HSD17B14 - hydroxysteroid 17-beta dehydrogenase 14 Gene

Homo sapiens

Also known as DHRS10; SDR47C1; retSDR3

Gene ID: 51171 | Gene type: protein coding

About HSD17B14

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,813,018-48,836,491 (from NCBI)

This gene has 4 transcripts (splice variants), 159 orthologues and 25 paralogues. Broad expression in kidney (RPKM 32.8), ovary (RPKM 12.9) and 14 other tissues.

Summary

17-beta-hydroxysteroid dehydrogenases, such as HSD17B14, are primarily involved in metabolism of Steroids at the C17 position and also of Other substrates, such as fatty acids, prostaglandins, and xenobiotics (Lukacik et al., 2007 [PubMed 17067289]).[supplied by OMIM, Jun 2009]

HSD17B14 Products(1)

mRNA	Protein	Name
NM_016246.3	NP_057330.2	17-beta-hydroxysteroid dehydrogenase 14

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables estradiol 17-beta-dehydrogenase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	17067289	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables testosterone 17-beta-dehydrogenase (NADP+) activity	IDA IDA: Inferred from direct assay	17067289	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in steroid catabolic process	IDA IDA: Inferred from direct assay	17067289	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	17067289	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSD17B14 Protein Structure

adh_short

0
100
200
270 a.a.

Protein Preferred Names

Protein Names

17-beta-hydroxysteroid dehydrogenase 14

17-beta-HSD 14

HSD17B14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HSD17B14	Q9BPX1	DDIT3	Homo sapiens	P35638-2	Validated Y2H	25416956
Intra	HSD17B14	Q9BPX1	tmp_locus_54	Homo sapiens	Q53NU3	Y2H Prey Pooling	25416956
Intra	HSD17B14	Q9BPX1	tmp_locus_54	Homo sapiens	Q53NU3	Y2H Array	25416956
Intra	HSD17B14	Q9BPX1	MGC4677	Homo sapiens	Q53S70	Validated Y2H	25416956
Intra	HSD17B14	Q9BPX1	SNRPC	Homo sapiens	Q5TAL4	Validated Y2H	25416956
Intra	HSD17B14	Q9BPX1	SNRPC	Homo sapiens	Q5TAL4	Y2H Array	25416956
Intra	HSD17B14	Q9BPX1	SREK1IP1	Homo sapiens	Q8N9Q2	Validated Y2H	25416956
Intra	HSD17B14	Q9BPX1	SREK1IP1	Homo sapiens	Q8N9Q2	Y2H Prey Pooling	25416956
Intra	HSD17B14	Q9BPX1	SREK1IP1	Homo sapiens	Q8N9Q2	Y2H Array	25416956
Intra	HSD17B14	Q9BPX1	MPG	Homo sapiens	P29372	Y2H Array	25416956
Intra	HSD17B14	Q9BPX1	MPG	Homo sapiens	P29372	Y2H Array	31515488
Intra	HSD17B14	Q9BPX1	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	HSD17B14	Q9BPX1	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	HSD17B14	Q9BPX1	NEK6	Homo sapiens	Q9HC98-4	Validated Y2H	32296183
Intra	HSD17B14	Q9BPX1	PIDD1	Homo sapiens	Q9HB75-2	Validated Y2H	32296183
Intra	HSD17B14	Q9BPX1	OTUD3	Homo sapiens	Q5T2D3	Y2H Array	32296183
Intra	HSD17B14	Q9BPX1	OTUD3	Homo sapiens	Q5T2D3	Y2H Prey Pooling	32296183
Intra	HSD17B14	Q9BPX1	SNAPC3	Homo sapiens	Q92966	Validated Y2H	25416956
Intra	HSD17B14	Q9BPX1	SNAPC3	Homo sapiens	Q92966	Y2H Prey Pooling	25416956
Intra	HSD17B14	Q9BPX1	BRIP1	Homo sapiens	Q9BX63	Anti Tag CoIP	33961781
Intra	HSD17B14	Q9BPX1	BRIP1	Homo sapiens	Q9BX63	Validated Y2H	32296183
Intra	HSD17B14	Q9BPX1	PHF1	Homo sapiens	O43189	Y2H Array	31515488
Intra	HSD17B14	Q9BPX1	PHF1	Homo sapiens	O43189	Y2H Prey Pooling	25416956
Intra	HSD17B14	Q9BPX1	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	HSD17B14	Q9BPX1	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	HSD17B14	Q9BPX1	CA8	Homo sapiens	P35219	Y2H Prey Pooling	25416956
Intra	HSD17B14	Q9BPX1	CA8	Homo sapiens	P35219	Y2H Array	25416956
Intra	HSD17B14	Q9BPX1	CA8	Homo sapiens	P35219	Validated Y2H	27107012
Intra	HSD17B14	Q9BPX1	NEK6	Homo sapiens	Q9HC98	Validated Y2H	25416956
Intra	HSD17B14	Q9BPX1	NUDT18	Homo sapiens	Q6ZVK8	Y2H Pooling	16189514
Intra	HSD17B14	Q9BPX1	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	27107012
Intra	HSD17B14	Q9BPX1	NTAQ1	Homo sapiens	Q96HA8	Y2H Pooling	19060904
Intra	HSD17B14	Q9BPX1	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	19060904
Intra	HSD17B14	Q9BPX1	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	HSD17B14	Q9BPX1	NTAQ1	Homo sapiens	Q96HA8	Y2H Pooling	16189514
Intra	HSD17B14	Q9BPX1	DDIT3	Homo sapiens	P35638	BFG-2H	27107012
Intra	HSD17B14	Q9BPX1	DDIT3	Homo sapiens	P35638	Y2H Array	32296183
Intra	HSD17B14	Q9BPX1	DDIT3	Homo sapiens	P35638	Y2H Prey Pooling	32296183
Intra	HSD17B14	Q9BPX1	CDKN2D	Homo sapiens	P55273	Validated Y2H	25416956
Intra	HSD17B14	Q9BPX1	CDKN2D	Homo sapiens	P55273	Y2H Array	25416956
Intra	HSD17B14	Q9BPX1	CDKN2D	Homo sapiens	P55273	Y2H Prey Pooling	25416956
Intra	HSD17B14	Q9BPX1	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	HSD17B14	Q9BPX1	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	29892012
Intra	HSD17B14	Q9BPX1	TBC1D22B	Homo sapiens	Q9NU19	Validated Y2H	32296183
Intra	HSD17B14	Q9BPX1	TBC1D22B	Homo sapiens	Q9NU19	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HSD17B14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76975	HSD17B14 Protein, Human (HEK293, His)	Q9BPX1/NP_057330.2 (M1-S270)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06394	HSD17B14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HSD17B14	RGD	RGD:1588673
Mus musculus	HSD17B14	MGD	MGI:1913315
Bos taurus	HSD17B14	VGNC	VGNC:29972
Felis catus	HSD17B14	VGNC	VGNC:97458
Canis familiaris	HSD17B14	VGNC	VGNC:41804
Others	HSD17B14	NCBI

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