DDX21 - DExD-box helicase 21 Gene

Homo sapiens

Also known as RH; GUA; GURDB; II/Gu; RH II/Gu; RH-II/GU; gu-alpha; RH-II/GuA

Gene ID: 9188 | Gene type: protein coding

About DDX21

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:68,956,170-68,985,068 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues and 38 paralogues. Ubiquitous expression in bone marrow (RPKM 38.2), appendix (RPKM 33.3) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune Antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

DDX21 Products(3)

mRNA	Protein	Name
NM_001256910.2	NP_001243839.1	nucleolar RNA helicase 2 isoform 2
NM_001410932.1	NP_001397861.1	nucleolar RNA helicase 2 isoform 3
NM_004728.4	NP_004719.2	nucleolar RNA helicase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	25470060	GOA
enables RNA helicase activity	IDA IDA: Inferred from direct assay	9461305	GOA
enables RNA helicase activity	IMP IMP: Inferred from mutant phenotype	25470060	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	28431233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15034300	GOA
enables rRNA binding	IDA IDA: Inferred from direct assay	25470060	GOA
enables snoRNA binding	IDA IDA: Inferred from direct assay	25470060	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in R-loop processing	IDA IDA: Inferred from direct assay	28790157	GOA
involved in positive regulation of transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	16603771	GOA
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25470060	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of B-WICH complex	IDA IDA: Inferred from direct assay	16603771	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	28790157	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	28790157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX21 Protein Structure

DEAD

Helicase_C

GUCT

0
200
400
600
783 a.a.

Protein Preferred Names

Protein Names

nucleolar RNA helicase 2

DEAD (Asp-Glu-Ala-Asp) box helicase 21

DDX21 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDX21	Q9NR30	CDK9	Homo sapiens	P50750	Anti Bait CoIP	25470060
Intra	DDX21	Q9NR30	CDK9	Homo sapiens	P50750	Anti Tag CoIP	35271311
Intra	DDX21	Q9NR30	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	33961781
Intra	DDX21	Q9NR30	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	25470060
Intra	DDX21	Q9NR30	LARP7	Homo sapiens	Q4G0J3	Anti Tag CoIP	35271311
Cross	DDX21	Q9NR30	N	SARS-CoV-2	P0DTC9	Anti Bait CoIP	35107372
Cross	DDX21	Q9NR30	N	SARS-CoV-2	P0DTC9	Confocal	35107372
Intra	DDX21	Q9NR30	HNRNPA1	Homo sapiens	P09651	Anti Tag CoIP	35271311
Intra	DDX21	Q9NR30	HNRNPC	Homo sapiens	P07910	Crosslink	30021884
Intra	DDX21	Q9NR30	HNRNPC	Homo sapiens	P07910	Anti Tag CoIP	35271311
Intra	DDX21	Q9NR30	HNRNPC	Homo sapiens	P07910	Chromatography	15034300
Intra	DDX21	Q9NR30	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	33961781
Intra	DDX21	Q9NR30	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	25416956
Intra	DDX21	Q9NR30	KPNA3	Homo sapiens	O00505	Validated Y2H	25416956
Intra	DDX21	Q9NR30	KPNA3	Homo sapiens	O00505	Y2H Array	25416956
Intra	DDX21	Q9NR30	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	35271311
Intra	DDX21	Q9NR30	H1-2	Homo sapiens	P16403	Crosslink	30021884
Intra	DDX21	Q9NR30	MAPT	Homo sapiens	P10636	Y2H Pooling	32814053
Intra	DDX21	Q9NR30	MAPT	Homo sapiens	P10636	Validated Y2H	32814053
Intra	DDX21	Q9NR30	MAPT	Homo sapiens	P10636	Y2H Array	32814053
Intra	DDX21	Q9NR30	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	33961781
Intra	DDX21	Q9NR30	SRPK2	Homo sapiens	P78362	BiFC	23602568
Intra	DDX21	Q9NR30	TERF2	Homo sapiens	Q15554	Pull Down	21044950
Intra	DDX21	Q9NR30	LITAF	Homo sapiens	Q99732	Validated Y2H	32814053
Intra	DDX21	Q9NR30	LITAF	Homo sapiens	Q99732	Y2H Array	32814053
Intra	DDX21	Q9NR30	LITAF	Homo sapiens	Q99732	Y2H Pooling	32814053
Intra	DDX21	Q9NR30	CARF	Homo sapiens	Q8N187	Y2H Array	32814053
Intra	DDX21	Q9NR30	CARF	Homo sapiens	Q8N187	Y2H Pooling	32814053
Intra	DDX21	Q9NR30	CARF	Homo sapiens	Q8N187	Validated Y2H	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Stomach Disease

Gastropathy	Stomach Diseases
Gastric Disease	Stomach Disorder
Gastric Disorder	Stomach Disorders

Gastric Antral Vascular Ectasia

Watermelon Stomach

Gave

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03637	DDX21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DDX21	VGNC	VGNC:39849
Mus musculus	DDX21	MGD	MGI:1860494
Bos taurus	DDX21	VGNC	VGNC:97259
Rattus norvegicus	DDX21	RGD	RGD:1307306

Name
Email *

	Sorry, but the email address you supplied was invalid.