2. Gene
  3. Irak4 - interleukin-1 receptor-associated kinase 4 Gene

Irak4 - interleukin-1 receptor-associated kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IRAK-4; NY-REN-64; 8430405M07Rik; 9330209D03Rik

Gene ID: 266632 | Gene type: protein coding

About Irak4

Chromosome 15: 94,441,524-94,479,696 forward strand.GRCm39:CM001008.3

This gene has 3 transcripts (splice variants), 202 orthologues, 4 paralogues and is associated with 19 phenotypes. Ubiquitous expression in large intestine adult (RPKM 7.), colon adult (RPKM 5.3) and 25 other tissues.

Summary

Enables interleukin-1 receptor binding activity. Acts upstream of or within cytokine-mediated signaling pathway. Predicted to be located in extracellular space. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in central nervous system; dorsal aorta; genitourinary system; liver; and retina. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IRAK4 (interleukin 1 receptor associated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Irak4 Products(1)

mRNA Protein Name
NM_029926.5 NP_084202.2 interleukin-1 receptor-associated kinase 4
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables interleukin-1 receptor binding IPI
IPI: Inferred from physical interaction
15292196 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16306937 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cytokine production IDA
IDA: Inferred from direct assay
15292196 MGI
acts upstream of or within cytokine-mediated signaling pathway IDA
IDA: Inferred from direct assay
15292196 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Irak4 Protein Structure

Death_IRAK4

Death_IRAK4: cd08793 (8 - 107)

STKc_IRAK4

STKc_IRAK4: cd14158 (169 - 456)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 459 a.a.
Protein Preferred Names Protein Names

interleukin-1 receptor-associated kinase 4

Related Agents

Clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Phase
HY-19836 Zimlovisertib Inhibitor 99.94% Phase 2
HY-135317 Emavusertib Inhibitor 99.94% Phase 2
HY-145483 KT-474 Inhibitor 99.27% Phase 2
HY-139374 Zabedosertib Inhibitor 98.14% Phase 2
HY-135317B Emavusertib hydrochloride Inhibitor / Phase 2
HY-109585 IRAK4-IN-7 Inhibitor 99.36% Phase 1
Pre-clinical Phase
Bioactive Molecules (44)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147141 HS-276 Inhibitor 98.59% Unkown
HY-18992 AS2444697 Inhibitor 99.12% Unkown
HY-111101 AZ1495 Inhibitor 98.07% Unkown
HY-153188 JNJ-1013 Degrader 99.80% Unkown
HY-134911 HS-243 Inhibitor 99.88% Unkown
HY-129966 PROTAC IRAK4 degrader-1 Inhibitor 99.72% Unkown
HY-148290 KTX-951 Degrader 98.03% Unkown
HY-123854 PF-06426779 Inhibitor 99.89% Unkown
HY-160487 KME-2780 Inhibitor 98.94% Unkown
HY-153224 GLPG2534 Inhibitor 98.73% Unkown
HY-135382A PROTAC IRAK4 degrader-3 Inhibitor 97.22% Unkown
HY-146112 IRAK4-IN-14 Inhibitor 99.01% Unkown
HY-77048 IRAK-4 protein kinase inhibitor 2 Inhibitor 98.01% Unkown
HY-131903 HS271 Inhibitor 99.92% Unkown
HY-150735 IRAK4-IN-20 Inhibitor 96.05% Unkown
HY-13278A IRAK inhibitor 4 (trans) Inhibitor 99.02% Unkown
HY-143231 IRAK4-IN-8 Inhibitor / Unkown
HY-150593 IRAK4-IN-16 Inhibitor / Unkown
HY-139317 PROTAC IRAK4 degrader-6 Inhibitor / Unkown
HY-148277 KTX-612 / Unkown
HY-139316 PROTAC IRAK4 degrader-5 Inhibitor / Unkown
HY-161620 DW18134 Inhibitor / Unkown
HY-150732 IRAK4-IN-18 Inhibitor / Unkown
HY-146073 IRAK4-IN-12 Inhibitor / Unkown
HY-155574 IRAK4-IN-27 Inhibitor / Unkown
HY-149345 IRAK4-IN-24 Inhibitor / Unkown
HY-146111 IRAK4-IN-13 Inhibitor / Unkown
HY-123956 HG-12-6 Inhibitor / Unkown
HY-146072 IRAK4-IN-11 Inhibitor / Unkown
HY-139315 PROTAC IRAK4 degrader-4 Inhibitor / Unkown
HY-168611 PROTAC IRAK4 ligand-4 Degrader / Unkown
HY-162641 AF-45 Inhibitor / Unkown
HY-150594 IRAK4-IN-17 Inhibitor / Unkown
HY-135382 PROTAC IRAK4 degrader-2 Inhibitor / Unkown
HY-146113 IRAK4-IN-15 Inhibitor / Unkown
HY-148275 KTX-955 Inhibitor / Unkown
HY-160654 IRAK4 modulator-1 Modulator / Unkown
HY-148238 GNE-2256 Inhibitor / Unkown
HY-148276 KTX-497 / Unkown
HY-143486 IRAK4-IN-10 Inhibitor / Unkown
HY-143485 IRAK4-IN-9 Inhibitor / Unkown
HY-150733 IRAK4-IN-19 Inhibitor / Unkown
HY-162359 BIO-7488 Inhibitor 99.44% Unkown
HY-158374 BIO-8169 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Irak4 NCBI NCBI:51135