2. Gene
  3. HPGDS - hematopoietic prostaglandin D synthase Gene

HPGDS - hematopoietic prostaglandin D synthase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GSTS; PGD2; PGDS; GSTS1; GSTS1-1

Gene ID: 27306 | Gene type: protein coding

About HPGDS

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:94,298,535-94,342,836 (from NCBI)

This gene has 3 transcripts (splice variants), 134 orthologues and 11 paralogues. Broad expression in placenta (RPKM 12.7), lung (RPKM 6.6) and 16 other tissues.

Summary

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The Enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this Enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

HPGDS Products(1)

mRNA Protein Name
NM_014485.3 NP_055300.1 hematopoietic prostaglandin D synthase

HPGDS Protein Structure

GST_N

GST_N: Glutathione S-transferase, N-terminal domain (4 - 71)

GST_C

GST_C: Glutathione S-transferase, C-terminal domain (108 - 185)

  • 0
  • 100
  • 199 a.a.
Protein Preferred Names Protein Names

hematopoietic prostaglandin D synthase

GST class-sigma

Recombinant HPGDS Proteins

Cat. No. Product Name Accession Purity
HY-P71036 HPGDS Protein, Human O60760 (M1-L199) ≥95%

Related Diseases

Diseases Alias
O'Nyong'Nyong Fever

O'Nyong-Nyong Fever

O'Nyong-Nyong Mosquito-Borne Viral Fever

O'Nyong-Nyong Arthritis

Onn - [O'Nyong-Nyong Fever]
Intermediate Malignant Teratoma

Malignant Teratoma, Intermediate

Intermediate Immature Teratoma
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2

SRTD2

Atd2

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 2
Filarial Elephantiasis

Lymphatic Filariasis

Elephantiasis

Filariasis

Bancroftian Elephantiasis

Bancroftian Filarial Chyluria

Elephantiasis Of Eyelid

Bancroftian Filariasis

Elephantitis

Malayi Tropical Eosinphilia

Wuchereria Bancrofti Infection

Wuchereriasis

Elephantiasis, Filarial

Filarial Elephantiases

Infection By Wuchereria Bancrofti

Filarial Lymphangitis

Tropical Elephantiasis

Filarial Chylocele
Fascioliasis

Fasciola Hepatica Infection

Infection By Fasciola

Sheep Liver Fluke Infection

Liver Flukes

Fasciola Infestation

Sheep Liver Fluke Disease

Liver Fluke Infestation

Liver Flukes Nos

Liver Fluke Infection

Liver Fluke Disease
Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism
Skin Papilloma

Cutaneous Papilloma

Papilloma Of Skin

Papilloma Skin
Inflammatory Bowel Disease 16

IBD16

Inflammatory Bowel Disease 16, Susceptibility To
Methylmalonic Aciduria And Homocystinuria, Cbld Type

Homocystinuria, Cbld Type, Variant 1

Methylmalonic Aciduria And Homocystinuria Type Cbld

Vitamin B12-Responsive Methylmalonic Acidemia, Type Cbldv2

MAHCD

Methylmalonic Acidemia And Homocystinuria, Cbld Type

Methylmalonic Aciduria, Cblh Type, Formerly

Methylmalonic Acidemia, Cblh Type, Formerly

Methylmalonic Aciduria, Cbld Type, Variant 2

Cobalamin D Deficiency

Methylcobalamin Deficiency Type Cbldv1

Functional Methionine Synthase Deficiency Type Cbldv1

Vitamin B12-Responsive Methylmalonic Aciduria, Type Cbldv2

Methylmalonic Acidemia With Homocystinuria, Type Cbld

Cbld Defect

Cobalamin D Defect

Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cbld

Methylmalonic Aciduria With Homocystinuria, Type Cbld

Homocystinuria Cbld Variant 1

Methylmalonic Acidemia And Homocystinuria Cbld Type

Methylmalonic Aciduria And Homocystinuria Cbld-Combined

Methylmalonic Aciduria And Homocystinuria Cbld Original

Methylmalonic Aciduria Cbld Variant 2

Aciduria, Methylmalonic, And Homocystinuria, Cbld Type
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108259 HQL-79 Inhibitor 99.89% Unkown
HY-110167 TFC 007 Inhibitor 98.01% Unkown
HY-12791 hPGDS-IN-1 Inhibitor 99.92% Unkown
HY-109134 Pizuglanstat Inhibitor 99.70% Unkown
HY-139972 PROTAC(H-PGDS)-7 Inhibitor 99.42% Unkown
HY-10439 HPGDS inhibitor 1 Inhibitor 99.04% Unkown
HY-126134 HPGDS inhibitor 2 Inhibitor 99.72% Unkown
HY-146662 HPGDS inhibitor 3 Inhibitor / Unkown
HY-157577 PROTAC(H-PGDS)-8 Degrader / Unkown
HY-RS06338 HPGD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06339 Hpgd Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06340 Hpgd Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06341 HPGDS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-109134A Pizuglanstat hydrate Inhibitor / Unkown
HY-120581 ML388 Inhibitor / Unkown
HY-139171 F092 Inhibitor 99.79% Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HPGDS VGNC VGNC:54312
Felis catus HPGDS VGNC VGNC:62837
Macaca mulatta HPGDS VGNC VGNC:73410
Mus musculus HPGDS MGD MGI:1859384
Bos taurus HPGDS VGNC VGNC:29941
Rattus norvegicus HPGDS RGD RGD:69251
Others HPGDS NCBI