2. Gene
  3. Axl - AXL receptor tyrosine kinase Gene

Axl - AXL receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ark; Ufo; Tyro7

Gene ID: 26362 | Gene type: protein coding

About Axl

Summary

Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; myeloid cell homeostasis; and negative regulation of tumor necrosis factor production. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Axl Products(3)

mRNA Protein Name
NM_001190974.1 NP_001177903.1 tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_001190975.1 NP_001177904.1 tyrosine-protein kinase receptor UFO isoform 3 precursor
NM_009465.4 NP_033491.2 tyrosine-protein kinase receptor UFO isoform 1 precursor
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor UFO

adhesion-related kinase

ufo oncogene homolog

Recombinant Axl Proteins

Cat. No. Product Name Accession Purity
HY-P7623 AXL Protein, Mouse (HEK293, His) Q00993 (A19-P443) ≥95%
HY-P74406 AXL Protein, Mouse (HEK293, His-Fc) NP_033491.2 (H20-P443) ≥95%

Related Agents

Approval
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13016 Cabozantinib Inhibitor 99.96% Yes
HY-12432 Gilteritinib Inhibitor 99.69% Yes
HY-12432A Gilteritinib hemifumarate Inhibitor 99.75% Yes
HY-13016A Cabozantinib hydrochloride Inhibitor / Unkown
Clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Phase
HY-138696 Zanzalintinib Inhibitor 99.73% Phase 3
HY-15150 Bemcentinib Inhibitor 99.92% Phase 2
HY-12963 Dubermatinib Inhibitor 99.84% Phase 2
HY-12076 BMS 777607 Inhibitor 99.33% Phase 2
HY-114358 Tamnorzatinib Inhibitor 98.07% Phase 2
HY-107145A Ningetinib Inhibitor 99.82% Phase 2
HY-107145 Ningetinib Tosylate Inhibitor 99.59% Phase 2
HY-15150G Bemcentinib (GMP) Inhibitor / Phase 2
HY-100946 CEP-40783 Inhibitor 99.12% Phase 1
Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P99463 Batiraxcept Inhibitor 96.40% Phase 3
HY-P99360 Enapotamab Inhibitor ≥95.0% Phase 2
HY-P99161 Tilvestamab Inhibitor 98.08% Phase 1
HY-P99734 Mipasetamab uzoptirine Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (37)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114166 2-D08 Inhibitor 98.44% Unkown
HY-12494 LDC1267 Inhibitor 99.58% Unkown
HY-15797 UNC2250 Inhibitor 99.92% Unkown
HY-117596 UNC569 Inhibitor 99.87% Unkown
HY-132200 UNC5293 Inhibitor 95.07% Unkown
HY-12964 SGI-7079 Inhibitor 99.59% Unkown
HY-117548 UNC1062 Inhibitor 99.48% Unkown
HY-15798 UNC2881 Inhibitor 99.79% Unkown
HY-100509 NPS-1034 Inhibitor ≥98.0% Unkown
HY-124066 RU-302 Inhibitor 98.02% Unkown
HY-13016S Cabozantinib-d6 Inhibitor 98.14% Unkown
HY-114357A DS-1205b free base Inhibitor 99.92% Unkown
HY-144627 PROTAC Axl Degrader 2 Inhibitor 98.01% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-151904 AXL-IN-13 Inhibitor 98.03% Unkown
HY-150041 TL4830031 Inhibitor ≥98.0% Unkown
HY-132893 AZ14145845 Inhibitor / Unkown
HY-146615 Axl-IN-6 Inhibitor / Unkown
HY-147576 Axl-IN-9 Inhibitor / Unkown
HY-149491 HIV-IN-7 Inhibitor / Unkown
HY-152075 AXL-IN-14 Inhibitor / Unkown
HY-147574 Axl-IN-7 Inhibitor / Unkown
HY-144708 Axl-IN-4 Inhibitor / Unkown
HY-147218 PF-07265807 Inhibitor 97.13% Unkown
HY-149092 Anticancer agent 109 / Unkown
HY-153012 Axl/Mer/CSF1R-IN-1 Inhibitor / Unkown
HY-N12041 Axl-IN-16 Inhibitor / Unkown
HY-104075 R916562 Inhibitor / Unkown
HY-144706 Axl-IN-3 Inhibitor / Unkown
HY-147577 Axl-IN-10 Inhibitor / Unkown
HY-162085 Axl-IN-17 Inhibitor / Unkown
HY-153441 AXL-IN-15 Inhibitor / Unkown
HY-144624 PROTAC Axl Degrader 1 Inhibitor / Unkown
HY-147579 Axl-IN-12 Inhibitor / Unkown
HY-147578 Axl-IN-11 Inhibitor / Unkown
HY-146596 Axl-IN-5 Inhibitor / Unkown
HY-147575 Axl-IN-8 Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99733 Mipasetamab Inhibitor / Unkown
HY-P9988 Mecbotamab Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Axl NCBI NCBI:558
Macaca fascicularis Axl NCBI NCBI:102126361