GPR25 - G protein-coupled receptor 25 Gene

Homo sapiens

Gene ID: 2848 | Gene type: protein coding

About GPR25

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:200,872,981-200,874,178 (from NCBI)

This gene has 1 transcript (splice variant), 153 orthologues and 7 paralogues.

Summary

This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]

GPR25 Products(1)

mRNA	Protein	Name
NM_005298.4	NP_005289.2	probable G-protein coupled receptor 25

GPR25 Protein Structure

7tm_1

0
100
200
300
361 a.a.

Protein Preferred Names

Protein Names

probable G-protein coupled receptor 25

GPR25 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GPR25	O00155	LDLRAD1	Homo sapiens	Q5T700	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	LDLRAD1	Homo sapiens	Q5T700	Y2H Array	32296183
Intra	GPR25	O00155	LDLRAD1	Homo sapiens	Q5T700	Validated Y2H	32296183
Intra	GPR25	O00155	VAPB	Homo sapiens	Q53XM7	Validated Y2H	25416956
Intra	GPR25	O00155	VAPB	Homo sapiens	Q53XM7	Y2H Prey Pooling	25416956
Intra	GPR25	O00155	NAALADL2	Homo sapiens	Q58DX5	Validated Y2H	25416956
Intra	GPR25	O00155	TMEM248	Homo sapiens	Q9NWD8	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	TMEM248	Homo sapiens	Q9NWD8	Validated Y2H	32296183
Intra	GPR25	O00155	TMEM248	Homo sapiens	Q9NWD8	Y2H Array	32296183
Intra	GPR25	O00155	CNIH4	Homo sapiens	Q9P003	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	CNIH4	Homo sapiens	Q9P003	Validated Y2H	32296183
Intra	GPR25	O00155	CNIH4	Homo sapiens	Q9P003	Y2H Array	32296183
Intra	GPR25	O00155	GGT7	Homo sapiens	Q9UJ14	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	GGT7	Homo sapiens	Q9UJ14	Validated Y2H	32296183
Intra	GPR25	O00155	GGT7	Homo sapiens	Q9UJ14	Y2H Array	32296183
Intra	GPR25	O00155	TMEM237	Homo sapiens	Q96Q45-2	Y2H Array	32296183
Intra	GPR25	O00155	TMEM237	Homo sapiens	Q96Q45-2	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	TMEM237	Homo sapiens	Q96Q45-2	Validated Y2H	32296183
Intra	GPR25	O00155	VAPB	Homo sapiens	O95292	Validated Y2H	32296183
Intra	GPR25	O00155	VAPB	Homo sapiens	O95292	Y2H Array	32296183
Intra	GPR25	O00155	STOM	Homo sapiens	P27105	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	STOM	Homo sapiens	P27105	Validated Y2H	32296183
Intra	GPR25	O00155	STOM	Homo sapiens	P27105	Y2H Array	32296183
Intra	GPR25	O00155	IKBIP	Homo sapiens	Q70UQ0-4	Validated Y2H	32296183
Intra	GPR25	O00155	IKBIP	Homo sapiens	Q70UQ0-4	Y2H Array	32296183
Intra	GPR25	O00155	IKBIP	Homo sapiens	Q70UQ0-4	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	RETN	Homo sapiens	Q9HD89	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	RETN	Homo sapiens	Q9HD89	Y2H Array	32296183
Intra	GPR25	O00155	RETN	Homo sapiens	Q9HD89	Validated Y2H	32296183
Intra	GPR25	O00155	ATP6V0E1	Homo sapiens	O15342	Validated Y2H	32296183
Intra	GPR25	O00155	ATP6V0E1	Homo sapiens	O15342	Y2H Array	32296183
Intra	GPR25	O00155	ATP6V0E1	Homo sapiens	O15342	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	GPR25	O00155	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	GPR25	O00155	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	SLC35E3	Homo sapiens	Q7Z769	Validated Y2H	32296183
Intra	GPR25	O00155	SLC35E3	Homo sapiens	Q7Z769	Y2H Array	32296183
Intra	GPR25	O00155	SLC35E3	Homo sapiens	Q7Z769	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	RHCG	Homo sapiens	Q9UBD6	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	RHCG	Homo sapiens	Q9UBD6	Validated Y2H	32296183
Intra	GPR25	O00155	RHCG	Homo sapiens	Q9UBD6	Y2H Array	32296183
Intra	GPR25	O00155	GJB1	Homo sapiens	P08034	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	GJB1	Homo sapiens	P08034	Validated Y2H	32296183
Intra	GPR25	O00155	GJB1	Homo sapiens	P08034	Y2H Array	32296183
Intra	GPR25	O00155	SHISAL1	Homo sapiens	Q3SXP7	Y2H Array	32296183
Intra	GPR25	O00155	SHISAL1	Homo sapiens	Q3SXP7	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	SHISAL1	Homo sapiens	Q3SXP7	Validated Y2H	32296183
Intra	GPR25	O00155	TMEM52B	Homo sapiens	Q4KMG9	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	TMEM52B	Homo sapiens	Q4KMG9	Validated Y2H	32296183
Intra	GPR25	O00155	TMEM52B	Homo sapiens	Q4KMG9	Y2H Array	32296183
Intra	GPR25	O00155	TPRA1	Homo sapiens	Q86W33-2	Validated Y2H	32296183
Intra	GPR25	O00155	TPRA1	Homo sapiens	Q86W33-2	Y2H Array	32296183
Intra	GPR25	O00155	TPRA1	Homo sapiens	Q86W33-2	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	BEST2	Homo sapiens	Q8NFU1	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	BEST2	Homo sapiens	Q8NFU1	Y2H Array	32296183
Intra	GPR25	O00155	BEST2	Homo sapiens	Q8NFU1	Validated Y2H	32296183
Intra	GPR25	O00155	TSPAN12	Homo sapiens	O95859	Y2H Array	32296183
Intra	GPR25	O00155	TSPAN12	Homo sapiens	O95859	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	TSPAN12	Homo sapiens	O95859	Validated Y2H	32296183
Intra	GPR25	O00155	SLCO4A1	Homo sapiens	Q96BD0	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	SLCO4A1	Homo sapiens	Q96BD0	Y2H Array	32296183
Intra	GPR25	O00155	SLCO4A1	Homo sapiens	Q96BD0	Validated Y2H	32296183
Intra	GPR25	O00155	PNMA1	Homo sapiens	Q8ND90	Validated Y2H	25416956
Intra	GPR25	O00155	MFSD5	Homo sapiens	Q6N075	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	MFSD5	Homo sapiens	Q6N075	Validated Y2H	32296183
Intra	GPR25	O00155	MFSD5	Homo sapiens	Q6N075	Y2H Array	32296183
Intra	GPR25	O00155	SLC16A7	Homo sapiens	O60669	Validated Y2H	32296183
Intra	GPR25	O00155	SLC16A7	Homo sapiens	O60669	Y2H Array	32296183
Intra	GPR25	O00155	SLC16A7	Homo sapiens	O60669	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	GPR25	O00155	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	GPR25	O00155	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	GPR25	O00155	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	GPR25	O00155	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	31515488
Intra	GPR25	O00155	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	ATP6V0C	Homo sapiens	P27449	Validated Y2H	32296183
Intra	GPR25	O00155	ATP6V0C	Homo sapiens	P27449	Y2H Array	32296183
Intra	GPR25	O00155	ATP6V0C	Homo sapiens	P27449	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956
Intra	GPR25	O00155	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	GPR25	O00155	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	GPR25	O00155	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	GPR25	O00155	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	25416956
Intra	GPR25	O00155	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	GPR25	O00155	CREB3L3	Homo sapiens	Q68CJ9	Y2H Prey Pooling	32296183
Intra	GPR25	O00155	CREB3L3	Homo sapiens	Q68CJ9	Validated Y2H	32296183
Intra	GPR25	O00155	CREB3L3	Homo sapiens	Q68CJ9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2196A	ELA-32(human) TFA	Agonist	99.27%	Unkown
HY-RS05697	GPR25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPR25	VGNC	VGNC:82435
Rattus norvegicus	GPR25	RGD	RGD:1311611
Macaca mulatta	GPR25	VGNC	VGNC:73130
Bos taurus	GPR25	VGNC	VGNC:106757
Canis familiaris	GPR25	VGNC	VGNC:41427
Mus musculus	GPR25	MGD	MGI:2686146

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