1. Gene
  2. Lrrk2 - leucine-rich repeat kinase 2 Gene

Lrrk2 - leucine-rich repeat kinase 2 Gene

Rattus norvegicus
Gene ID: 300160 | Gene type: protein coding

About Lrrk2

Primary_assembly 7: 122,826,696-122,987,703 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Biased expression in Lung (RPKM 24.9), Spleen (RPKM 172.7) and 8 other tissues.

Summary

Predicted to enable several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and positive regulation of microglial cell activation. Located in several cellular components, including axon; dendrite; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 Products(1)

mRNA Protein Name
NM_001191789.2 NP_001178718.2 leucine-rich repeat serine/threonine-protein kinase 2
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19879924 RGD
involved in negative regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17114044 RGD
involved in neuron projection arborization IMP
IMP: Inferred from mutant phenotype
17114044 RGD
involved in positive regulation of microglial cell activation IMP
IMP: Inferred from mutant phenotype
22302802 RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process IMP
IMP: Inferred from mutant phenotype
22302802 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
18445495 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
22302802 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
20403420 RGD
involved in striatum development IEP
IEP: Inferred from expression pattern
18272292 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
17114044 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17114044 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
18445495 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17114044 RGD
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
18445495 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lrrk2 Protein Structure

LRR_RI

LRR_RI: sd00033 (983 - 1010)

PRK15370

PRK15370: cl33128 (1009 - 1257)

LRR_RI

LRR_RI: sd00033 (1011 - 1034)

LRR_RI

LRR_RI: sd00033 (1035 - 1057)

LRR_RI

LRR_RI: sd00033 (1058 - 1082)

LRR_RI

LRR_RI: sd00033 (1083 - 1106)

LRR_RI

LRR_RI: sd00033 (1107 - 1128)

LRR_RI

LRR_RI: sd00033 (1129 - 1172)

LRR_RI

LRR_RI: sd00033 (1173 - 1195)

LRR_RI

LRR_RI: sd00033 (1196 - 1219)

LRR_RI

LRR_RI: sd00033 (1220 - 1244)

RocCOR

RocCOR: cd09914 (1332 - 1505)

COR

COR: cl24610 (1525 - 1738)

STKc_LRRK2

STKc_LRRK2: cd14068 (1882 - 2133)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2400
  • 2526 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrk2 NCBI NCBI:120892