AQP8 - aquaporin 8 Gene

Homo sapiens

Also known as AQP-8

Gene ID: 343 | Gene type: protein coding

About AQP8

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:25,216,947-25,228,932 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 11 paralogues. Restricted expression toward colon (RPKM 257.9).

Summary

Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]

AQP8 Products(1)

mRNA	Protein	Name
NM_001169.3	NP_001160.2	aquaporin-8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables methylammonium channel activity	IDA IDA: Inferred from direct assay	15948717	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables water channel activity	IDA IDA: Inferred from direct assay	15948717	GOA
enables water channel activity	IMP IMP: Inferred from mutant phenotype	18948439	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ammonium transmembrane transport	IMP IMP: Inferred from mutant phenotype	22622463	GOA
involved in cellular detoxification	IMP IMP: Inferred from mutant phenotype	34292591	GOA
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	17636236	GOA
involved in hydrogen peroxide transmembrane transport	IMP IMP: Inferred from mutant phenotype	23541115	GOA
involved in methylammonium transport	IDA IDA: Inferred from direct assay	15948717	GOA
involved in regulation of cholesterol biosynthetic process	IMP IMP: Inferred from mutant phenotype	30579780	GOA
involved in water transport	IDA IDA: Inferred from direct assay	15948717	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	12801959	GOA
located in intracellular canaliculus	IDA IDA: Inferred from direct assay	18948439	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	22622463	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP8 Protein Structure

MIP

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

aquaporin-8

Related Diseases

Diseases

Alias

Polyhydramnios

Palmoplantar Keratoderma, Bothnian Type

PPKB	Diffuse Palmoplantar Keratoderma, Bothnian Type
Bothnian Type Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Bothnian Type
Palmoplantar Keratoderma, Nonepidermolytic

Crohn'S Colitis

Crohn Disease

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Oligohydramnios

Oligohydramnios - Delivered	Antepartum Oligohydramnios
Delivered Oligohydramnios	Oligohydramnios, Antepartum Condition Or Complication
Deficient Liquor	Oligohydramnios, Unspecified Trimester
Reduced Liquor Volume

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00880	AQP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AQP8	VGNC	VGNC:38020
Felis catus	AQP8	VGNC	VGNC:67985
Macaca mulatta	AQP8	VGNC	VGNC:69995
Bos taurus	AQP8	VGNC	VGNC:26050
Mus musculus	AQP8	MGD	MGI:1195271
Rattus norvegicus	AQP8	RGD	RGD:2146

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