Lrrk2 - leucine-rich repeat kinase 2 Gene

Rattus norvegicus

Gene ID: 300160 | Gene type: protein coding

About Lrrk2

Primary_assembly 7: 122,826,696-122,987,703 forward strand.mRatBN7.2:CM026980.1

This gene has 2 transcripts (splice variants), 191 orthologues, 23 paralogues and is associated with 52 phenotypes. Biased expression in Lung (RPKM 24.9), Spleen (RPKM 172.7) and 8 other tissues.

Summary

Predicted to enable several functions, including GTP binding activity; cytoskeletal protein binding activity; and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of macromolecule metabolic process; and positive regulation of microglial cell activation. Located in several cellular components, including axon; dendrite; and perikaryon. Used to study neurodegenerative disease. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Crohn's disease; Parkinson's disease; Parkinson's disease 8; Parkinsonism; and Cancer. Orthologous to human LRRK2 (leucine rich repeat kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk2 Products(1)

mRNA	Protein	Name
NM_001191789.2	NP_001178718.2	leucine-rich repeat serine/threonine-protein kinase 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19879924	RGD
involved in negative regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17114044	RGD
involved in neuron projection arborization	IMP IMP: Inferred from mutant phenotype	17114044	RGD
involved in positive regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	22302802	RGD
involved in positive regulation of nitric-oxide synthase biosynthetic process	IMP IMP: Inferred from mutant phenotype	22302802	RGD
involved in positive regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	18445495	RGD
involved in positive regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	22302802	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	20403420	RGD
involved in striatum development	IEP IEP: Inferred from expression pattern	18272292	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	17114044	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17114044	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18445495	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17114044	RGD
is active in presynaptic cytosol	IDA IDA: Inferred from direct assay	18445495	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lrrk2 Protein Structure

LRR_RI

PRK15370

LRR_RI

RocCOR

COR

STKc_LRRK2

0
400
800
1200
1600
2000
2400
2526 a.a.

Protein Preferred Names

Protein Names

leucine-rich repeat serine/threonine-protein kinase 2

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-112809	GSK2646264	Inhibitor	98.39%	Phase 1

Pre-clinical Phase

Bioactive Molecules (44)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100411	MLi-2	Inhibitor	99.80%	Unkown
HY-13687	IKK 16	Inhibitor	99.88%	Unkown
HY-10875	LRRK2-IN-1	Inhibitor	99.42%	Unkown
HY-12477	PF-06447475	Inhibitor	99.94%	Unkown
HY-15796	GNE0877	Inhibitor	99.81%	Unkown
HY-148030	XL01126	Inhibitor	98.65%	Unkown
HY-18163	GNE-7915	Inhibitor	99.82%	Unkown
HY-13237	GSK2578215A	Inhibitor	99.78%	Unkown
HY-40294	Indazole	Inhibitor	99.72%	Unkown
HY-13488	HG-10-102-01	Inhibitor	99.55%	Unkown
HY-120085	PFE-360	Inhibitor	99.48%	Unkown
HY-13687A	IKK 16 hydrochloride	Inhibitor	99.95%	Unkown
HY-15800A	CZC-25146	Inhibitor	99.10%	Unkown
HY-12282	GNE-9605	Inhibitor	99.72%	Unkown
HY-B0792	CZC-54252	Inhibitor	99.38%	Unkown
HY-163064	CC-3240	Degrader	98.23%	Unkown
HY-16936	JH-II-127	Inhibitor	≥98.0%	Unkown
HY-142647	EB-42486	Inhibitor	99.62%	Unkown
HY-152107	LRRK2-IN-7	Inhibitor	98.04%	Unkown
HY-112855	PF-06454589	Inhibitor	99.91%	Unkown
HY-156429	MK-1468	Inhibitor	99.69%	Unkown
HY-111493	LRRK2 inhibitor 1	Inhibitor	99.93%	Unkown
HY-155150	JH-XII-03-02	Inhibitor	99.41%	Unkown
HY-18163A	GNE-7915 tosylate	Inhibitor	99.06%	Unkown
HY-145317	LRRK2-IN-2	Inhibitor	/	Unkown
HY-151444	LRRK2-IN-6	Inhibitor	/	Unkown
HY-151441	LRRK2-IN-5	Inhibitor	/	Unkown
HY-153058	LRRK2-IN-8	Inhibitor	/	Unkown
HY-153103	LRRK2/NUAK1/TYK2-IN-1	Inhibitor	/	Unkown
HY-148353	PF-06455943	Inhibitor	/	Unkown
HY-162699	LY2023-001	Inhibitor	/	Unkown
HY-134562	PF-06371900	Inhibitor	/	Unkown
HY-144074	LRRK2-IN-4	Inhibitor	/	Unkown
HY-168041	LRRK2-IN-15	Inhibitor	/	Unkown
HY-152107A	(R,R)-LRRK2-IN-7	Inhibitor	/	Unkown
HY-169576	LRRK2-IN-16	Inhibitor	/	Unkown
HY-161570	LRRK2-IN-12	Inhibitor	/	Unkown
HY-145318	LRRK2-IN-3	Inhibitor	/	Unkown
HY-B0792A	CZC-54252 hydrochloride	Inhibitor	98.44%	Unkown
HY-161571	LRRK2-IN-13	Inhibitor	/	Unkown
HY-156167	LRRK2-IN-10	Inhibitor	/	Unkown
HY-158365	LRRK2-IN-14	Inhibitor	/	Unkown
HY-15800	CZC-25146 hydrochloride	Inhibitor	/	Unkown
HY-P10636	Nictide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lrrk2	NCBI	NCBI:120892

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