TSPAN12 - tetraspanin 12 Gene

Homo sapiens

Also known as EVR5; NET2; NET-2; TM4SF12

Gene ID: 23554 | Gene type: protein coding

About TSPAN12

Cytogenetic location: 7q31.31 Genomic coordinates (GRCh38): 7:120,787,320-120,858,335 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues, 32 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 32.8), adrenal (RPKM 28.5) and 21 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]

TSPAN12 Products(1)

mRNA	Protein	Name
NM_012338.4	NP_036470.1	tetraspanin-12

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19587294	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN12 Protein Structure

Tetraspannin

0
100
200
305 a.a.

Protein Preferred Names

Protein Names

tetraspanin-12

tetraspan NET-2

TSPAN12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TSPAN12	O95859	TMEM182	Homo sapiens	Q6ZP80	Validated Y2H	32296183
Intra	TSPAN12	O95859	NINJ2	Homo sapiens	Q9NZG7	Validated Y2H	32296183
Intra	TSPAN12	O95859	MARCHF2	Homo sapiens	Q9P0N8	Validated Y2H	32296183
Intra	TSPAN12	O95859	TEX264	Homo sapiens	Q9Y6I9	Validated Y2H	32296183
Intra	TSPAN12	O95859	CTXN3	Homo sapiens	Q4LDR2	Validated Y2H	32296183
Intra	TSPAN12	O95859	ADAM10	Homo sapiens	O14672	Anti Bait CoIP	19587294
Intra	TSPAN12	O95859	ADAM10	Homo sapiens	O14672	Anti Tag CoIP	19587294
Intra	TSPAN12	O95859	O14672-PRO_0000029067	Homo sapiens	O14672-PRO_0000029067	Anti Tag CoIP	19587294
Intra	TSPAN12	O95859	RNF152	Homo sapiens	Q8N8N0	Validated Y2H	32296183
Intra	TSPAN12	O95859	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	TSPAN12	O95859	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	TSPAN12	O95859	PMP22	Homo sapiens	Q01453	Validated Y2H	32296183
Intra	TSPAN12	O95859	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	TSPAN12	O95859	EMP3	Homo sapiens	P54852	Validated Y2H	32296183
Intra	TSPAN12	O95859	RFT1	Homo sapiens	Q96AA3	Validated Y2H	32296183
Intra	TSPAN12	O95859	IGFBP5	Homo sapiens	P24593	Validated Y2H	32296183
Intra	TSPAN12	O95859	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Exudative Vitreoretinopathy 5

EVR5	Vitreoretinopathy, Exudative 5
Vitreoretinopathy, Exudative, Type 5

Vitreoretinopathy

Persistent Hyperplastic Primary Vitreous, Autosomal Recessive

PHPVAR	Retinal Nonattachment, Nonsyndromic Congenital
Rnanc	Persistent Fetal Vasculature
Retinal Nonattachment And Falciform Detachment	Congenital Non-Syndromic Retinal Non-Attachment
Ncrna	Retinal Detachment Congenital
Retinal Non-Attachment And Falciform Detachment	Vitreous, Primary, Hyperplastic, Persistent, Autosomal Recessive

Vitreoretinal Degeneration

Norrie Disease

Atrophia Bulborum Hereditaria	Episkopi Blindness
Pseudoglioma	ND
Norrie-Warburg Disease	Anderson-Warburg Syndrome
Fetal Iritis Syndrome	Norrie Syndrome
Norrie-Warburg Syndrome	Ndp
Congenital Progressive Oculo-Acoustico-Cerebral Degeneration	Norrie'S Disease
Oligophrenia Microphthalmus	Pseudoglioma Congenita
Whitnall-Norman Syndrome

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy	Fevr
Criswick-Schepens Syndrome	Exudative Vitreoretinopathy, Familial
Vitreoretinopathy, Exudative )	Exudative Vitreoretinopathy 1

Retinal Detachment

Retinal Detachments	Rhegmatogenous Retinal Detachment
Ruptured Retina With Detachment	Retinal Hole With Detachment

Leukocoria

Leucocoria

Retinal Telangiectasia

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Exudative Vitreoretinopathy 1

Retinopathy Of Prematurity	Retrolental Fibroplasia
EVR1	Criswick-Schepens Syndrome
Rop	Exudative Vitreoretinopathy, Familial, Autosomal Dominant
Fevr, Autosomal Dominant	Premature Retinopathy
Vitreoretinopathy, Exudative 1	Autosomal Dominant Familial Exudative Vitreoretinopathy
Fevr	Vitreoretinopathy, Exudative, Type 1
Retinopathy Of Prematurity Nos	Rlf- [Retrolental Fibroplasia]
Rop - [Retinopathy Of Prematurity]	Terry Syndrome

Persistent Hyperplastic Primary Vitreous

Congenital Retinal Detachment	Ncrna Disease
Non-Syndromic Congenital Retinal Non-Attachment	Pfvs
Phpv	Persistent Fetal Vasculature Syndrome

Coats Disease

Exudative Retinopathy	Retinal Telangiectasis
Coats' Disease	Leber Miliary Aneurysm
Coats' Syndrome	Congenital Retinal Telangiectasia

Peripheral Retinal Degeneration

Peripheral Degeneration Of Retina	Degeneration Of Retina Nos
Reticular Retinal Degeneration	Retinal Degeneration

Hypotropia

Retinal Vascular Disease

Retinal Vascular	Retinal Vascular Disorder
Retina Circulation Disorder

Vitreoretinal Dystrophy

Vitreoretinal Dystrophies

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Eye Disease

Eye Diseases	Abnormality Of The Eye
Toxoplasma Oculopathy

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15160	TSPAN12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TSPAN12	MGD	MGI:1889818
Macaca mulatta	TSPAN12	VGNC	VGNC:79328
Rattus norvegicus	TSPAN12	RGD	RGD:1311102
Felis catus	TSPAN12	VGNC	VGNC:66626
Bos taurus	TSPAN12	VGNC	VGNC:36427
Canis familiaris	TSPAN12	VGNC	VGNC:47912

Name
Email *

	Sorry, but the email address you supplied was invalid.