NEDD8 - NEDD8 ubiquitin like modifier Gene

Homo sapiens

Also known as NEDD-8

Gene ID: 4738 | Gene type: protein coding

About NEDD8

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,216,857-24,232,367 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 217 orthologues and 10 paralogues. Ubiquitous expression in fat (RPKM 81.8), kidney (RPKM 81.6) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Apr 2022]

NEDD8 Products(1)

mRNA	Protein	Name
NM_006156.3	NP_006147.1	NEDD8

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15988528	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	15694336	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within protein neddylation	IDA IDA: Inferred from direct assay	10500095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEDD8 Protein Structure

ubiquitin

0
81 a.a.

Protein Preferred Names

Protein Names

NEDD8

neddylin

NEDD8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NEDD8	Q15843	UBE2M	Homo sapiens	P61081	TAP	18274552
Intra	NEDD8	Q15843	UBE2M	Homo sapiens	P61081	Comigration in SDS	21765416
Intra	NEDD8	Q15843	UBE2M	Homo sapiens	P61081	TAP	21145461
Intra	NEDD8	Q15843	RPL7	Homo sapiens	P18124	Pull Down	18274552
Intra	NEDD8	Q15843	RPL7	Homo sapiens	P18124	TAP	18274552
Intra	NEDD8	Q15843	TUBB	Homo sapiens	P07437	TAP	21145461
Intra	NEDD8	Q15843	RPS3	Homo sapiens	P23396	TAP	18274552
Intra	NEDD8	Q15843	RPS3	Homo sapiens	P23396	TAP	21145461
Intra	NEDD8	Q15843	GSN	Homo sapiens	P06396	Y2H Array	32814053
Intra	NEDD8	Q15843	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	NEDD8	Q15843	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	NEDD8	Q15843	RPS20	Homo sapiens	P60866	TAP	21145461
Intra	NEDD8	Q15843	RPS20	Homo sapiens	P60866	TAP	18274552
Intra	NEDD8	Q15843	RPS7	Homo sapiens	P62081	TAP	18274552
Intra	NEDD8	Q15843	RPL11	Homo sapiens	P62913	Pull Down	18274552
Intra	NEDD8	Q15843	RPL11	Homo sapiens	P62913	TAP	18274552
Intra	NEDD8	Q15843	RPL11	Homo sapiens	P62913	TAP	21145461
Intra	NEDD8	Q15843	CUL1	Homo sapiens	Q13616	Anti Bait CoIP	17318178
Intra	NEDD8	Q15843	CUL1	Homo sapiens	Q13616	Comigration in SDS	18264111
Intra	NEDD8	Q15843	CUL1	Homo sapiens	Q13616	Anti Bait CoIP	21102408
Intra	NEDD8	Q15843	CUL1	Homo sapiens	Q13616	TAP	18274552
Intra	NEDD8	Q15843	CUL1	Homo sapiens	Q13616	Anti Bait CoIP	19713960
Intra	NEDD8	Q15843	CUL1	Homo sapiens	Q13616	TAP	21145461
Intra	NEDD8	Q15843	STON2	Homo sapiens	Q8WXE9	Anti Bait CoIP	21102408
Intra	NEDD8	Q15843	KHNYN	Homo sapiens	O15037	Pull Down	30659753
Intra	NEDD8	Q15843	KHNYN	Homo sapiens	O15037	Phage Display	30659753
Intra	NEDD8	Q15843	UCHL1	Homo sapiens	P09936	Y2H Pooling	16169070
Intra	NEDD8	Q15843	POLI	Homo sapiens	Q9UNA4	Pull Down	30659753
Intra	NEDD8	Q15843	POLI	Homo sapiens	Q9UNA4	Phage Display	30659753
Intra	NEDD8	Q15843	RAD23A	Homo sapiens	P54725	Pull Down	30659753
Intra	NEDD8	Q15843	RAD23A	Homo sapiens	P54725	Phage Display	30659753

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NEDD8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70843	NEDD8 Protein, Human	Q15843 (M1-G76)	≥95%

Related Diseases

Diseases

Alias

Malignant Astrocytoma

Astrocytic Tumor	Astrocytoma Of Brain
Astrocytoma Of Cerebrum	Astroglioma
Cerebral Astrocytoma	Astrocytoma

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-70062	Pevonedistat	Inhibitor	99.98%	Phase 3
HY-10484	Pevonedistat hydrochloride	Inhibitor	99.19%	Phase 3
HY-128586	TAS4464	Inhibitor	99.52%	Phase 1
HY-128586A	TAS4464 hydrochloride	Inhibitor	98.12%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108702	ML-792	Inhibitor	99.90%	Unkown
HY-101790A	ZM223 hydrochloride	Inhibitor	99.21%	Unkown
HY-115537	NAE-IN-M22	Activator	99.94%	Unkown
HY-101790	ZM223	Inhibitor	/	Unkown
HY-163105	Tubulin/NEDDylation-IN-1	Inhibitor	98.03%	Unkown
HY-159601	CSN5-IN-1	Inhibitor	/	Unkown
HY-RS09181	NEDD8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NEDD8	VGNC	VGNC:80899
Mus musculus	NEDD8	MGD	MGI:97301
Canis familiaris	NEDD8	VGNC	VGNC:56061
Rattus norvegicus	NEDD8	RGD	RGD:3158

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