2. Gene
  3. DRG1 - developmentally regulated GTP binding protein 1 Gene

DRG1 - developmentally regulated GTP binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NEDD3

Gene ID: 4733 | Gene type: protein coding

About DRG1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,399,604-31,434,452 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 4 paralogues. Broad expression in testis (RPKM 112.9), thyroid (RPKM 23.8) and 24 other tissues.

Summary

Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]

DRG1 Products(1)

mRNA Protein Name
NM_004147.4 NP_004138.1 developmentally-regulated GTP-binding protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activity IDA
IDA: Inferred from direct assay
23711155 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
23711155 GOA
enables microtubule binding IDA
IDA: Inferred from direct assay
28855639 GOA
enables potassium ion binding IDA
IDA: Inferred from direct assay
23711155 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
28855639 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
28855639 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19819225 GOA
located in nucleus IDA
IDA: Inferred from direct assay
29915238 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DRG1 Protein Structure

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (66 - 165)

TGS

TGS: TGS domain (292 - 366)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

developmentally-regulated GTP-binding protein 1

DRG-1

DRG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Anti Tag CoIP
28514442
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Array
25416956
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Array
32296183
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Prey Pooling
25416956
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Anti Tag CoIP
35271311
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H Prey Pooling
32296183
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Y2H
21516116
Intra
DRG1 Q9Y295 ZC3H15 Homo sapiens Q8WU90
Anti Tag CoIP
33961781
Intra
DRG1 Q9Y295 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
DRG1 Q9Y295 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
DRG1 Q9Y295 SSX2IP Homo sapiens Q9Y2D8
Y2H Array
25416956
Intra
DRG1 Q9Y295 SSX2IP Homo sapiens Q9Y2D8
Validated Y2H
25416956
Intra
DRG1 Q9Y295 SSX2IP Homo sapiens Q9Y2D8
Y2H Prey Pooling
25416956
Intra
DRG1 Q9Y295 SKIL Homo sapiens P12757
Y2H Array
25416956
Intra
DRG1 Q9Y295 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
Intra
DRG1 Q9Y295 PHC2 Homo sapiens Q8IXK0
Y2H Array
25416956
Intra
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Prey Pooling
32296183
Intra
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Array
25416956
Intra
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Array
32296183
Intra
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Pooling
16189514
Intra
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Pull Down
16189514
Intra
DRG1 Q9Y295 RWDD1 Homo sapiens Q9H446
Y2H Prey Pooling
25416956
Intra
DRG1 Q9Y295 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
DRG1 Q9Y295 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
DRG1 Q9Y295 STK16 Homo sapiens O75716
Y2H Prey Pooling
25416956
Intra
DRG1 Q9Y295 COIL Homo sapiens P38432
Validated Y2H
25416956
Intra
DRG1 Q9Y295 COIL Homo sapiens P38432
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, X-Linked Recessive, 5

CMTX5

Rosenberg-Chutorian Syndrome

Charcot-Marie-Tooth Disease X-Linked Recessive 5

Optic Atrophy, Polyneuropathy, And Deafness

Charcot-Marie-Tooth Neuropathy X-Linked Recessive 5

Cmt5x

X-Linked Charcot-Marie-Tooth Disease Type 5

Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 5

Optic Atrophy Polyneuropathy Deafness

Optic Atrophy With Polyneuropathy And Deafness

Charcot-Marie-Tooth Disease, X-Linked Recessive, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04009 DRG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DRG1 VGNC VGNC:84729
Felis catus DRG1 VGNC VGNC:61630
Canis familiaris DRG1 VGNC VGNC:40097
Rattus norvegicus DRG1 RGD RGD:1304993
Bos taurus DRG1 VGNC VGNC:53899
Mus musculus DRG1 MGD MGI:1343297
Others DRG1 NCBI