ARL2 - ADP ribosylation factor like GTPase 2 Gene

Homo sapiens

Also known as ARFL2; MRCS1

Gene ID: 402 | Gene type: protein coding

About ARL2

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,014,160-65,022,184 (from NCBI)

This gene has 6 transcripts (splice variants), 188 orthologues, 30 paralogues and is associated with 2 phenotypes. Ubiquitous expression in kidney (RPKM 49.3), fat (RPKM 49.1) and 25 other tissues.

Summary

This gene encodes a small GTP-binding protein of the Ras superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

ARL2 Products(2)

mRNA	Protein	Name
NM_001199745.2	NP_001186674.1	ADP-ribosylation factor-like protein 2 isoform 2
NM_001667.4	NP_001658.2	ADP-ribosylation factor-like protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IMP IMP: Inferred from mutant phenotype	10831612	GOA
enables GTPase activity	IMP IMP: Inferred from mutant phenotype	10831612	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10831612	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	16525022	GOA
involved in maintenance of protein location in nucleus	IDA IDA: Inferred from direct assay	18234692	GOA
involved in negative regulation of GTPase activity	IDA IDA: Inferred from direct assay	10831612	GOA
involved in positive regulation of microtubule polymerization	IDA IDA: Inferred from direct assay	10831612	GOA
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	30945270	GOA
involved in regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	30945270	GOA
involved in regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	16525022	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	16525022	GOA
NOT located in cilium	IDA IDA: Inferred from direct assay	17646400	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	11809823	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	30945270	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18234692	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL2 Protein Structure

Arf

0
100
184 a.a.

Protein Preferred Names

Protein Names

ADP-ribosylation factor-like protein 2

ADP-ribosylation factor-like 2

Related Diseases

Diseases

Alias

Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 1

MRCS1

Cone Dystrophy

Retinal Cone Dystrophy	Dystrophy, Cone
Cone Dystrophy 3

Retinitis Pigmentosa 2

RP2	X-Linked Retinitis Pigmentosa 2
Xlrp2	Xlrp-2
Retinitis Pigmentosa-2	Retinitis Pigmentosa, Type 2

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Retinitis Pigmentosa 3

RP3	Retinitis Pigmentosa 15
Rp15	Choroidoretinal Degeneration With Retinal Reflex In Heterozygous Women
Cone-Rod Degeneration, X-Linked	Retinitis Pigmentosa Type 15
X-Linked Cone-Rod Degeneration	X-Linked Retinitis Pigmentosa 3
Xlrp3	Xlrp-3
Retinitis Pigmentosa-3	Retinitis Pigmentosa, Type 3

Hypoparathyroidism-Retardation-Dysmorphism Syndrome

Sanjad-Sakati Syndrome	Hrd Syndrome
HRDS	Hypoparathyroidism-Intellectual Disability-Dysmorphism Syndrome
Hypoparathyroidism-Short Stature-Intellectual Disability-Seizures Syndrome	Richardson-Kirk Syndrome
Sss	Hypoparathyroidism With Short Stature, Mental Retardation, And Seizures
Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation, And Developmental Delay	Hypoparathyroidism With Short Stature, Mental Retardation And Seizures
Hypoparathyroidism With Short Stature, Intellectual Disability And Seizures	Hypoparathyroidism, Congenital, Associated With Dysmorphism, Growth Retardation And Developmental Delay

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122641	Deltasonamide 1	Inhibitor	99.15%	Unkown
HY-122641D	Deltasonamide 1 TFA	Inhibitor	99.70%	Unkown
HY-RS00985	ARL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00986	ARL2BP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ARL2	MGD	MGI:1928393
Rattus norvegicus	ARL2	RGD	RGD:69326
Macaca mulatta	ARL2	VGNC	VGNC:99549
Bos taurus	ARL2	VGNC	VGNC:97240
Others	ARL2	NCBI

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