STX12 - syntaxin 12 Gene

Homo sapiens

Also known as STX13; STX14

Gene ID: 23673 | Gene type: protein coding

About STX12

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:27,773,219-27,824,443 (from NCBI)

This gene has 5 transcripts (splice variants), 248 orthologues and 12 paralogues. Ubiquitous expression in thyroid (RPKM 63.8), fat (RPKM 35.7) and 25 other tissues.

Summary

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in autophagosome assembly; Cholesterol efflux; and protein stabilization. Located in several cellular components, including membrane raft; phagocytic vesicle; and phagophore assembly site. Part of SNARE complex. Colocalizes with BLOC-1 complex. [provided by Alliance of Genome Resources, Apr 2022]

STX12 Products(1)

mRNA	Protein	Name
NM_177424.3	NP_803173.1	syntaxin-12

STX12 Protein Structure

Syntaxin_2

SNARE

0
100
200
276 a.a.

Protein Preferred Names

Protein Names

syntaxin-12

STX12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	STX12	Q86Y82	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	33961781
Intra	STX12	Q86Y82	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	28514442
Intra	STX12	Q86Y82	SNAP47	Homo sapiens	Q5SQN1	Anti Tag CoIP	26359495
Intra	STX12	Q86Y82	CISD2	Homo sapiens	Q8N5K1	Validated Y2H	32296183
Intra	STX12	Q86Y82	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	STX12	Q86Y82	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	NEMP1	Homo sapiens	O14524-2	Y2H Array	32296183
Intra	STX12	Q86Y82	NEMP1	Homo sapiens	O14524-2	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	STXBP5L	Homo sapiens	Q9Y2K9	Validated Y2H	32296183
Intra	STX12	Q86Y82	STXBP5L	Homo sapiens	Q9Y2K9	Y2H Array	32296183
Intra	STX12	Q86Y82	STXBP5L	Homo sapiens	Q9Y2K9	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	STX2	Homo sapiens	P32856-2	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	STX2	Homo sapiens	P32856-2	Y2H Array	32296183
Intra	STX12	Q86Y82	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	RIC3	Homo sapiens	Q7Z5B4-5	Y2H Array	32296183
Intra	STX12	Q86Y82	TLCD4	Homo sapiens	Q96MV1	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	TLCD4	Homo sapiens	Q96MV1	Validated Y2H	32296183
Intra	STX12	Q86Y82	TLCD4	Homo sapiens	Q96MV1	Y2H Array	32296183
Intra	STX12	Q86Y82	PLPPR2	Homo sapiens	Q96GM1	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	PLPPR2	Homo sapiens	Q96GM1	Validated Y2H	32296183
Intra	STX12	Q86Y82	PLPPR2	Homo sapiens	Q96GM1	Y2H Array	32296183
Intra	STX12	Q86Y82	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	STX12	Q86Y82	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	TMEM167B	Homo sapiens	Q9NRX6	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	TMEM167B	Homo sapiens	Q9NRX6	Y2H Array	32296183
Intra	STX12	Q86Y82	TMEM167B	Homo sapiens	Q9NRX6	Validated Y2H	32296183
Intra	STX12	Q86Y82	SLC10A6	Homo sapiens	Q3KNW5	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	SLC10A6	Homo sapiens	Q3KNW5	Y2H Array	32296183
Intra	STX12	Q86Y82	AQP8	Homo sapiens	O94778	Y2H Array	32296183
Intra	STX12	Q86Y82	AQP8	Homo sapiens	O94778	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	TMEM86B	Homo sapiens	Q8N661	Y2H Array	32296183
Intra	STX12	Q86Y82	TMEM86B	Homo sapiens	Q8N661	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	TMEM86B	Homo sapiens	Q8N661	Validated Y2H	32296183
Intra	STX12	Q86Y82	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	SEC11C	Homo sapiens	Q9BY50	Validated Y2H	32296183
Intra	STX12	Q86Y82	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183
Intra	STX12	Q86Y82	MFSD6	Homo sapiens	Q6ZSS7	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	MFSD6	Homo sapiens	Q6ZSS7	Y2H Array	32296183
Intra	STX12	Q86Y82	SLC66A2	Homo sapiens	Q8N2U9	Validated Y2H	32296183
Intra	STX12	Q86Y82	SLC66A2	Homo sapiens	Q8N2U9	Y2H Array	32296183
Intra	STX12	Q86Y82	SLC66A2	Homo sapiens	Q8N2U9	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	EBP	Homo sapiens	Q15125	Y2H Array	32296183
Intra	STX12	Q86Y82	EBP	Homo sapiens	Q15125	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	GORAB	Homo sapiens	Q5T7V8	Y2H Array	32296183
Intra	STX12	Q86Y82	GORAB	Homo sapiens	Q5T7V8	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	SNAP29	Homo sapiens	O95721	Validated Y2H	25416956
Intra	STX12	Q86Y82	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	33961781
Intra	STX12	Q86Y82	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	28514442
Intra	STX12	Q86Y82	SNAP29	Homo sapiens	O95721	Y2H Array	25416956
Intra	STX12	Q86Y82	SNAP29	Homo sapiens	O95721	Y2H Prey Pooling	25416956
Intra	STX12	Q86Y82	SNAP29	Homo sapiens	O95721	Anti Tag CoIP	35271311
Intra	STX12	Q86Y82	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
Intra	STX12	Q86Y82	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
Intra	STX12	Q86Y82	TIMMDC1	Homo sapiens	Q9NPL8	Validated Y2H	32296183
Intra	STX12	Q86Y82	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	TIMMDC1	Homo sapiens	Q9NPL8	Y2H Array	32296183
Intra	STX12	Q86Y82	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	STX12	Q86Y82	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	STX12	Q86Y82	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	STX12	Q86Y82	PDZK1IP1	Homo sapiens	Q13113	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	PDZK1IP1	Homo sapiens	Q13113	Y2H Array	32296183
Intra	STX12	Q86Y82	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	25416956
Intra	STX12	Q86Y82	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
Intra	STX12	Q86Y82	STX4	Homo sapiens	Q12846	Anti Tag CoIP	28514442
Intra	STX12	Q86Y82	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	25416956
Intra	STX12	Q86Y82	STX4	Homo sapiens	Q12846	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	STX4	Homo sapiens	Q12846	Y2H Array	32296183
Intra	STX12	Q86Y82	STX4	Homo sapiens	Q12846	Anti Tag CoIP	33961781
Intra	STX12	Q86Y82	BCL2L13	Homo sapiens	Q9BXK5	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	BCL2L13	Homo sapiens	Q9BXK5	Y2H Array	32296183
Intra	STX12	Q86Y82	BCL2L13	Homo sapiens	Q9BXK5	Validated Y2H	32296183
Intra	STX12	Q86Y82	KASH5	Homo sapiens	Q8N6L0	Validated Y2H	32296183
Intra	STX12	Q86Y82	KASH5	Homo sapiens	Q8N6L0	Y2H Array	32296183
Intra	STX12	Q86Y82	KASH5	Homo sapiens	Q8N6L0	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	LEPROTL1	Homo sapiens	O95214	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	LEPROTL1	Homo sapiens	O95214	Y2H Array	32296183
Intra	STX12	Q86Y82	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	STX12	Q86Y82	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	STX12	Q86Y82	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183
Intra	STX12	Q86Y82	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	STX12	Q86Y82	ABCA1	Homo sapiens	O95477	IF	15469992
Intra	STX12	Q86Y82	ABCA1	Homo sapiens	O95477	Anti Bait CoIP	15469992
Intra	STX12	Q86Y82	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	STX12	Q86Y82	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	STX12	Q86Y82	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Xia-Gibbs Syndrome

Ahdc1-Related Intellectual Disability-Obstructive Sleep Apnea-Mild Dysmorphism Syndrome	XIGIS
Mrd25	Ahdc1-Related Intellectual Disability - Obstructive Sleep Apnea - Mild Dysmorphism Syndrome
Mental Retardation, Autosomal Dominant 25, Formerly	Mrd25, Formerly
Autosomal Dominant Mental Retardation 25	Autosomal Dominant Intellectual Disability 25
Xgs

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13976	STX12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	STX12	VGNC	VGNC:65807
Canis familiaris	STX12	VGNC	VGNC:84434
Rattus norvegicus	STX12	RGD	RGD:620977
Bos taurus	STX12	VGNC	VGNC:35432
Mus musculus	STX12	MGD	MGI:1931027

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