PATL1 - PAT1 homolog 1, processing body mRNA decay factor Gene

Homo sapiens

Also known as Pat1b; hPat1b

Gene ID: 219988 | Gene type: protein coding

About PATL1

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,636,716-59,669,037 (from NCBI)

This gene has 2 transcripts (splice variants), 206 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 16.7), placenta (RPKM 9.5) and 25 other tissues.

Summary

Enables poly(G) binding activity and poly(U) RNA binding activity. Involved in P-body assembly and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body and cytosol. Colocalizes with CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2022]

PATL1 Products(1)

mRNA	Protein	Name
NM_152716.3	NP_689929.2	protein PAT1 homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	20543818	GOA
enables poly(G) binding	IDA IDA: Inferred from direct assay	20826699	GOA
enables poly(U) RNA binding	IDA IDA: Inferred from direct assay	20826699	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20543818	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in P-body assembly	IDA IDA: Inferred from direct assay	20584987	GOA
involved in deadenylation-dependent decapping of nuclear-transcribed mRNA	IDA IDA: Inferred from direct assay	20584987	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of CCR4-NOT complex	IDA IDA: Inferred from direct assay	20584987	GOA
located in P-body	IDA IDA: Inferred from direct assay	20543818	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PATL1 Protein Structure

PAT1

0
200
400
600
770 a.a.

Protein Preferred Names

Protein Names

protein PAT1 homolog 1

PAT1-like protein 1

PATL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PATL1	Q86TB9	NFKBID	Homo sapiens	Q8NI38	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	NFKBID	Homo sapiens	Q8NI38	Validated Y2H	32296183
Intra	PATL1	Q86TB9	NFKBID	Homo sapiens	Q8NI38	Y2H Array	32296183
Intra	PATL1	Q86TB9	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	PATL1	Q86TB9	ZMYND12	Homo sapiens	Q9H0C1	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	ZMYND12	Homo sapiens	Q9H0C1	Validated Y2H	32296183
Intra	PATL1	Q86TB9	ZMYND12	Homo sapiens	Q9H0C1	Y2H Array	32296183
Intra	PATL1	Q86TB9	WWOX	Homo sapiens	Q9NZC7-5	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	WWOX	Homo sapiens	Q9NZC7-5	Validated Y2H	32296183
Intra	PATL1	Q86TB9	WWOX	Homo sapiens	Q9NZC7-5	Y2H Array	32296183
Intra	PATL1	Q86TB9	CNOT1	Homo sapiens	A5YKK6	Anti Tag CoIP	20584987
Intra	PATL1	Q86TB9	TSC1	Homo sapiens	Q86WV8	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	TSC1	Homo sapiens	Q86WV8	Validated Y2H	32296183
Intra	PATL1	Q86TB9	TSC1	Homo sapiens	Q86WV8	Y2H Array	32296183
Intra	PATL1	Q86TB9	CNOT6	Homo sapiens	Q9ULM6	Anti Tag CoIP	20584987
Intra	PATL1	Q86TB9	CNOT7	Homo sapiens	Q9UIV1	Anti Tag CoIP	20584987
Intra	PATL1	Q86TB9	LSM2	Homo sapiens	Q9Y333	Validated Y2H	32296183
Intra	PATL1	Q86TB9	LSM2	Homo sapiens	Q9Y333	Y2H Array	32296183
Intra	PATL1	Q86TB9	LSM2	Homo sapiens	Q9Y333	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	LSM1	Homo sapiens	O15116	Y2H Array	32296183
Intra	PATL1	Q86TB9	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	LSM1	Homo sapiens	O15116	Anti Tag CoIP	20584987
Intra	PATL1	Q86TB9	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	PATL1	Q86TB9	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	PATL1	Q86TB9	DDX6	Homo sapiens	P26196	Anti Tag CoIP	20584987
Intra	PATL1	Q86TB9	LSM6	Homo sapiens	P62312	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	LSM6	Homo sapiens	P62312	Y2H Array	32296183
Intra	PATL1	Q86TB9	DCP1A	Homo sapiens	Q9NPI6	Anti Tag CoIP	20584987
Intra	PATL1	Q86TB9	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	PATL1	Q86TB9	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	32296183
Intra	PATL1	Q86TB9	FHL3	Homo sapiens	Q13643	Y2H Array	25416956
Intra	PATL1	Q86TB9	FHL3	Homo sapiens	Q13643	Y2H Array	32296183
Intra	PATL1	Q86TB9	FHL3	Homo sapiens	Q13643	Y2H Prey Pooling	25416956
Intra	PATL1	Q86TB9	CNOT8	Homo sapiens	Q9UFF9	Anti Tag CoIP	20584987

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome 7

HPS7	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 7
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Retinitis Pigmentosa 13

RP13	Retinitis Pigmentosa-13
Retinitis Pigmentosa, Type 13

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10084	PATL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PATL1	VGNC	VGNC:44272
Macaca mulatta	PATL1	VGNC	VGNC:75684
Mus musculus	PATL1	MGD	MGI:2147679
Felis catus	PATL1	VGNC	VGNC:64049
Bos taurus	PATL1	VGNC	VGNC:32593
Rattus norvegicus	PATL1	RGD	RGD:1305514

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