AXL - AXL receptor tyrosine kinase Gene

Homo sapiens

Also known as ARK; UFO; JTK11; Tyro7

Gene ID: 558 | Gene type: protein coding

About AXL

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:41,219,223-41,261,766 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues, 53 paralogues and is associated with 1 phenotype. Ubiquitous expression in spleen (RPKM 20.7), endometrium (RPKM 15.3) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]

AXL Products(3)

mRNA	Protein	Name
NM_001278599.2	NP_001265528.1	tyrosine-protein kinase receptor UFO isoform 3
NM_001699.6	NP_001690.2	tyrosine-protein kinase receptor UFO isoform 2 precursor
NM_021913.5	NP_068713.2	tyrosine-protein kinase receptor UFO isoform 1 precursor

AXL Protein Structure

V-set

Ig_2

fn3

Pkinase_Tyr

0
200
400
600
800
894 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase receptor UFO

AXL oncogene

Recombinant AXL Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7622	AXL Protein, Human (415a.a, HEK293, His)	AAA61243 (A26-P440)	≥95%
HY-P74407	AXL Protein, Human (HEK293, His)	AAB20305.1 (E33-P449)	≥95%
HY-P77876	AXL Protein, Human (Biotinylated, HEK293, Fc)	P30530-1 (A26-P449)	≥95%
HY-P77877	AXL Protein, Human (HEK293, His-Avi)	P30530-1 (A26-P449)	≥95%
HY-P77878	AXL Protein, Human (Biotinylated, HEK293, His-Avi)	P30530-1 (A26-P449)	≥95%
HY-P77875	AXL Protein, Human (HEK293, Fc)	P30530-1 (A26-P449)	≥95%
HY-P700585	AXL Protein, Human (D266N, HEK293, His)	P30530-1 (A26-W451, D266N)	≥95%
HY-P700586	AXL Protein, Human (D266N, HEK293, hFc)	P30530-1 (A26-W451, D266N)	≥95%

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

Idiopathic Hypogonadotropic Hypogonadism	HH7
Hypogonadism, Isolated Hypogonadotropic	Ihh
Hypogonadism, Isolated, Hypogonadotropic	Hypogonadotropic Hypogonadism
Isolated Hypogonadotropic Hypogonadism	Hypogonadotropic Hypogonadism 7 Without Anosmia
Congenital Hypogonadotropic Hypogonadism Normosmic	Hh
Klinefelter Syndrome	Isolated Gonadotropin Deficiency

Nk-Cell Enteropathy

Lymphocytic Choriomeningitis

Lcm	Lymphocytic Meningitis
Lymphocytic Choriomeningitis Virus Encephalomyelitis	Lymphocytic Meningoencephalitis
Non-Arthropod Borne Lymphocytic Choriomeningitis	Lcm - [Lymphocytic Choriomeningitis]
Benign Lymphocytic Meningitis	Meningitis Due To Lymphocytic Choriomeningitis Virus

Mesangial Proliferative Glomerulonephritis

Glomerulonephritis - Mesangial Proliferative	Mesangial Proliferative Gn
Mesangioproliferative Glomerulonephritis	Glomerulonephritis Mesangial Proliferative

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Zika Fever

Zika Virus Infection	Zika Virus Disease
Zika Virus	Zika Virus Fever
Mosquito-Borne Viral Fever, Zika

Glomerulonephritis

Bright'S Disease

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia	Chronic Myelogenous Leukemia
CML	Chronic Granulocytic Leukemia
Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib	Chronic Myeloid Leukaemia
Chronic Granulocytic Leukaemia	Chronic Myelogenous Leukaemia
Myeloid Leukemia, Chronic	Leukemia, Chronic Myelogenous
Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic	Cml - Chronic Myelogenous Leukemia
Cgl	Chronic Myelocytic Leukemia
Leukemia, Chronic Myeloid, Atypical	ACML
Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative	Myeloid Leukemia Chronic
Leukemia, Myeloid, Chronic	Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative
Cml- [Chronic Myeloid Leukaemia]	Cgl - [Chronic Granulocytic Leukaemia]
Chronic Myelocytic Leukaemia

La Crosse Encephalitis

California Encephalitis	California Virus Encephalitis
Neuroinvasive California Encephalitis Virus Infection	Californian Encephalitis
Encephalitis, California	California Meningoencephalitis
California Encephalitis Virus Infection	California Encephalitis Virus Infection Neuroinvasive Disease
California Meningoencephalitis Virus Disease	California Serogroup Virus Neuroinvasive Disease
California Viral Encephalitis	Ce - [California Encephalitis]
Lac - [La Crosse Encephalitis]

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Refractive Error

Refractive Errors

Myeloproliferative Neoplasm

Myeloproliferative Disorder	Chronic Myeloproliferative Disease
Myeloproliferative Neoplasms	Chronic Myeloproliferative Disorder
Cmpd	Cmpd, U
Chronic Myeloproliferative Disorders	Mpd
Mpn	Myeloproliferative Disorders
Myeloproliferative Disease	Campomelic Dysplasia

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Parameningeal Embryonal Rhabdomyosarcoma

Diabetes Mellitus

Diabetes

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Gastrointestinal Stromal Tumor

GIST	Gastrointestinal Stromal Tumors
Gastrointestinal Stromal Sarcoma	Gastrointestinal Stromal Tumor, Familial
Gant	Gastrointestinal Stromal Tumour
Stromal Tumor Of Gastrointestinal Tract	Stromal Tumour Of Gastrointestinal Tract
Gastrointestinal Stromal Neoplasm	Paraganglioma And Gastric Stromal Sarcoma
Plexosarcoma

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Leukemia, Acute Myeloid

Acute Myeloid Leukemia	Leukemia, Acute Myelogenous
Acute Myelogenous Leukemia	AML
Leukemia, Acute Myeloid, Susceptibility To	Acute Myeloblastic Leukemia
Leukemia, Acute Myeloid, Reduced Survival In, Somatic	Acute Myeloid Leukaemia
Leukemia, Myelocytic, Acute	Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome
Secondary Aml	Acute Myelocytic Leukemia
Acute Myeloid Leukemia, Somatic	Leukemia, Acute Myeloid, Somatic
Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic	Acute Myeloblastic Leukaemia
Acute Myelogenous Leukaemia	Aml - Acute Myeloid Leukemia
Acute Myeloid Leukemia With Cebpa Somatic Mutations	Aml With Cebpa Somatic Mutations
Inherited Acute Myeloid Leukemia	Familial Aml
Inherited Aml	Pure Familial Aml
Pure Familial Acute Myeloid Leukemia	Secondary Acute Myeloid Leukemia
Therapy-Related Aml And Myelodysplastic Syndrome	Acute Myeloid Leukemia, Secondary
Acute Non-Lymphoblastic Leukemia	Acute Non-Lymphocytic Leukemia
Acute Biphenotypic Leukemia	Acute Undifferentiated Leukemia
Acute Myeloblastic Leukaemia With Multilineage Dysplasia	Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission
Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13016	Cabozantinib	Inhibitor	99.96%	Yes
HY-12432	Gilteritinib	Inhibitor	99.69%	Yes
HY-12432A	Gilteritinib hemifumarate	Inhibitor	99.75%	Yes
HY-13016A	Cabozantinib hydrochloride	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Phase
HY-138696	Zanzalintinib	Inhibitor	99.73%	Phase 3
HY-15150	Bemcentinib	Inhibitor	99.92%	Phase 2
HY-12963	Dubermatinib	Inhibitor	99.84%	Phase 2
HY-12076	BMS 777607	Inhibitor	99.33%	Phase 2
HY-114358	Tamnorzatinib	Inhibitor	98.07%	Phase 2
HY-107145A	Ningetinib	Inhibitor	99.82%	Phase 2
HY-107145	Ningetinib Tosylate	Inhibitor	99.59%	Phase 2
HY-15150G	Bemcentinib (GMP)	Inhibitor	/	Phase 2
HY-100946	CEP-40783	Inhibitor	99.12%	Phase 1

Inhibitory Antibodies (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99463	Batiraxcept	Inhibitor	96.40%	Phase 3
HY-P99360	Enapotamab	Inhibitor	≥95.0%	Phase 2
HY-P99161	Tilvestamab	Inhibitor	98.08%	Phase 1
HY-P99734	Mipasetamab uzoptirine	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (37)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114166	2-D08	Inhibitor	98.44%	Unkown
HY-12494	LDC1267	Inhibitor	99.58%	Unkown
HY-15797	UNC2250	Inhibitor	99.92%	Unkown
HY-117596	UNC569	Inhibitor	99.87%	Unkown
HY-132200	UNC5293	Inhibitor	95.07%	Unkown
HY-12964	SGI-7079	Inhibitor	99.59%	Unkown
HY-117548	UNC1062	Inhibitor	99.48%	Unkown
HY-15798	UNC2881	Inhibitor	99.79%	Unkown
HY-100509	NPS-1034	Inhibitor	≥98.0%	Unkown
HY-124066	RU-302	Inhibitor	98.02%	Unkown
HY-13016S	Cabozantinib-d6	Inhibitor	98.14%	Unkown
HY-114357A	DS-1205b free base	Inhibitor	99.92%	Unkown
HY-144627	PROTAC Axl Degrader 2	Inhibitor	98.01%	Unkown
HY-124502	UNC4203	Inhibitor	99.80%	Unkown
HY-151904	AXL-IN-13	Inhibitor	98.03%	Unkown
HY-150041	TL4830031	Inhibitor	≥98.0%	Unkown
HY-132893	AZ14145845	Inhibitor	/	Unkown
HY-146615	Axl-IN-6	Inhibitor	/	Unkown
HY-147576	Axl-IN-9	Inhibitor	/	Unkown
HY-152075	AXL-IN-14	Inhibitor	/	Unkown
HY-149491	HIV-IN-7	Inhibitor	/	Unkown
HY-147574	Axl-IN-7	Inhibitor	/	Unkown
HY-144708	Axl-IN-4	Inhibitor	/	Unkown
HY-147218	PF-07265807	Inhibitor	97.13%	Unkown
HY-149092	Anticancer agent 109		/	Unkown
HY-153012	Axl/Mer/CSF1R-IN-1	Inhibitor	/	Unkown
HY-N12041	Axl-IN-16	Inhibitor	/	Unkown
HY-104075	R916562	Inhibitor	/	Unkown
HY-144706	Axl-IN-3	Inhibitor	/	Unkown
HY-147577	Axl-IN-10	Inhibitor	/	Unkown
HY-162085	Axl-IN-17	Inhibitor	/	Unkown
HY-153441	AXL-IN-15	Inhibitor	/	Unkown
HY-144624	PROTAC Axl Degrader 1	Inhibitor	/	Unkown
HY-147579	Axl-IN-12	Inhibitor	/	Unkown
HY-147578	Axl-IN-11	Inhibitor	/	Unkown
HY-146596	Axl-IN-5	Inhibitor	/	Unkown
HY-147575	Axl-IN-8	Inhibitor	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99733	Mipasetamab	Inhibitor	/	Unkown
HY-P9988	Mecbotamab	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AXL	VGNC	VGNC:68890
Rattus norvegicus	AXL	RGD	RGD:620028
Canis familiaris	AXL	VGNC	VGNC:38326
Bos taurus	AXL	VGNC	VGNC:26366
Mus musculus	AXL	MGD	MGI:1347244
Macaca mulatta	AXL	VGNC	VGNC:70200
Macaca fascicularis	AXL	NCBI	NCBI:102126361
Others	AXL	NCBI

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