2. Gene
  3. DRG1 - developmentally regulated GTP binding protein 1 Gene

DRG1 - developmentally regulated GTP binding protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NEDD3

Gene ID: 4733 | Gene type: protein coding

About DRG1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,399,604-31,434,452 (from NCBI)

This gene has 7 transcripts (splice variants), 208 orthologues and 4 paralogues. Broad expression in testis (RPKM 112.9), thyroid (RPKM 23.8) and 24 other tissues.

Summary

Enables several functions, including GTPase activity; identical protein binding activity; and potassium ion binding activity. Involved in positive regulation of microtubule polymerization and regulation of mitotic spindle assembly. Located in cytosol and nuclear body. Part of polysome. [provided by Alliance of Genome Resources, Apr 2022]

DRG1 Products(1)

mRNA Protein Name
NM_004147.4 NP_004138.1 developmentally-regulated GTP-binding protein 1

DRG1 Protein Structure

MMR_HSR1

MMR_HSR1: 50S ribosome-binding GTPase (66 - 165)

TGS

TGS: TGS domain (292 - 366)

  • 0
  • 100
  • 200
  • 300
  • 367 a.a.
Protein Preferred Names Protein Names

developmentally-regulated GTP-binding protein 1

DRG-1

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, X-Linked Recessive, 5

CMTX5

Rosenberg-Chutorian Syndrome

Charcot-Marie-Tooth Disease X-Linked Recessive 5

Optic Atrophy, Polyneuropathy, And Deafness

Charcot-Marie-Tooth Neuropathy X-Linked Recessive 5

Cmt5x

X-Linked Charcot-Marie-Tooth Disease Type 5

Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 5

Optic Atrophy Polyneuropathy Deafness

Optic Atrophy With Polyneuropathy And Deafness

Charcot-Marie-Tooth Disease, X-Linked Recessive, Type 5
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04009 DRG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta DRG1 VGNC VGNC:84729
Felis catus DRG1 VGNC VGNC:61630
Canis familiaris DRG1 VGNC VGNC:40097
Rattus norvegicus DRG1 RGD RGD:1304993
Bos taurus DRG1 VGNC VGNC:53899
Mus musculus DRG1 MGD MGI:1343297
Others DRG1 NCBI