GPR37 - G protein-coupled receptor 37 Gene

Homo sapiens

Also known as PAELR; EDNRBL; hET(B)R-LP

Gene ID: 2861 | Gene type: protein coding

About GPR37

Cytogenetic location: 7q31.33 Genomic coordinates (GRCh38): 7:124,743,885-124,765,792 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues and 15 paralogues. Biased expression in brain (RPKM 26.2), testis (RPKM 10.2) and 4 other tissues.

Summary

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

GPR37 Products(1)

mRNA	Protein	Name
NM_005302.5	NP_005293.1	prosaposin receptor GPR37 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled peptide receptor activity	IDA IDA: Inferred from direct assay	23690594	GOA
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables neuropeptide binding	IPI IPI: Inferred from physical interaction	16443751	GOA
enables neuropeptide receptor activity	IDA IDA: Inferred from direct assay	16443751	GOA
enables peptide binding	IPI IPI: Inferred from physical interaction	23690594	GOA
enables prosaposin receptor activity	IDA IDA: Inferred from direct assay	23690594	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11439185	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	23690594	GOA
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	16443751	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	23690594	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16443751	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16443751	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17059562	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11439185	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12150907	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR37 Protein Structure

7tm_1

0
100
200
300
400
500
613 a.a.

Protein Preferred Names

Protein Names

prosaposin receptor GPR37

ETBR-LP-1

Related Diseases

Diseases

Alias

Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease

Epilepsy, Familial Temporal Lobe, 6

ETL6	Familial Temporal Lobe Epilepsy 6

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05709	GPR37 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05710	GPR37L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPR37	VGNC	VGNC:80054
Mus musculus	GPR37	MGD	MGI:1313297
Macaca mulatta	GPR37	VGNC	VGNC:73135
Rattus norvegicus	GPR37	RGD	RGD:619848
Bos taurus	GPR37	VGNC	VGNC:29585
Canis familiaris	GPR37	VGNC	VGNC:41432
Others	GPR37	NCBI

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