Axl - AXL receptor tyrosine kinase Gene

Mus musculus

Also known as Ark; Ufo; Tyro7

Gene ID: 26362 | Gene type: protein coding

About Axl

Summary

Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; myeloid cell homeostasis; and negative regulation of tumor necrosis factor production. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human Axl (Axl receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Axl Products(3)

mRNA	Protein	Name
NM_001190974.1	NP_001177903.1	tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_001190975.1	NP_001177904.1	tyrosine-protein kinase receptor UFO isoform 3 precursor
NM_009465.4	NP_033491.2	tyrosine-protein kinase receptor UFO isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18787040	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within apoptotic cell clearance	IGI IGI: Inferred from genetic interaction	17442946	MGI
involved in apoptotic cell clearance	IGI IGI: Inferred from genetic interaction	18159085	MGI
acts upstream of or within apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	18804096	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16627783	MGI
acts upstream of or within blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	16627783	MGI
acts upstream of or within enzyme-linked receptor protein signaling pathway	IGI IGI: Inferred from genetic interaction	9395235	MGI
acts upstream of or within erythrocyte homeostasis	IGI IGI: Inferred from genetic interaction	18188450	MGI
acts upstream of or within erythrocyte homeostasis	IMP IMP: Inferred from mutant phenotype	18188450	MGI
acts upstream of or within establishment of localization in cell	IGI IGI: Inferred from genetic interaction	19602523	MGI
acts upstream of or within establishment of localization in cell	IMP IMP: Inferred from mutant phenotype	15650770	MGI
acts upstream of or within forebrain cell migration	IGI IGI: Inferred from genetic interaction	18787040	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	16627783	MGI
acts upstream of lymphocyte activation	IGI IGI: Inferred from genetic interaction	11452127	MGI
acts upstream of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of or within natural killer cell differentiation	IGI IGI: Inferred from genetic interaction	16751775	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	9395235	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16627783	MGI
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16723520	MGI
acts upstream of or within negative regulation of cytokine production	IGI IGI: Inferred from genetic interaction	23878224	MGI
acts upstream of or within negative regulation of lymphocyte activation	IGI IGI: Inferred from genetic interaction	11452127	MGI
acts upstream of or within negative regulation of macrophage cytokine production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	18787040	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18787040	MGI
acts upstream of or within negative regulation of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of neuron apoptotic process	IGI IGI: Inferred from genetic interaction	18787040	MGI
acts upstream of or within neuron migration	IGI IGI: Inferred from genetic interaction	18787040	MGI
acts upstream of or within neuron migration	IMP IMP: Inferred from mutant phenotype	19463168	MGI
acts upstream of or within neutrophil clearance	IGI IGI: Inferred from genetic interaction	23878224	MGI
acts upstream of or within ovulation cycle	IGI IGI: Inferred from genetic interaction	18787040	MGI
acts upstream of or within phagocytosis	IGI IGI: Inferred from genetic interaction	19602523	MGI
acts upstream of or within platelet activation	IMP IMP: Inferred from mutant phenotype	15650770	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI IGI: Inferred from genetic interaction	15650770	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16627783	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	16723520	MGI
acts upstream of or within secretion by cell	IMP IMP: Inferred from mutant phenotype	15650770	MGI
acts upstream of or within spermatogenesis	IGI IGI: Inferred from genetic interaction	10227296	MGI
acts upstream of or within substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	15650770	MGI
acts upstream of tumor necrosis factor production	IGI IGI: Inferred from genetic interaction	16831897	MGI
acts upstream of or within vagina development	IGI IGI: Inferred from genetic interaction	18393392	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase receptor UFO

adhesion-related kinase

ufo oncogene homolog

Recombinant Axl Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7623	AXL Protein, Mouse (HEK293, His)	Q00993 (A19-P443)	≥95%
HY-P74406	AXL Protein, Mouse (HEK293, His-Fc)	NP_033491.2 (H20-P443)	≥95%

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.96%	Yes
HY-12432	Gilteritinib	Inhibitor	99.84%	Yes
HY-12432A	Gilteritinib hemifumarate	Inhibitor	99.75%	Yes
HY-13016A	Cabozantinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-138696	Zanzalintinib	Inhibitor	99.73%	Phase 3
HY-15150	Bemcentinib	Inhibitor	99.92%	Phase 2
HY-12963	Dubermatinib	Inhibitor	99.84%	Phase 2
HY-12076	BMS 777607	Inhibitor	99.33%	Phase 2
HY-114358	Tamnorzatinib	Inhibitor	98.07%	Phase 2
HY-107145A	Ningetinib	Inhibitor	99.82%	Phase 2
HY-107145	Ningetinib Tosylate	Inhibitor	99.59%	Phase 2
HY-100946	CEP-40783	Inhibitor	99.12%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99360	Enapotamab	Inhibitor	98.00%	Phase 2
HY-P99161	Tilvestamab	Inhibitor	98.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (39)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114166	2-D08	Inhibitor	99.17%	Unkown
HY-12494	LDC1267	Inhibitor	99.58%	Unkown
HY-15797	UNC2250	Inhibitor	99.92%	Unkown
HY-117596	UNC569	Inhibitor	99.87%	Unkown
HY-132200	UNC5293	Inhibitor	99.93%	Unkown
HY-12964	SGI-7079	Inhibitor	99.32%	Unkown
HY-117548	UNC1062	Inhibitor	99.48%	Unkown
HY-15798	UNC2881	Inhibitor	99.79%	Unkown
HY-100509	NPS-1034	Inhibitor	≥98.0%	Unkown
HY-124066	RU-302	Inhibitor	98.72%	Unkown
HY-13016S	Cabozantinib-d6	Inhibitor	98.14%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-144627	PROTAC Axl Degrader 2	Inhibitor	98.01%	Unkown
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-151904	AXL-IN-13	Inhibitor	98.03%	Unkown
HY-132893	AZ14145845	Inhibitor	/	Unkown
HY-147218	PF-07265807	Inhibitor	97.13%	Unkown
HY-150041	TL4830031	Inhibitor	≥98.0%	Unkown
HY-146615	Axl-IN-6	Inhibitor	/	Unkown
HY-15150G	Bemcentinib (GMP)	Inhibitor	/	Unkown
HY-152075	AXL-IN-14	Inhibitor	/	Unkown
HY-147577	Axl-IN-10	Inhibitor	/	Unkown
HY-162085	Axl-IN-17	Inhibitor	/	Unkown
HY-147574	Axl-IN-7	Inhibitor	/	Unkown
HY-144624	PROTAC Axl Degrader 1	Inhibitor	/	Unkown
HY-147579	Axl-IN-12	Inhibitor	/	Unkown
HY-147578	Axl-IN-11	Inhibitor	/	Unkown
HY-149092	Anticancer agent 109		/	Unkown
HY-147576	Axl-IN-9	Inhibitor	/	Unkown
HY-149491	HIV-IN-7	Inhibitor	/	Unkown
HY-N12041	Axl-IN-16	Inhibitor	/	Unkown
HY-104075	R916562	Inhibitor	/	Unkown
HY-173268	UNC9426	Inhibitor	/	Unkown
HY-144706	Axl-IN-3	Inhibitor	/	Unkown
HY-144708	Axl-IN-4	Inhibitor	/	Unkown
HY-153441	AXL-IN-15	Inhibitor	/	Unkown
HY-146596	Axl-IN-5	Inhibitor	/	Unkown
HY-147575	Axl-IN-8	Inhibitor	/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99463	Batiraxcept	Inhibitor	96.40%	Unkown
HY-P99733	Mipasetamab	Inhibitor	98.26%	Unkown
HY-P9988	Mecbotamab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Axl	NCBI	NCBI:558
Macaca fascicularis	Axl	NCBI	NCBI:102126361

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