2. Gene
  3. HOXC5 - homeobox C5 Gene

HOXC5 - homeobox C5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CP11; HOX3; HOX3D

Gene ID: 3222 | Gene type: protein coding

About HOXC5

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,016,888-54,035,361 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 42 paralogues. Biased expression in ovary (RPKM 1.6), kidney (RPKM 1.3) and 12 other tissues.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC5, is one of several homeobox HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Two alternatively spliced variants have been described for HOXC5. The transcript variant which includes the shared exon apparently doesn't encode a protein. The protein-coding transcript variant contains gene-specific exons only. [provided by RefSeq, Jul 2008]

HOXC5 Products(1)

mRNA Protein Name
NM_018953.4 NP_061826.1 homeobox protein Hox-C5
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HOXC5 Protein Structure

Homeobox

Homeobox: Homeobox domain (156 - 212)

  • 0
  • 100
  • 200
  • 222 a.a.
Protein Preferred Names Protein Names

homeobox protein Hox-C5

homeo box C5

HOXC5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra HOXC5 Q00444 CTBP2 Homo sapiens P56545-3
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 CTBP2 Homo sapiens P56545-3
Y2H Array
32296183
Intra HOXC5 Q00444 PBX4 Homo sapiens Q9BYU1
Y2H Array
32296183
Intra HOXC5 Q00444 PBX4 Homo sapiens Q9BYU1
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 PBX4 Homo sapiens Q9BYU1
Validated Y2H
32296183
Intra HOXC5 Q00444 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra HOXC5 Q00444 LHX3 Homo sapiens Q9UBR4-2
Validated Y2H
32296183
Intra HOXC5 Q00444 LHX3 Homo sapiens Q9UBR4-2
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 LHX3 Homo sapiens Q9UBR4-2
Y2H Array
32296183
Intra HOXC5 Q00444 LHX4 Homo sapiens Q969G2
Validated Y2H
32296183
Intra HOXC5 Q00444 LHX4 Homo sapiens Q969G2
Y2H Array
32296183
Intra HOXC5 Q00444 LHX4 Homo sapiens Q969G2
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 PBX1 Homo sapiens P40424
Y2H Array
32296183
Intra HOXC5 Q00444 PBX1 Homo sapiens P40424
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 POLR2G Homo sapiens P62487
Y2H Array
32296183
Intra HOXC5 Q00444 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 POLR2G Homo sapiens P62487
MAPPIT
32296183
Intra HOXC5 Q00444 PBX2 Homo sapiens P40425
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 PBX2 Homo sapiens P40425
Y2H Array
32296183
Intra HOXC5 Q00444 ZBTB16 Homo sapiens Q05516
Y2H Array
32296183
Intra HOXC5 Q00444 ZBTB16 Homo sapiens Q05516
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 ZBTB16 Homo sapiens Q05516
Validated Y2H
32296183
Intra HOXC5 Q00444 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra HOXC5 Q00444 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra HOXC5 Q00444 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 DVL3 Homo sapiens Q92997
Y2H Prey Pooling
32296183
Intra HOXC5 Q00444 DVL3 Homo sapiens Q92997
Y2H Array
32296183
Intra HOXC5 Q00444 DVL3 Homo sapiens Q92997
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06318 HOXC5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HOXC5 RGD RGD:1307584
Bos taurus HOXC5 VGNC VGNC:56208
Mus musculus HOXC5 MGD MGI:96196