MAGOH - mago homolog, exon junction complex subunit Gene

Homo sapiens

Also known as MAGOH1; MAGOHA

Gene ID: 4116 | Gene type: protein coding

About MAGOH

Cytogenetic location: 1p32.3 Genomic coordinates (GRCh38): 1:53,226,900-53,238,518 (from NCBI)

This gene has 4 transcripts (splice variants), 215 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 28.8), colon (RPKM 24.3) and 25 other tissues.

Summary

Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

MAGOH Products(1)

mRNA	Protein	Name
NM_002370.4	NP_002361.1	protein mago nashi homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10662555	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IGI IGI: Inferred from genetic interaction	23917022	GOA
involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IMP IMP: Inferred from mutant phenotype	16209946	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IMP IMP: Inferred from mutant phenotype	22203037	GOA
involved in regulation of mRNA processing	IDA IDA: Inferred from direct assay	23115303	GOA
involved in regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IDA IDA: Inferred from direct assay	19478851	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
part of exon-exon junction complex	IDA IDA: Inferred from direct assay	16601204	GOA
part of exon-exon junction complex	IPI IPI: Inferred from physical interaction	16931718	GOA
part of exon-exon junction subcomplex mago-y14	IPI IPI: Inferred from physical interaction	12781131	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22720776	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGOH Protein Structure

Mago_nashi

0
100
146 a.a.

Protein Preferred Names

Protein Names

protein mago nashi homolog

mago homolog, exon junction complex core component

Recombinant MAGOH Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76484	MAGOH Protein, Human (His)	P61326-1/NP_002361.1 (M1-I146)	≥95%

Related Diseases

Diseases

Alias

Metaphyseal Chondrodysplasia, Schmid Type

MCDS	Schmid Metaphyseal Chondrodysplasia
Metaphyseal Chondrodysplasia Schmid Type	Spondylometaphyseal Dysplasia, Japanese Type
Japanese Type Spondylometaphyseal Dysplasia	Schmid Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia Type Schmid	Schmid Type Metaphyseal Chondrodysplasia
SMCD	Chondrodysplasia, Metaphyseal, Schmid Type
Corneal Dystrophy, Subepithelial Mucinous

Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07985	MAGOH Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAGOH	VGNC	VGNC:107580
Rattus norvegicus	MAGOH	RGD	RGD:1305174
Mus musculus	MAGOH	MGD	MGI:1330312
Others	MAGOH	NCBI

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