EIF3K - eukaryotic translation initiation factor 3 subunit K Gene

Homo sapiens

Also known as M9; ARG134; PLAC24; PTD001; EIF3S12; HSPC029; MSTP001; PLAC-24; PRO1474; EIF3-p28

Gene ID: 27335 | Gene type: protein coding

About EIF3K

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,619,188-38,636,954 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele and 209 orthologues. Ubiquitous expression in heart (RPKM 136.4), duodenum (RPKM 100.7) and 25 other tissues.

Summary

The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 [PubMed 14519125]).[supplied by OMIM, Mar 2008]

EIF3K Products(3)

mRNA	Protein	Name
NM_001300992.2	NP_001287921.1	eukaryotic translation initiation factor 3 subunit K isoform 2
NM_001308393.2	NP_001295322.1	eukaryotic translation initiation factor 3 subunit K isoform 3
NM_013234.4	NP_037366.1	eukaryotic translation initiation factor 3 subunit K isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
contributes to translation initiation factor activity	IDA IDA: Inferred from direct assay	17581632	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in translational initiation	IDA IDA: Inferred from direct assay	17581632	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 3 complex	IDA IDA: Inferred from direct assay	17322308	GOA
part of eukaryotic translation initiation factor 3 complex	IPI IPI: Inferred from physical interaction	17322308	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EIF3K Protein Structure

CSN8_PSD8_EIF3K

0
100
200
218 a.a.

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 3 subunit K

eIF-3 p28

EIF3K Protein-protein interaction Information

Type Intra Cross	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EIF3K	Q9UBQ5	EIF3E	Homo sapiens	P60228	Anti Tag CoIP	35271311
Intra	EIF3K	Q9UBQ5	EIF3E	Homo sapiens	P60228	Pull Down	23623729
Intra	EIF3K	Q9UBQ5	EIF3L	Homo sapiens	Q9Y262	SLCA	18599441
Intra	EIF3K	Q9UBQ5	EIF3L	Homo sapiens	Q9Y262	Y2H	21516116
Intra	EIF3K	Q9UBQ5	EIF3L	Homo sapiens	Q9Y262	Y2H Pooling	16189514
Intra	EIF3K	Q9UBQ5	EIF3L	Homo sapiens	Q9Y262	Validated Y2H	32296183
Intra	EIF3K	Q9UBQ5	EIF3L	Homo sapiens	Q9Y262	Anti Tag CoIP	35271311
Intra	EIF3K	Q9UBQ5	EIF3L	Homo sapiens	Q9Y262	Pull Down	23623729
Intra	EIF3K	Q9UBQ5	EIF3L	Homo sapiens	Q9Y262	Y2H Array	25416956
Cross	EIF3K	Q9UBQ5	ORF	Human immunodeficiency virus	Q9Q2G4	Pull Down	22190034

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EIF3K Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76901	EIF3K Protein, Human (sf9, His-GST)	Q9UBQ5 (A2-Q218)	≥95%

Related Diseases

Diseases

Alias

Cardiomyopathy, Familial Hypertrophic, 11

Hypertrophic Cardiomyopathy 11	CMH11
Cardiomyopathy, Hypertrophic, 11	Cardiomyopathy Familial Hypertrophic 11
Cardiomyopathy, Familial Hypertrophic 11	Cardiomyopathy, Hypertrophic, Familial, Type 11

Arthrogryposis, Distal, Type 1a

Distal Arthrogryposis Type 1	Digitotalar Dysmorphism
DA1A	Da1
Amcd1	Arthrogryposis, Distal, Type 2b4
Distal Arthrogryposis Type 1a	Arthrogryposis, Distal, Type 1
Arthrogryposis Multiplex Congenita Distal Type 1	Arthrogryposis Multiplex Congenita, Distal Type 1
Arthrogryposis Multiplex Congenita, Distal, Type I	Distal Arthrogryposis Type 1b
Arthrogryposis, Distal, 1a	Amc
Arthrogryposis Multiplex Congenita	Arthrogryposis, Distal, 2b4
DA2B4	Arthrogryposis Multiplex Congenita, Distal, Type 1
Arthrogryposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS04267	EIF3K Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20014	Eif3k Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EIF3K	MGD	MGI:1921080
Canis familiaris	EIF3K	VGNC	VGNC:40277
Rattus norvegicus	EIF3K	RGD	RGD:1309221
Macaca mulatta	EIF3K	VGNC	VGNC:72102
Felis catus	EIF3K	VGNC	VGNC:61785
Bos taurus	EIF3K	VGNC	VGNC:28401
Others	EIF3K	NCBI

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