LDHB - lactate dehydrogenase B Gene

Homo sapiens

Also known as LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281

Gene ID: 3945 | Gene type: protein coding

About LDHB

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,635,342-21,657,842 (from NCBI)

This gene has 11 transcripts (splice variants), 279 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 475.5), heart (RPKM 454.7) and 21 other tissues.

Summary

This gene encodes the B subunit of Lactate Dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with Lactate Dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]

LDHB Products(6)

mRNA	Protein	Name
NM_001174097.3	NP_001167568.1	L-lactate dehydrogenase B chain isoform LDHB
NM_001315537.2	NP_001302466.1	L-lactate dehydrogenase B chain isoform LDHBx
NM_001414233.1	NP_001401162.1	L-lactate dehydrogenase B chain isoform 3
NM_001414234.1	NP_001401163.1	L-lactate dehydrogenase B chain isoform 4
NM_001414235.1	NP_001401164.1	L-lactate dehydrogenase B chain isoform 5
NM_002300.8	NP_002291.1	L-lactate dehydrogenase B chain isoform LDHB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables L-lactate dehydrogenase activity	IDA IDA: Inferred from direct assay	27618187	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in lactate metabolic process	IDA IDA: Inferred from direct assay	15117937	GOA
involved in pyruvate metabolic process	IDA IDA: Inferred from direct assay	15117937	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane raft	IDA IDA: Inferred from direct assay	25204797	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	27618187	GOA
part of oxidoreductase complex	IPI IPI: Inferred from physical interaction	15117937	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDHB Protein Structure

Ldh_1_N

Ldh_1_C

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

L-lactate dehydrogenase B chain

LDH heart subunit

LDHB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Array	25416956
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Array	32296183
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Prey Pooling	32296183
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Validated Y2H	25910212
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Bait-Prey Pool	25910212
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338-3	Y2H Array	25910212
Intra	LDHB	P07195	LDHC	Homo sapiens	P07864	Anti Tag CoIP	33961781
Intra	LDHB	P07195	LDHC	Homo sapiens	P07864	Anti Tag CoIP	28514442
Intra	LDHB	P07195	LDHC	Homo sapiens	P07864	Anti Tag CoIP	35271311
Intra	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Prey Pooling	32296183
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338	Anti Tag CoIP	33961781
Intra	LDHB	P07195	LDHB	Homo sapiens	P07195	Validated Y2H	32296183
Intra	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	25416956
Intra	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	25502805
Intra	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	32296183
Intra	LDHB	P07195	LDHA	Homo sapiens	P00338	Anti Tag CoIP	35271311
Intra	LDHB	P07195	LDHB	Homo sapiens	P07195	Y2H Array	31515488
Intra	LDHB	P07195	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	LDHB	P07195	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	LDHB	P07195	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	LDHB	P07195	PEX5	Homo sapiens	P50542	Validated Y2H	25416956
Intra	LDHB	P07195	PEX5	Homo sapiens	P50542	Y2H Array	25416956
Intra	LDHB	P07195	TERF1	Homo sapiens	P54274	BiFC	21044950
Intra	LDHB	P07195	TERF1	Homo sapiens	P54274	Pull Down	21044950
Intra	LDHB	P07195	SDCBP	Homo sapiens	O00560	Y2H Array	32296183
Intra	LDHB	P07195	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LDHB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70265	LDHB Protein, Human (His)	P07195 (M1-L334)	≥95%

Related Diseases

Diseases

Alias

Lactate Dehydrogenase B Deficiency

LDHBD	Glycogen Storage Disease Due To Lactate Dehydrogenase H-Subunit Deficiency
Lactate Dehydrogenase-B Deficiency	Ldh Deficiency B
Lactate Dehydrogenase Deficiency Type B	Gsd Due To Lactate Dehydrogenase H-Subunit Deficiency
Glycogenosis Due To Lactate Dehydrogenase H-Subunit Deficiency	Ldh-H Subunit Deficiency

Maxillary Sinus Cancer

Malignant Neoplasm Of Antrum	Malignant Tumor Of The Maxillary Sinus
Maxillary Sinus Carcinoma	Cancer Of Maxillary Sinus
Maxillary Sinus Neoplasms

Maxillary Sinus Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Maxillofacial Sinus

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa 8, Formerly	Rp8, Formerly
Retinitis Pigmentosa 21, Formerly	Rp21, Formerly
Usher Syndrome

Alzheimer Disease 13

AD13	Alzheimer Disease-13
Alzheimer'S Disease 13	Alzheimer'S Disease 13, Late Onset

Parkinson Disease 17

PARK17	Parkinson'S Disease 17
Autosomal Dominant Parkinson Disease 17	Parkinson Disease, Type 17

Paranasal Sinus Cancer

Paranasal Sinus Adenoid Cystic Carcinoma	Paranasal Sinus Mucoepidermoid Carcinoma
Paranasal Sinus Squamous Cell Carcinoma	Paranasal Sinus Neoplasms
Adenoid Cystic Carcinoma Of Accessory Sinus	Adenoid Cystic Carcinoma Of Paranasal Sinus
Epidermoid Carcinoma Of The Paranasal Sinus	Mucoepidermoid Carcinoma Of Accessory Sinus
Paranasal Sinus Adenocarcinoma	Squamous Cell Carcinoma Of Paranasal Sinus
Paranasal Sinus Neoplasm	Adenocarcinoma Of Accessory Sinus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100742A	(R)-GNE-140	Inhibitor	99.73%	Unkown
HY-W040118	Galloflavin	Inhibitor	99.36%	Unkown
HY-147216	AXKO-0046	Inhibitor	99.64%	Unkown
HY-111108	LDH-IN-1	Inhibitor	99.86%	Unkown
HY-147216A	AXKO-0046 dihydrochloride	Inhibitor	99.68%	Unkown
HY-152261	MS6105		/	Unkown
HY-162629	LDHA-IN-7	Inhibitor	/	Unkown
HY-RS07572	LDHB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LDHB	VGNC	VGNC:30824
Mus musculus	LDHB	MGD	MGI:96763
Rattus norvegicus	LDHB	RGD	RGD:2997
Others	LDHB	NCBI

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