NFKBIB - NFKB inhibitor beta Gene

Homo sapiens

Also known as IKBB; TRIP9

Gene ID: 4793 | Gene type: protein coding

About NFKBIB

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,899,666-38,908,889 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 125 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 8.2), bone marrow (RPKM 7.5) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

NFKBIB Products(4)

mRNA	Protein	Name
NM_001243116.2	NP_001230045.1	NF-kappa-B inhibitor beta isoform 2
NM_001369699.1	NP_001356628.1	NF-kappa-B inhibitor beta isoform 3
NM_001369700.1	NP_001356629.1	NF-kappa-B inhibitor beta isoform 4
NM_002503.5	NP_002494.2	NF-kappa-B inhibitor beta isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10498867	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFKBIB Protein Structure

Ank_2

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

NF-kappa-B inhibitor beta

I-kappa-B-beta

NFKBIB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NFKBIB	Q15653	BTBD6	Homo sapiens	Q96KE9-2	Y2H Prey Pooling	32296183
Intra	NFKBIB	Q15653	BTBD6	Homo sapiens	Q96KE9-2	Validated Y2H	32296183
Intra	NFKBIB	Q15653	BTBD6	Homo sapiens	Q96KE9-2	Y2H Array	32296183
Intra	NFKBIB	Q15653	NDUFB7	Homo sapiens	P17568	Y2H Array	32296183
Intra	NFKBIB	Q15653	NDUFB7	Homo sapiens	P17568	Y2H Prey Pooling	32296183
Intra	NFKBIB	Q15653	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	25416956
Intra	NFKBIB	Q15653	NFKB1	Homo sapiens	P19838	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	NFKB2	Homo sapiens	Q00653	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	NFKB2	Homo sapiens	Q00653	TAP	14743216
Intra	NFKBIB	Q15653	REL	Homo sapiens	Q04864	TAP	14743216
Intra	NFKBIB	Q15653	REL	Homo sapiens	Q04864	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	NFKBIA	Homo sapiens	P25963	TAP	14743216
Intra	NFKBIB	Q15653	MCC	Homo sapiens	P23508	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	MCC	Homo sapiens	P23508	Anti Tag CoIP	14743216
Intra	NFKBIB	Q15653	RASAL2	Homo sapiens	Q9UJF2	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	POLR1E	Homo sapiens	Q9GZS1	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	NFKBIB	Q15653	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	NFKBIB	Q15653	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	NFKBIB	Q15653	RELA	Homo sapiens	Q04206	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	RELA	Homo sapiens	Q04206	Y2H	10498867
Intra	NFKBIB	Q15653	RELA	Homo sapiens	Q04206	Y2H Array	21988832
Intra	NFKBIB	Q15653	CHUK	Homo sapiens	O15111	TAP	14743216
Intra	NFKBIB	Q15653	CHUK	Homo sapiens	O15111	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	33961781
Intra	NFKBIB	Q15653	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	33961781
Cross	NFKBIB	Q15653	polg_den2n	Dengue virus type 2	P14340	Anti Tag CoIP	24973451

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NFKBIB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76986	IKB beta/NFKBIB Protein, Human (His)	Q15653-1/NP_002494.2 (M1-V356)	≥95%

Related Diseases

Diseases

Alias

Ectodermal Dysplasia 10a, Hypohidrotic/Hair/Nail Type, Autosomal Dominant

ECTD10A	Hed
Ectodermal Dysplasia 10a	Ectodermal Dysplasia Hypohidrotic Autosomal Dominant
Autosomal Dominant Hypohidrotic Ectodermal Dysplasia	Ectodermal Dysplasia, Hypohidrotic, Autosomal Dominant
Hypohidrotic Ectodermal Dysplasia Autosomal Dominant	Ad-Hed
Autosomal Dominant Anhidrotic Ectodermal Dysplasia	Ectodermal Dysplasia 3
Ed3	Eda3
Ectodermal Dysplasia, Anhidrotic, Autosomal Dominant	Dysplasia, Ectodermal, Type 10a, Hypohidrotic/Hair/Nail, Autosomal Dominant
Dysplasia, Ectodermal, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09261	NFKBIB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NFKBIB	MGD	MGI:104752
Felis catus	NFKBIB	VGNC	VGNC:68484
Macaca mulatta	NFKBIB	VGNC	VGNC:75341
Bos taurus	NFKBIB	VGNC	VGNC:32046
Rattus norvegicus	NFKBIB	RGD	RGD:621887
Canis familiaris	NFKBIB	VGNC	VGNC:43783
Others	NFKBIB	NCBI

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