NFKBIB - NFKB inhibitor beta Gene

Homo sapiens

Also known as IKBB; TRIP9

Gene ID: 4793 | Gene type: protein coding

About NFKBIB

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,899,666-38,908,889 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 125 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

NFKBIB Products(4)

mRNA	Protein	Name
NM_001243116.2	NP_001230045.1	NF-kappa-B inhibitor beta isoform 2
NM_001369699.1	NP_001356628.1	NF-kappa-B inhibitor beta isoform 3
NM_001369700.1	NP_001356629.1	NF-kappa-B inhibitor beta isoform 4
NM_002503.5	NP_002494.2	NF-kappa-B inhibitor beta isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10498867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBIB Protein Structure

Ank_2

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor beta

I-kappa-B-beta

Recombinant NFKBIB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76986	IKB beta/NFKBIB Protein, Human (His)	Q15653-1/NP_002494.2 (M1-V356)	≥95%

Related Diseases

Diseases

Alias

Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant

ECTD10A	Hed
Ectodermal Dysplasia 10a	Ectodermal Dysplasia Hypohidrotic Autosomal Dominant
Autosomal Dominant Hypohidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant
Hypohidrotic Ectodermal Dysplasia Autosomal Dominant	Ad-Hed
Autosomal Dominant Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia 3
Ed3	Eda3
Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant	Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant
Dysplasia, Ectodermal, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09261	NFKBIB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFKBIB	MGD	MGI:104752
Felis catus	NFKBIB	VGNC	VGNC:68484
Macaca mulatta	NFKBIB	VGNC	VGNC:75341
Bos taurus	NFKBIB	VGNC	VGNC:32046
Rattus norvegicus	NFKBIB	RGD	RGD:621887
Canis familiaris	NFKBIB	VGNC	VGNC:43783
Others	NFKBIB	NCBI

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