CREB3L3 - cAMP responsive element binding protein 3 like 3 Gene

Homo sapiens

Also known as CREBH; HYTG2; CREB-H; HYST1481

Gene ID: 84699 | Gene type: protein coding

About CREB3L3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,153,631-4,173,054 (from NCBI)

This gene has 5 transcripts (splice variants), 246 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue.

Summary

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

CREB3L3 Products(4)

mRNA	Protein	Name
NM_001271995.2	NP_001258924.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b
NM_001271996.2	NP_001258925.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform c
NM_001271997.2	NP_001258926.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform d
NM_032607.3	NP_115996.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11353085	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	11353085	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11353085	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20102225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16469704	GOA
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	16469704	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	16469704	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	16469704	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16469704	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11353085	GOA
involved in response to endoplasmic reticulum stress	IDA IDA: Inferred from direct assay	16469704	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16236796	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16469704	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CREB3L3 Protein Structure

bZIP_1

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 3

CREB/ATF family transcription factor

CREB3L3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CREB3L3	Q68CJ9	CYB561A3	Homo sapiens	Q8NBI2	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	SLC38A7	Homo sapiens	Q9NVC3	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	TMEM239	Homo sapiens	Q8WW34-2	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	SLC39A9	Homo sapiens	Q9NUM3	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	NFIL3	Homo sapiens	Q16649	Peptide Array	20102225
Intra	CREB3L3	Q68CJ9	CREB3	Homo sapiens	O43889	FRET	23661758
Intra	CREB3L3	Q68CJ9	CREB3L1	Homo sapiens	Q96BA8	FRET	23661758
Intra	CREB3L3	Q68CJ9	CEP19	Homo sapiens	Q96LK0	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	DPY30	Homo sapiens	Q9C005	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	YIPF6	Homo sapiens	Q96EC8	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	RUSF1	Homo sapiens	Q96GQ5	Validated Y2H	32296183
Intra	CREB3L3	Q68CJ9	CREB3L3	Homo sapiens	Q68CJ9	FRET	23661758
Intra	CREB3L3	Q68CJ9	CREB3L3	Homo sapiens	Q68CJ9	Peptide Array	20102225

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypertriglyceridemia 2

HYTG2

Hypertriglyceridemia 1

Hypertriglyceridemia	Hypertriglyceridemia, Familial
Hypertriglyceridemia, Susceptibility To	HYTG1
FHTR	Hypertriglyceridemias Familial

Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T	PLSDT
Platyspondylic Dysplasia, Torrance Type	Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type
Thanatophoric Dysplasia, Torrance Variant	Platyspondylic Skeletal Dysplasia, Torrance Type
Torrance Type Platyspondylic Dysplasia	Platyspondylic Dysplasia, Torrance-Luton Type
Platyspondylic Lethal Skeletal Dysplasia Torrance Type	Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type
Thanatophoric Dysplasia Torrance Variant	Platyspondylic Chondrodysplasia, Torrance-Luton Type
Plsd-Tl	Dysplasia, Skeletal, Platyspondylic, Torrance Type

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Osteogenesis Imperfecta, Type Xix

OI19	Osteogenesis Imperfecta Type 19
Osteogenesis Imperfecta Type Xix	Osteogenesis Imperfecta, Type 19
Osteogenesis Imperfecta 19

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03152	CREB3L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CREB3L3	RGD	RGD:1308152
Macaca mulatta	CREB3L3	VGNC	VGNC:109609
Canis familiaris	CREB3L3	VGNC	VGNC:54593
Mus musculus	CREB3L3	MGD	MGI:2384786
Bos taurus	CREB3L3	VGNC	VGNC:27696
Felis catus	CREB3L3	VGNC	VGNC:61168

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