DDX21 - DExD-box helicase 21 Gene

Homo sapiens

Also known as RH; GUA; GURDB; II/Gu; RH II/Gu; RH-II/GU; gu-alpha; RH-II/GuA

Gene ID: 9188 | Gene type: protein coding

About DDX21

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:68,956,170-68,985,068 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues and 38 paralogues. Ubiquitous expression in bone marrow (RPKM 38.2), appendix (RPKM 33.3) and 25 other tissues.

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune Antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

DDX21 Products(3)

mRNA	Protein	Name
NM_001256910.2	NP_001243839.1	nucleolar RNA helicase 2 isoform 2
NM_001410932.1	NP_001397861.1	nucleolar RNA helicase 2 isoform 3
NM_004728.4	NP_004719.2	nucleolar RNA helicase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 7SK snRNA binding	IDA IDA: Inferred from direct assay	25470060	GOA
enables RNA helicase activity	IDA IDA: Inferred from direct assay	9461305	GOA
enables RNA helicase activity	IMP IMP: Inferred from mutant phenotype	25470060	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	28431233	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15034300	GOA
enables rRNA binding	IDA IDA: Inferred from direct assay	25470060	GOA
enables snoRNA binding	IDA IDA: Inferred from direct assay	25470060	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in R-loop processing	IDA IDA: Inferred from direct assay	28790157	GOA
involved in positive regulation of transcription by RNA polymerase III	IDA IDA: Inferred from direct assay	16603771	GOA
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25470060	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of B-WICH complex	IDA IDA: Inferred from direct assay	16603771	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	28790157	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	28790157	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX21 Protein Structure

DEAD

Helicase_C

GUCT

0
200
400
600
783 a.a.

Protein Preferred Names

Protein Names

nucleolar RNA helicase 2

DEAD (Asp-Glu-Ala-Asp) box helicase 21

Related Diseases

Diseases

Alias

Stomach Disease

Gastropathy	Stomach Diseases
Gastric Disease	Stomach Disorder
Gastric Disorder	Stomach Disorders

Gastric Antral Vascular Ectasia

Watermelon Stomach

Gave

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03637	DDX21 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DDX21	VGNC	VGNC:39849
Mus musculus	DDX21	MGD	MGI:1860494
Bos taurus	DDX21	VGNC	VGNC:97259
Rattus norvegicus	DDX21	RGD	RGD:1307306

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