ARRDC3 - arrestin domain containing 3 Gene

Homo sapiens

Also known as TLIMP

Gene ID: 57561 | Gene type: protein coding

About ARRDC3

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:91,368,631-91,383,317 (from NCBI)

This gene has 7 transcripts (splice variants), 305 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 76.9), thyroid (RPKM 64.6) and 24 other tissues.

Summary

This gene encodes a member of the Arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast Cancer growth and progression by binding to a phosphorylated form of Integrin beta4, a tumor-related antigen, targeting the Integrin for internalization and degradation. [provided by RefSeq, Jul 2016]

ARRDC3 Products(4)

mRNA	Protein	Name
NM_001329670.2	NP_001316599.1	arrestin domain-containing protein 3 isoform b
NM_001329671.2	NP_001316600.1	arrestin domain-containing protein 3 isoform b
NM_001329672.2	NP_001316601.1	arrestin domain-containing protein 3 isoform b
NM_020801.4	NP_065852.1	arrestin domain-containing protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-3 adrenergic receptor binding	IDA IDA: Inferred from direct assay	21982743	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20603614	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	24114784	GOA
acts upstream of or within positive regulation of ubiquitin-protein transferase activity	IPI IPI: Inferred from physical interaction	23236378	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	23236378	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	23236378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARRDC3 Protein Structure

Arrestin_N

Arrestin_C

0
100
200
300
414 a.a.

Protein Preferred Names

Protein Names

arrestin domain-containing protein 3

TBP-2-like inducible membrane protein

ARRDC3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARRDC3	Q96B67	HPGDS	Homo sapiens	O60760	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	HPGDS	Homo sapiens	O60760	Y2H Array	25416956
Intra	ARRDC3	Q96B67	HPGDS	Homo sapiens	O60760	Y2H Array	32296183
Intra	ARRDC3	Q96B67	MORF4L1	Homo sapiens	Q9UBU8-2	Validated Y2H	25416956
Intra	ARRDC3	Q96B67	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	ARRDC3	Q96B67	EPN2	Homo sapiens	O95208-2	Y2H Array	32296183
Intra	ARRDC3	Q96B67	EPN2	Homo sapiens	O95208-2	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	RABGEF1	Homo sapiens	Q9UJ41-4	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Array	32296183
Intra	ARRDC3	Q96B67	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	33961781
Intra	ARRDC3	Q96B67	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	28514442
Intra	ARRDC3	Q96B67	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	23236378
Intra	ARRDC3	Q96B67	ITCH	Homo sapiens	Q96J02	Anti Tag CoIP	38270169
Intra	ARRDC3	Q96B67	ITCH	Homo sapiens	Q96J02	Y2H	23236378
Intra	ARRDC3	Q96B67	UBE2E2	Homo sapiens	Q96LR5	Validated Y2H	25416956
Intra	ARRDC3	Q96B67	UBE2E2	Homo sapiens	Q96LR5	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	25416956
Intra	ARRDC3	Q96B67	RAD18	Homo sapiens	Q9NS91	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	UBE2E3	Homo sapiens	Q969T4	Y2H Array	32296183
Intra	ARRDC3	Q96B67	UBA52	Homo sapiens	P62987	Y2H Array	32296183
Intra	ARRDC3	Q96B67	UBA52	Homo sapiens	P62987	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	SMARCD1	Homo sapiens	Q96GM5	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	STAM2	Homo sapiens	O75886	Validated Y2H	25416956
Intra	ARRDC3	Q96B67	STAM2	Homo sapiens	O75886	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	STAM2	Homo sapiens	O75886	Y2H Array	25416956
Intra	ARRDC3	Q96B67	STAM2	Homo sapiens	O75886	Y2H Array	32296183
Intra	ARRDC3	Q96B67	MORF4L1	Homo sapiens	Q9UBU8	Validated Y2H	25416956
Intra	ARRDC3	Q96B67	ADRB2	Homo sapiens	P07550	Confocal	23236378
Intra	ARRDC3	Q96B67	ADRB2	Homo sapiens	P07550	IF	23208550
Intra	ARRDC3	Q96B67	ADRB2	Homo sapiens	P07550	Anti Tag CoIP	23236378
Intra	ARRDC3	Q96B67	TRIM42	Homo sapiens	Q8IWZ5	Y2H Prey Pooling	25416956
Intra	ARRDC3	Q96B67	TRIM42	Homo sapiens	Q8IWZ5	Validated Y2H	25416956
Intra	ARRDC3	Q96B67	TRIM42	Homo sapiens	Q8IWZ5	Y2H Array	25416956
Intra	ARRDC3	Q96B67	TNFAIP3	Homo sapiens	P21580	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	TNFAIP3	Homo sapiens	P21580	Y2H Array	32296183
Intra	ARRDC3	Q96B67	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	ARRDC3	Q96B67	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	NEDD4L	Homo sapiens	Q96PU5-2	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	NEDD4L	Homo sapiens	Q96PU5	Anti Tag CoIP	38270169
Intra	ARRDC3	Q96B67	NEDD4L	Homo sapiens	Q96PU5	Anti Tag CoIP	33961781
Intra	ARRDC3	Q96B67	NEDD4L	Homo sapiens	Q96PU5	Y2H	23236378
Intra	ARRDC3	Q96B67	NEDD4L	Homo sapiens	Q96PU5	Anti Tag CoIP	23236378
Intra	ARRDC3	Q96B67	CCDC50	Homo sapiens	Q8IVM0	Y2H Array	32296183
Intra	ARRDC3	Q96B67	CCDC50	Homo sapiens	Q8IVM0	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	NEDD4	Homo sapiens	P46934	Anti Tag CoIP	33961781
Intra	ARRDC3	Q96B67	NEDD4	Homo sapiens	P46934	Confocal	23236378
Intra	ARRDC3	Q96B67	NEDD4	Homo sapiens	P46934	Anti Tag CoIP	38270169
Intra	ARRDC3	Q96B67	NEDD4	Homo sapiens	P46934	Anti Tag CoIP	23208550
Intra	ARRDC3	Q96B67	DCUN1D1	Homo sapiens	Q96GG9	Y2H Prey Pooling	25416956
Intra	ARRDC3	Q96B67	DCUN1D1	Homo sapiens	Q96GG9	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	DCUN1D1	Homo sapiens	Q96GG9	Y2H Array	25416956
Intra	ARRDC3	Q96B67	WWP1	Homo sapiens	Q9H0M0	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	WWP1	Homo sapiens	Q9H0M0	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	WWP1	Homo sapiens	Q9H0M0	Y2H Array	32296183
Intra	ARRDC3	Q96B67	WWP1	Homo sapiens	Q9H0M0	Anti Tag CoIP	38270169
Intra	ARRDC3	Q96B67	WWP1	Homo sapiens	Q9H0M0	Anti Tag CoIP	33961781
Intra	ARRDC3	Q96B67	WWP2	Homo sapiens	O00308	Anti Tag CoIP	23236378
Intra	ARRDC3	Q96B67	WWP2	Homo sapiens	O00308	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	WWP2	Homo sapiens	O00308	Y2H Array	32296183
Intra	ARRDC3	Q96B67	TOLLIP	Homo sapiens	Q9H0E2	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	OTUB2	Homo sapiens	Q96DC9	Y2H Prey Pooling	25416956
Intra	ARRDC3	Q96B67	OTUB2	Homo sapiens	Q96DC9	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	BAG3	Homo sapiens	O95817	Y2H Array	25416956
Intra	ARRDC3	Q96B67	BAG3	Homo sapiens	O95817	Y2H Prey Pooling	25416956
Intra	ARRDC3	Q96B67	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	OPTN	Homo sapiens	Q96CV9	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	OPTN	Homo sapiens	Q96CV9	Y2H Array	32296183
Intra	ARRDC3	Q96B67	UBAC1	Homo sapiens	Q9BSL1	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	UBAC1	Homo sapiens	Q9BSL1	Y2H Array	32296183
Intra	ARRDC3	Q96B67	UBAC1	Homo sapiens	Q9BSL1	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	BCL6	Homo sapiens	P41182	Y2H Array	32296183
Intra	ARRDC3	Q96B67	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	ARRDC3	Q96B67	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	ARRDC3	Q96B67	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	ARRDC3	Q96B67	ITGB4	Homo sapiens	P16144	Anti Bait CoIP	20603614
Intra	ARRDC3	Q96B67	ITGB4	Homo sapiens	P16144	Confocal	20603614

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01032	ARRDC3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARRDC3	VGNC	VGNC:38140
Rattus norvegicus	ARRDC3	RGD	RGD:1359478
Bos taurus	ARRDC3	VGNC	VGNC:26173
Macaca mulatta	ARRDC3	VGNC	VGNC:69923
Mus musculus	ARRDC3	MGD	MGI:2145242
Felis catus	ARRDC3	VGNC	VGNC:59945

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