axl (Axl receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Axl Products(3)

mRNA Protein Name
NM_001190974.1 NP_001177903.1 tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_001190975.1 NP_001177904.1 tyrosine-protein kinase receptor UFO isoform 3 precursor
NM_009465.4 NP_033491.2 tyrosine-protein kinase receptor UFO isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18787040 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
17442946 MGI
involved in apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
18159085 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: Inferred from mutant phenotype
18804096 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
16627783 MGI
acts upstream of or within blood vessel remodeling IMP
IMP: Inferred from mutant phenotype
16627783 MGI
acts upstream of or within enzyme-linked receptor protein signaling pathway IGI
IGI: Inferred from genetic interaction
9395235 MGI
acts upstream of or within erythrocyte homeostasis IGI
IGI: Inferred from genetic interaction
18188450 MGI
acts upstream of or within erythrocyte homeostasis IMP
IMP: Inferred from mutant phenotype
18188450 MGI
acts upstream of or within establishment of localization in cell IGI
IGI: Inferred from genetic interaction
19602523 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within forebrain cell migration IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
16627783 MGI
acts upstream of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
16751775 MGI
acts upstream of or within negative regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
9395235 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16627783 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
16723520 MGI
acts upstream of or within negative regulation of cytokine production IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within negative regulation of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within negative regulation of macrophage cytokine production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
18787040 MGI
acts upstream of or within negative regulation of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within neuron migration IMP
IMP: Inferred from mutant phenotype
19463168 MGI
acts upstream of or within neutrophil clearance IGI
IGI: Inferred from genetic interaction
23878224 MGI
acts upstream of or within ovulation cycle IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within phagocytosis IGI
IGI: Inferred from genetic interaction
19602523 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15650770 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16627783 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16723520 MGI
acts upstream of or within secretion by cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
10227296 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of tumor necrosis factor production IGI
IGI: Inferred from genetic interaction
16831897 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
18393392 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor UFO

adhesion-related kinase

ufo oncogene homolog

Recombinant Axl Proteins

Cat. No. Product Name Accession Purity
HY-P7623 AXL Protein, Mouse (HEK293, His) Q00993 (A19-P443) ≥95%
HY-P74406 AXL Protein, Mouse (HEK293, His-Fc) NP_033491.2 (H20-P443) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Axl NCBI NCBI:558
Macaca fascicularis Axl NCBI NCBI:102126361