SCAMP4 - secretory carrier membrane protein 4 Gene

Homo sapiens

Also known as SCAMP-4

Gene ID: 113178 | Gene type: protein coding

About SCAMP4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,905,399-1,926,013 (from NCBI)

This gene has 13 transcripts (splice variants), 196 orthologues and 4 paralogues. Ubiquitous expression in prostate (RPKM 16.8), thyroid (RPKM 14.8) and 25 other tissues.

Summary

Secretory carrier membrane proteins (SCAMPs) are widely distributed integral membrane proteins implicated in membrane trafficking. Most SCAMPs (e.g., SCAMP1; MIM 606911) have N-terminal cytoplasmic NPF (arg-pro-phe) repeats, 4 central transmembrane regions, and a short C-terminal cytoplasmic tail. These SCAMPs likely have a role in endocytosis that is mediated by their NPF repeats. Other SCAMPs, such as SCAMP4, lack the NPF repeats and are therefore unlikely to function in endocytosis (summary by Fernandez-Chacon and Sudhof, 2000 [PubMed 11050114]).[supplied by OMIM, Feb 2011]

SCAMP4 Products(3)

mRNA	Protein	Name
NM_001329539.2	NP_001316468.1	secretory carrier-associated membrane protein 4 isoform 2
NM_001329540.2	NP_001316469.1	secretory carrier-associated membrane protein 4 isoform 3
NM_079834.4	NP_524558.1	secretory carrier-associated membrane protein 4 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SCAMP4 Protein Structure

SCAMP

0
100
200
229 a.a.

Protein Preferred Names

Protein Names

secretory carrier-associated membrane protein 4

SCAMP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SCAMP4	Q969E2	SPAG4	Homo sapiens	Q9NPE6	Y2H Array	32296183
Intra	SCAMP4	Q969E2	SPAG4	Homo sapiens	Q9NPE6	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	SPAG4	Homo sapiens	Q9NPE6	Validated Y2H	32296183
Intra	SCAMP4	Q969E2	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	SCAMP4	Q969E2	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SCAMP4	Q969E2	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	SCAMP4	Q969E2	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	EVI2B	Homo sapiens	P34910-2	Y2H Array	32296183
Intra	SCAMP4	Q969E2	EVI2B	Homo sapiens	P34910-2	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	SCAMP4	Q969E2	CGRRF1	Homo sapiens	Q99675	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	CGRRF1	Homo sapiens	Q99675	Validated Y2H	32296183
Intra	SCAMP4	Q969E2	CGRRF1	Homo sapiens	Q99675	Y2H Array	32296183
Intra	SCAMP4	Q969E2	GRN	Homo sapiens	P28799-2	Validated Y2H	32814053
Intra	SCAMP4	Q969E2	GRN	Homo sapiens	P28799-2	Y2H Pooling	32814053
Intra	SCAMP4	Q969E2	GRN	Homo sapiens	P28799-2	Y2H Array	32814053
Intra	SCAMP4	Q969E2	TMEM147	Homo sapiens	Q9BVK8	Validated Y2H	32296183
Intra	SCAMP4	Q969E2	TMEM147	Homo sapiens	Q9BVK8	Y2H Array	32296183
Intra	SCAMP4	Q969E2	TMEM147	Homo sapiens	Q9BVK8	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	SCAMP4	Q969E2	ABHD6	Homo sapiens	Q9BV23	Validated Y2H	32296183
Intra	SCAMP4	Q969E2	ABHD6	Homo sapiens	Q9BV23	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	ABHD6	Homo sapiens	Q9BV23	Y2H Array	32296183
Intra	SCAMP4	Q969E2	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
Intra	SCAMP4	Q969E2	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	BIK	Homo sapiens	Q13323	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	BIK	Homo sapiens	Q13323	Y2H Array	32296183
Intra	SCAMP4	Q969E2	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SCAMP4	Q969E2	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SCAMP4	Q969E2	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	SCAMP4	Q969E2	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	SCAMP4	Q969E2	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	SCAMP4	Q969E2	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	CLDN7	Homo sapiens	O95471	Y2H Prey Pooling	32296183
Intra	SCAMP4	Q969E2	CLDN7	Homo sapiens	O95471	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Brain Abnormalities, Poor Growth, And Dysmorphic Facies

Intellectual Disability-Strabismus Syndrome	NEDBGF
Mental Retardation, Autosomal Recessive 36, Formerly	Mrt36, Formerly
Autosomal Recessive Mental Retardation 36	Mrt36
Mental Retardation, Autosomal Recessive, Type 36

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12481	SCAMP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SCAMP4	MGD	MGI:1928947
Bos taurus	SCAMP4	VGNC	VGNC:34318
Macaca mulatta	SCAMP4	VGNC	VGNC:77135
Felis catus	SCAMP4	VGNC	VGNC:80712
Canis familiaris	SCAMP4	VGNC	VGNC:45892
Rattus norvegicus	SCAMP4	RGD	RGD:68354

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