1. Gene
  2. PIP - prolactin induced protein Gene

PIP - prolactin induced protein Gene

Homo sapiens

Also known as GPIP4; BRST-2; GCDFP15; GCDFP-15

Gene ID: 5304 | Gene type: protein coding

About PIP

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,132,077-143,139,739 (from NCBI)

This gene has 1 transcript (splice variant) and 76 orthologues. Restricted expression toward salivary gland (RPKM 2757.7).

Summary

Enables IgG binding activity; aspartic-type endopeptidase activity; and identical protein binding activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of bitter taste; negative regulation of T cell apoptotic process; and proteolysis. Located in extracellular space and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PIP Products(1)

mRNA Protein Name
NM_002652.3 NP_002643.1 prolactin-inducible protein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables IgG binding IDA
IDA: Inferred from direct assay
14638438 GOA
enables aspartic-type endopeptidase activity IMP
IMP: Inferred from mutant phenotype
10713110 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
10713110 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18930737 GOA
Biological Process GO Annotation Evidence Reference Source
involved in detection of chemical stimulus involved in sensory perception of bitter taste IDA
IDA: Inferred from direct assay
24248522 GOA
involved in negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
10072505 GOA
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
10072505 GOA
involved in proteolysis IMP
IMP: Inferred from mutant phenotype
10713110 GOA
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
10713110 GOA
located in nucleus IDA
IDA: Inferred from direct assay
22720776 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIP Protein Structure

SVA

SVA: Seminal vesicle autoantigen (SVA) (4 - 126)

  • 0
  • 100
  • 146 a.a.
Protein Preferred Names Protein Names

prolactin-inducible protein

SABP

Recombinant PIP Proteins

Cat. No. Product Name Accession Purity
HY-P78015 PIP/GCDFP-15 Protein, Human (His) P12273 (Q29-E146) ≥95%

Related Diseases

Diseases Alias
Breast Cyst

Cyst Of The Breast

Breast Cysts

Sweat Gland Cancer

Sweat Gland Carcinoma

Malignant Neoplasm Of Sweat Gland

Malignant Tumor Of The Sweat Gland

Carcinoma Of The Sweat Gland

Primary Malignant Neoplasm Of Sweat Gland

Sweat Gland Neoplasms

Microglandular Adenosis

Breast Fibrocystic Disease

Adenosis - Breast

Adenosis Of The Breast

Fibrocystic Breast Disease

Breast Adenosis

Adenosis Of Breast

Paget Disease, Extramammary

Extramammary Paget Disease

Cutaneous Paget'S Disease

Extramammary Paget'S Disease

Paget Disease Extramammary

Cutaneous Paget Disease

Paget'S Disease Of Skin

Empd

Extramammary Pagets Disease

Breast Ductal Carcinoma

Ductal Breast Carcinoma

Duct Carcinoma

Carcinoma, Ductal

Mammary Ductal Carcinoma

Ductal Carcinoma

Apocrine Adenocarcinoma

Apocrine Carcinoma

Apocrine Gland Carcinoma

Carcinoma Of The Apocrine Gland

Carcinoma Of Apocrine Gland

Sweat Gland Disease

Sweat Gland Diseases

Sweat Gland Benign Neoplasm

Neoplasm Of Sweat Gland

Sweat Gland Tumor

Tumor Of The Sweat Gland

Sweat Gland Neoplasms

Sweat Gland Neoplasm

Blepharitis
Signet Ring Cell Adenocarcinoma

Signet Ring Cell Carcinoma

Carcinoma, Signet Ring Cell

Signet Ring Carcinoma

Carcinoma Signet Ring Cell

Anal Canal Carcinoma

Anal Canal Cancer

Anal Canal And Perianal Gland Carcinoma

Carcinoma Of The Anal Canal

Carcinoma Of Anal Canal

Breast Signet Ring Cell Adenocarcinoma

Mammary Signet Ring Cell Carcinoma

Signet Ring Cell Carcinoma Of Breast

Signet Ring Cell Breast Carcinoma

Apocrine Adenoma

Tubular Apocrine Adenoma

Gastric Diffuse Adenocarcinoma

Diffuse Gastric Adenocarcinoma

Carcinoma, Diffuse Type

Papillary Hidradenoma

Tubular Sweat Gland Adenomas

Lipid-Rich Carcinoma
Breast Apocrine Carcinoma

Apocrine Carcinoma Of Breast

Apocrine Breast Carcinoma

Anal Canal Paget'S Disease

Anal Canal Paget Disease

Paget'S Disease Of Anal Canal

Paget'S Disease Of The Anal Canal

Paget Disease Of The Anal Canal

Breast Papillary Carcinoma

Breast Solid Papillary Carcinoma

Papillary Carcinoma Of Breast

Papillary Carcinoma Of The Breast

Solid Papillary Carcinoma Of The Breast

Peritoneal Serous Papillary Adenocarcinoma

Primary Serous Papillary Carcinoma Of Peritoneum

Nipples, Supernumerary

Supernumerary Nipple

Accessory Nipples

Polymastia

Polythelia, Familial

Familial Supernumerary Nipples

Isolated Polythelia

Ectopic Nipple

Extra Nipple

Hyperthelia

Polythelia

Oncocytic Breast Carcinoma
Eccrine Papillary Adenoma

Papillary Eccrine Adenoma

Eccrine Papillary Adenoma Of Skin

Breast Mucinous Carcinoma

Mucinous Carcinoma Of Breast

Invasive Mucinous Breast Carcinoma

Apocrine Sweat Gland Neoplasm

Apocrine Tumor

Apocrine Neoplasm

Vulvar Apocrine Adenocarcinoma
Bartholin'S Gland Adenocarcinoma

Bartholin Gland Adenocarcinoma

Adenocarcinoma Of Bartholin'S Gland

Adenocarcinoma Of The Bartholin'S Gland

Syringocystadenoma Papilliferum

Fistulous Vegetative Verrucous Hydradenoma

Papillary Syringadenoma

Naevus Syringocystadenomatosus Papilliferus

Papillary Syringocystadenoma

Scap

Syringadenoma Papilliferum

Papillary Hidradenoma

Papillary Adenocarcinoma

Infiltrating And Papillary Adenocarcinoma

Infiltrating Papillary Adenocarcinoma

Adenocarcinoma Papillary

Adenocarcinoma, Papillary

Borst-Jadassohn Intraepidermal Carcinoma

Intraepidermal Epithelioma Of Jadassohn

Bowen'S Disease, Clonal

Vulval Paget'S Disease

Paget'S Disease Of Vulva

Vulval Paget Disease

Vulvar Paget'S Disease

Extramammary Paget Disease Of Vulva

Vulva Adenocarcinoma

Adenocarcinoma Of The Vulva

Adenocarcinoma Of Vulva

Vulvar Eccrine Porocarcinoma
Sebaceous Breast Carcinoma
Eyelid Carcinoma

Carcinoma Of The Eyelid

Sebaceous Adenocarcinoma

Sebaceous Carcinoma

Adenocarcinoma Of The Sebaceous Gland

Malignant Neoplasm Of Sebaceous Gland

Malignant Sebaceous Tumor

Adenocarcinoma, Sebaceous

Malignant Sebaceous Neoplasm

Sebaceous Gland Neoplasms

Nodular Hidradenoma

Eccrine Nodular Hidradenoma

Eccrine Acrospiroma

Erythrasma

Infection Due To Corynebacterium Minutissimum

Anus Adenocarcinoma

Adenocarcinoma Of Anus

Adenocarcinoma Of The Anus

Gastric Signet Ring Cell Adenocarcinoma

Signet Ring Cell Gastric Adenocarcinoma

Signet Ring Cell Adenocarcinoma Of The Stomach

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Clear Cell Hidradenoma

Clear Cell Myoepithelioma

Eccrine Acrospiroma

Eccrine Adenocarcinoma
Lacrimal Gland Carcinoma

Lacrimal Gland Cancer

Carcinoma Of The Lacrimal Gland

Malignant Neoplasm Of Lacrimal Gland

Malignant Tumour Of Lacrimal Gland

Neoplasm Of Lacrimal Gland

Tumor Of The Lacrimal Gland

Malignant Tumor Of Lacrimal Gland

Hidrocystoma

Apocrine Cystadenoma

Eccrine Hidrocystoma

Eccrine Cystadenoma

Eccrine Hidrocystoma Of Skin

Apocrine Adenoma

Hidradenoma

Adenoma, Sweat Gland

Hidradenoma Of Skin

Sweat Gland Adenoma

Syringoadenoma

Eccrine Acrospiroma

Benign Neoplasm Of Sweat Gland

Glycogen-Rich Carcinoma

Doid:0081028

Cystic Basal Cell Carcinoma

Skin Cystic Basal Cell Carcinoma

Anal Canal Adenocarcinoma

Adenocarcinoma Of The Anal Canal

Adenocarcinoma Of Anal Canal

Breast Lobular Carcinoma

Cancer, Breast, Lobular

Lobular Breast Carcinoma

Fox-Fordyce Disease

Fox Fordyce Disease

Apocrine Miliaria

Fox-Fordyce Syndrome

Miliaria, Apocrine

Anal Gland Adenocarcinoma

Adenocarcinoma Of Anal Ducts

Adenocarcinoma Of Anal Gland

Anal Glands Adenocarcinoma

Adenocarcinoma Of Anal Glands

Linitis Plastica

Leather-Bottle Stomach

Female Breast Cancer

Female Breast Carcinoma

Carcinoma Of Female Breast

Mammary Carcinoma Of Female Breast

Malignant Neoplasm Of Female Breast

Malignant Syringoma

Microcystic Adnexal Carcinoma

Microcystic Adnexal Carcinoma Of Skin

Syringomatous Carcinoma

Eccrine Epithelioma

Malignant Acrospiroma

Eccrine Ductal Carcinoma

Hidradenocarcinoma

Anaplastic Syringoma

Eccrine Ductal Carcinoma Of Skin

Clear Cell Eccrine Carcinoma

Malignant Clear Cell Acrospiroma

Malignant Nodular/Clear Cell Hidradenoma

Primary Mucoepidermoid Cutaneous Carcinoma

Sweat Gland Adenocarcinoma

Malignant Spiradenoma

Malignant Eccrine Spiradenoma

Eccrine Spiradenoma, Malignant

Mes

Breast Secretory Carcinoma

Secretory Breast Carcinoma

Juvenile Breast Carcinoma

Juvenile Carcinoma Of The Breast

Juvenile Secretory Carcinoma Of Breast

Juvenile Breast Cancer

Sbc

Secretory Carcinoma Of The Breast

Vulva Cancer

Vulvar Carcinoma

Malignant Neoplasm Of Vulva

Vulva Carcinoma

Carcinoma Of Vulva

Vulvar Cancer

Vulval Cancer

Vulvar Neoplasms

Ca Vulva

Malignant Tumor Of Vulva

Malignant Vulvar Tumor

Neoplasm Of Vulva

Vulval Neoplasm

Vulvar Neoplasm

Vulvar Tumor

Cancer Of Vulva

Malignant Tumour Of Vulva

Salivary Gland Carcinoma

Salivary Gland Cancer

Malignant Neoplasm Of Salivary Gland

Salivary Gland Neoplasms

Peritoneal Serous Adenocarcinoma

Primary Peritoneal Serous Adenocarcinoma

Bartholin'S Duct Cyst

Bartholin Duct Cyst

Bartholin'S Cyst

Cyst Of Bartholin'S Gland Duct

Cyst Of Bartholin'S Gland

Vulvovaginal Cyst

Cyst Of Bartholin Gland Duct

Mixed Lacrimal Gland Cancer

Carcinoma Ex Pleomorphic Adenoma Of Lacrimal Gland

Carcinoma Ex Pleomorphic Adenoma Of The Lacrimal Gland

Malignant Mixed Neoplasm Of Lacrimal Gland

Erysipeloid

Infection Due To Erysipelothrix Rhusiopathiae

Erysipelothrix Infection

Cutaneous Mucoepidermoid Carcinoma

Mucoepidermoid Carcinoma Of Skin

Mucoepidermoid Skin Carcinoma

Eccrine Sweat Gland Cancer

Malignant Eccrine Skin Neoplasm

Malignant Eccrine Tumor

Spiradenoma

Eccrine Spiradenoma

Benign Eccrine Spiradenoma

Eccrine Spiradenoma Of Skin

Es

Eccrine Spiradenoma, Benign

Eccrine Sweat Gland Neoplasm

Eccrine Skin Neoplasm

Eccrine Tumor

Eccrine Neoplasm

Malignant Eccrine Neoplasm

Breast Neuroendocrine Neoplasm

Neuroendocrine Tumor Of The Breast

Papillary Cystadenocarcinoma

Cystadenocarcinoma, Papillary

Meibomian Cyst

Chalazion

Meibomian Gland Lipogranuloma

Tarsal Cyst

Breast Benign Neoplasm

Benign Tumour Of Breast

Benign Neoplasm Of Female Breast

Ceruminoma

Ceruminous Adenoma

External Auditory Canal Ceruminous Adenoma

Cribriform Carcinoma

Ductal Carcinoma, Cribriform Type

Carcinoma Cribriform

Carcinoma, Cribriform

Thoracic Benign Neoplasm

Benign Neoplasm Of Thorax

Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea

Bartholin'S Gland Disease

Bartholin Gland Disease

Syringoma

Syringomas

Mammary Paget'S Disease

Paget'S Disease

Mammary Paget Disease

Paget'S Disease Of The Breast

Paget Disease Of The Breast

Paget'S Disease Of The Nipple

Paget'S Disease, Mammary

Paget Cell Neoplasm

Paget Disease Of The Nipple

Pagets Disease Mammary

Osteitis Deformans

Mammary Analogue Secretory Carcinoma
Lacrimal System Cancer

Neoplasm Of Lacrimal System

Lacrimal System Neoplasm

Tumor Of The Lacrimal System

Anal Paget'S Disease

Anal Paget Disease

Paget'S Disease Of Anus

Paget'S Disease Of The Anus

Paget Disease Of The Anus

Lobular Neoplasia

Lobular Carcinoma In Situ

Lobular Carcinoma In Situ Of Breast

Lobular Intraepithelial Neoplasia

Non-Infiltrating Lobular Carcinoma

Noninfiltrating Lobular Carcinoma Unspecified Site

Noninfiltrating Lobular Carcinoma Of Breast

Lobular Carcinoma In Situ Unspecified Site

Eccrine Papillary Adenocarcinoma

Digital Papillary Adenocarcinoma

Sweat Gland Adenocarcinoma

Digital Papillary Eccrine Carcinoma Of Skin

Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma

Adenomyo-Epithelioma

Clear Cell Carcinoma

Emc

Epithelial Myoepithelial Carcinoma

Glycogen-Rich Adenocarcinoma

Glycogen-Rich Adenoma

Monomorphic Clear Cell Tumor

Tubular Solid Adenoma

Adenocarcinoma, Clear Cell

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Eccrine Porocarcinoma

Porocarcinoma

Eccrine Porocarcinoma Of Skin

Malignant Eccrine Poroma

Subungual Glomus Tumor

Subungual Glomus Tumour

Ceruminous Adenocarcinoma
Vulvar Syringoma
Vulvar Disease

Vulvar Diseases

Vulvar Disorders

Eccrine Acrospiroma

Acrospiroma

Poroma

Eccrine Hidradenoma

Eccrine Hidradenoma Of Skin

Hidradenoma

Adenoma, Sweat Gland

Benign Neoplasm Of Sweat Gland

Eccrine Poroma

Skin Benign Neoplasm

Neoplasm Of Skin By Site

Tumor Of The Skin

Skin Tumor

Benign Neoplasm Of Skin

Skin Neoplasms

Salivary Gland Adenoid Cystic Carcinoma

Cylindroma

Breast Carcinoma In Situ

Carcinoma In Situ Of Breast

Non-Infiltrating Carcinoma Of Breast

Breast Cancer In Situ

Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos

In Situ Carcinoma

Carcinoma In Situ

Ductal Carcinoma In Situ

Noninfiltrating Intraductal Carcinoma

Eyelid Disease

Eyelid Diseases

Eyelid Disorders

Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome

Pre-Malignant Neoplasm
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site

Hobnail Hemangioma
Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Bos taurus PIP VGNC VGNC:107231
Felis catus PIP VGNC VGNC:102662
Rattus norvegicus PIP RGD RGD:70946
Macaca mulatta PIP VGNC VGNC:81740
Canis familiaris PIP VGNC VGNC:44570
Mus musculus PIP MGD MGI:102696
Others PIP NCBI