Tpo - thyroid peroxidase Gene

Rattus norvegicus

Gene ID: 54314 | Gene type: protein coding

About Tpo

Summary

Predicted to enable iodide peroxidase activity. Involved in cellular response to nitric oxide and response to lipid. Located in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase). [provided by Alliance of Genome Resources, Apr 2022]

Tpo Products(1)

mRNA	Protein	Name
NM_019353.2	NP_062226.2	thyroid peroxidase precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to nitric oxide	IEP IEP: Inferred from expression pattern	17714035	RGD
involved in response to lipid	IEP IEP: Inferred from expression pattern	12748414	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15917231	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

thyroid peroxidase

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19883	Lusutrombopag	Agonist	98.88%	Unkown
HY-13463	Avatrombopag	Agonist	99.83%	Yes
HY-W017113	2-Mercaptobenzothiazole	Activator	99.85%	Yes
HY-13463B	Avatrombopag hydrochloride	Agonist	96.69%	Yes
HY-13463A	Avatrombopag maleate	Agonist	99.88%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145589	Rafutrombopag	Agonist	/	Phase 1

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990685	Romiplostim		≥99.0%	Phase 4

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148748	Butyzamide	Activator	99.62%	Unkown
HY-112486	TA-316		99.50%	Unkown
HY-W017894	TPO-L		99.40%	Unkown
HY-100380	TPO agonist 1	Agonist	≥98.0%	Unkown
HY-112486G	TA-316 (GMP)	Agonist	/	Unkown
HY-139915	MPO-IN-1	Inhibitor	99.02%	Unkown
HY-15306S	Eltrombopag-13C4		97.89%	Unkown
HY-19883S	Lusutrombopag-d13	Agonist	98.64%	Unkown
HY-13463BS	Avatrombopag-d8 hydrochloride	Agonist	/	Unkown
HY-147691	MPO-IN-5	Inhibitor	/	Unkown
HY-153239	Eltrombopag methyl ester	Agonist	/	Unkown
HY-RS14941	TPO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tpo	NCBI	NCBI:7173
Macaca fascicularis	Tpo	NCBI	NCBI:102125126
Mus musculus	Tpo	NCBI	NCBI:22018

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