2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc

(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

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(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc Chemical Structure

(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc Chemical Structure

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(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc is a conjugate of E3 ligase ligand and linker, consisting of (S,R,S)-AHPC (HY-125845) and the corresponding Linker. (S,R,S)-AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. (S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc can be used as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

von Hippel-Lindau (VHL)[1]
Molecular Weight

726.93

Formula

C37H54N6O7S
SMILES

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(CN2CCC(CC2)OC3CN(C3)C(OC(C)(C)C)=O)=O)=O)NCC(C=C4)=CC=C4C(SC=N5)=C5C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S,R,S)-AHPC-acetyl-Pip-O-azetidine-boc Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S,R,S)-AHPC-acetyl-Pip-O-azetidine-bocE3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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