TRAPPC2L - trafficking protein particle complex subunit 2L Gene

Homo sapiens

Also known as PERRB; HSPC176

Gene ID: 51693 | Gene type: protein coding

About TRAPPC2L

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,856,220-88,862,678 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 16.3), testis (RPKM 13.9) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

TRAPPC2L Products(9)

mRNA	Protein	Name
NM_001318524.2	NP_001305453.1	trafficking protein particle complex subunit 2-like protein isoform 1
NM_001318525.2	NP_001305454.1	trafficking protein particle complex subunit 2-like protein isoform 3
NM_001318526.2	NP_001305455.1	trafficking protein particle complex subunit 2-like protein isoform 4
NM_001318527.2	NP_001305456.1	trafficking protein particle complex subunit 2-like protein isoform 5
NM_001318528.2	NP_001305457.1	trafficking protein particle complex subunit 2-like protein isoform 6
NM_001318529.2	NP_001305458.1	trafficking protein particle complex subunit 2-like protein isoform 7
NM_001318530.2	NP_001305459.1	trafficking protein particle complex subunit 2-like protein isoform 8
NM_001318532.2	NP_001305461.1	trafficking protein particle complex subunit 2-like protein isoform 9
NM_016209.5	NP_057293.1	trafficking protein particle complex subunit 2-like protein isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of TRAPP complex	IDA IDA: Inferred from direct assay	21525244	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAPPC2L Protein Structure

Sedlin_N

0
100
140 a.a.

Protein Preferred Names

Protein Names

trafficking protein particle complex subunit 2-like protein

hematopoietic stem/progenitor cells 176

TRAPPC2L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRAPPC2L	Q9UL33	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
Intra	TRAPPC2L	Q9UL33	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
Intra	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-2	Y2H Array	25416956
Intra	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-2	Y2H Prey Pooling	25416956
Intra	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-3	Y2H Prey Pooling	25416956
Intra	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-3	Validated Y2H	25416956
Intra	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-3	Y2H Array	25416956
Intra	TRAPPC2L	Q9UL33	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	25416956
Intra	TRAPPC2L	Q9UL33	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	25416956
Intra	TRAPPC2L	Q9UL33	TRAPPC8	Homo sapiens	Q9Y2L5	Anti Tag CoIP	33961781
Intra	TRAPPC2L	Q9UL33	TRAPPC8	Homo sapiens	Q9Y2L5	Anti Tag CoIP	21453443
Intra	TRAPPC2L	Q9UL33	TRAPPC13	Homo sapiens	A5PLN9	Anti Tag CoIP	21453443
Intra	TRAPPC2L	Q9UL33	TRAPPC13	Homo sapiens	A5PLN9	Anti Tag CoIP	33961781
Intra	TRAPPC2L	Q9UL33	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	TRAPPC2L	Q9UL33	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	TRAPPC2L	Q9UL33	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	TRAPPC2L	Q9UL33	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	TRAPPC2L	Q9UL33	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	25416956
Intra	TRAPPC2L	Q9UL33	TRIP6	Homo sapiens	Q15654	Validated Y2H	25416956
Intra	TRAPPC2L	Q9UL33	TRIP6	Homo sapiens	Q15654	Y2H Array	25416956
Intra	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Y2H	21827752
Intra	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Anti Tag CoIP	21453443
Intra	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Validated Y2H	25416956
Intra	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Anti Tag CoIP	33961781
Intra	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Encephalopathy, Progressive, Early-Onset, With Episodic Rhabdomyolysis

PEERB

Mucopolysaccharidosis, Type Iva

Mps Iva	Galns Deficiency
MPS4A	Morquio A Disease
Galactosamine-6-Sulfatase Deficiency	Morquio Syndrome A
Mucopolysaccharidosis Iva	Mucopolysaccharidosis Type Iva
Mpsiva	Morquio Disease Type A
Mucopolysaccharidosis Type 4a	N-Acetylgalactosamine-6-Sulfate Sulfatase Deficiency
Morquio Syndrome Type A	Mps 4a
Morquio Disease, Type A	Mucopolysaccharidosis 4a
Morquio'S Syndrome A	Mps Iv A
Mucopolysaccharidosis Iv	Mucopolysaccharidosis, Mps-Iv-A

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies	Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies
Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome	Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda	X-Linked Spondyloepiphyseal Dysplasia Tarda
SEDT	Sed Tarda, X-Linked
Spondyloepiphyseal Dysplasia, Late	Spondyloepiphyseal Dysplasia Tarda X-Linked
Sed	X Linked Spondyloepiphyseal Dysplasia Tarda
X-Linked Spondyloepiphyseal Dysplasia	Late Onset Spondyloepiphyseal Dysplasia
Sed Tarda	X-Linked Sed
X-Linked Sedt	Dysplasia, Spondyloepiphyseal, Tarda
Spondyloepiphyseal Dysplasia

Neu-Laxova Syndrome 2

NLS2

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14989	TRAPPC2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRAPPC2L	RGD	RGD:1304906
Bos taurus	TRAPPC2L	VGNC	VGNC:36287
Mus musculus	TRAPPC2L	MGD	MGI:1916295
Canis familiaris	TRAPPC2L	VGNC	VGNC:47780

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